A Path Forward to Save American Bio-Medical Research Over the past four months, I’ve spoken to dozens of biomedical researchers...

A Path Forward to Save American Bio-Medical Research talkingpointsmemo.com/edblog/a-pat...

Go crimson

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...

Wow

A cryptic pocket in CB1 drives peripheral and functional selectivity Nature - A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance,...

Excellent use of peripherally restricted targeting for analgesia and limiting unwanted central effects. rdcu.be/efdWs

NIH indirects case update:

Hearing ongoing now, and I'll try to live tweet some notable exchanges.

Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:

(I'm paraphrasing here)

“rescheduled” with no dates

Oh damn NPI just got rescheduled

Acetone–Ether–Water Mouse Model of Persistent Itch Fully Resolves Without Latent Pruritic or Cross-Modality Priming Hyperalgesic priming is a model of the transition from acute to chronic pain. Whether a similar mechanism exists for “pruritic priming” of itch is unknown. Here, we tested the hypothesis that itchy sk...

Don’t bother trying to find latent pruritic priming after dry skin; mc903, imiquimod…what’re you hiding?

We’re getting the rig fired up!

State attorneys general and University council activate!

Yes seems so, on schedule

(1/3) Dr. Kara Margolis, director of the @nyupainresearch.bsky.social
and associate professor of molecular pathobiology, co-authored two important studies published this week – one in Gastroenterology and one in Molecular Psychiatry – showing the connection between serotonin in the gut,

(2/3) mood disorders, and digestive issues. The studies show that increasing serotonin in the lining of the gut improves anxiety and depression, and that antidepressants during pregnancy increase the risk for digestive issues in children.

Scientists Find Promising New Target for Antidepressants—In the Gut Increasing serotonin in the lining of the gut improves anxiety and depression in animal studies and may offer new therapeutic approach during pregnancy to avoid newfound risk of digestive issues in ch...

(3/3)Together, the studies reveal a promising avenue for future research: targeting antidepressants selectively to the gut as a new and potentially safer way to treat mood disorders.
Read more about both studies: nyu.edu/about/news-p... & nature.com/articles/s41... #DGBI #BrainGut