Mar Albà lab (@maralbalab) Bsky

🚀Descobreix #HMRIB: El teu postdoc comença aquí!

🔬Línes de recerca, finançament (MSCA, EMBO) i desenvolupament de carrera professional.
👩‍🔬Coneix PIs i projectes.

📅15/04 |🕒10h
🖥️Online

📝Inscripcions i programa: researchmar.net/agenda/view....

@researchmar.bsky.social @hospitaldelmar.bsky.social

1 week ago 0 2 0 0

MicroRNA evolution and the genetic basis of placental phenotypic diversity across mammals at The University of Manchester on FindAPhD.com PhD Project - MicroRNA evolution and the genetic basis of placental phenotypic diversity across mammals at The University of Manchester, listed on FindAPhD.com

We are recruiting ! ... the second PhD position available with us at University of Manchester: www.findaphd.com/phds/project...

1 month ago 4 5 0 1

Defining the landscape of stop codon readthrough across vertebrate genomes at The University of Manchester on FindAPhD.com PhD Project - Defining the landscape of stop codon readthrough across vertebrate genomes at The University of Manchester, listed on FindAPhD.com

Come join us for a PhD at the University of Manchester :

1 month ago 4 5 0 1

Second preprint of the month!

Analysis of stop-loss mutations in > 20,000 cancer samples shows that several oncogenes and tumor suppressor genes are recurrently mutated. Another fruitful collaboration with @forteslab.bsky.social @grib-barcelona.bsky.social

www.biorxiv.org/content/10.6...

1 month ago 7 3 0 1

Evolutionary emergence and preservation of microproteins encoded by upstream ORFs The analysis of ribosome profiling (Ribo-Seq) data has provided evidence that many eukaryotic mRNAs contain translated upstream or downstream ORFs (uORFs/dORFs), but the biological significance of this translation activity remains, for the most part, unknown. One of the principal limitations has been the lack of Ribo-Seq data from several closely related species, precluding the identification of cases in which translation is phylogenetically conserved. Here, by combining Ribo-Seq data from 100 different experiments, we identify 2,332 translated uORFs and 1,008 translated dORFs in S. cerevisiae, which result in microproteins that tend to be highly hydrophobic or positively charged. To study their phylogenetic conservation, we have generated Nanopore direct RNA sequencing data, together with Ribo-Seq data, from six additional Saccharomyces species, spanning an evolutionary period of around 16 million years. We have identified 195 translated S. cerevisiae uORFs that are also translated in other Saccharomyces species; these uORFs are translated at levels comparable to the main coding sequence and display signatures of purifying selection at the level of the encoded microproteins. In contrast, dORFs are translated at very low levels and they are rarely conserved, suggesting much more limited microprotein functionalization. We have also discovered that uORF translation is associated with the formation of alternative transcript isoforms encompassing the region containing the uORFs but not the main protein coding sequence, implying that some microproteins can be produced independently of the main protein product. This work significantly advances our understanding of how initially pervasive uORF translation can result in new microproteins, providing many new candidates for further functional studies. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 101052538 Ministerio de Ciencia, Innovación y Universidades, PID2021- 122726NBI00, PGC2018-094091- B-I00, PID2022-136939OBI00, CEX2024-001431-M, MICIU/AEI/10.13039/501100011033 Generalitat de Catalunya, https://ror.org/01bg62x04, 2021SGR00042, 2021SGR00176

New preprint from the group!

Here we use Nanopore dRNA and Ribo-Seq data from multiple yeast species to discover tens of highly conserved microproteins encoded by uORFs in polycistronic transcripts/alternative isoforms. @prbb.org @grib-barcelona.bsky.social

www.biorxiv.org/content/10.6...

1 month ago 10 5 0 0

De novo genes arise from previously non-coding sequences. This evolutionary path — when randomly expressed sequences become folded and active proteins — challenges our understanding of genetic innovation. New Review by @bornberglab.bsky.social and @lacholt.bsky.social out now!

2 months ago 15 6 0 0

📢 EvoMG-DN PhD applications are now open!
Join our EU-funded MSCA network and explore evolution, ageing, and disease.
👉 www.evomg-dn.eu

📅 Apply by 30 November 2025

#PhD #DoctoralTraining #MSCA #HorizonEurope #Genomics #EvolutionaryBiology #BiomedicalResearch #EarlyCareerResearchers

6 months ago 8 13 0 2

Great PhD defence today of Lili Boll on combining large amounts of omics data to better understand Immune Checkpoint Inhibitor response!
@upf.edu @grib-barcelona.bsky.social

9 months ago 5 2 0 0

Great PhD defence today of Lili Boll on combining large amounts of omics data to better understand Immune Checkpoint Inhibitor response!
@upf.edu @grib-barcelona.bsky.social

9 months ago 5 2 0 0

Lili gave a talk entitled "Refining Immunotherapy Response Prediction in Advanced Bladder Cancer" related to the work recently published by the group in Nature Communications Check it out👇 👇
pubmed.ncbi.nlm.nih.gov/39979258/

10 months ago 2 1 0 0

XXIV Jornada de Biologia Evolutiva 2025 Data: 27 de juny de 2025 Lloc: Sala Prat de la Riba, IEC Organitza: Secció de Biologia Evolutiva de la SCB

📢 Join us for the XXIV Evolutionary Biology Conference!
🗓️ June 27, 2025
📍 Barcelona, Institut d’Estudis Catalans
🎙️ Invited speaker: Jérôme Salse (INRAE, France)
🏆 XVI Antoni Prevosti Award for young researchers
🔗 Info & registration: scb.iec.cat/xxiv-jornada...
#EvolBio2025 @scb.iec.cat

10 months ago 10 5 0 1

Translational activity of 80S monosomes varies dramatically across different tissues Abstract. Translational regulation at the stage of initiation can impact the number of ribosomes translating each mRNA molecule. However, the translational

Delighted to share paper on translational activity of 80S monosomes across different tissues in 🪰 in @narjournal.bsky.social thanks to fabulous team Albert Blandy Tayah Hopes Elton Vasconcelos @amy-turner96.bsky.social Bulat Fatkhullin Michaela Agapiou Juan Fontana academic.oup.com/nar/article/...

11 months ago 44 21 2 1

👀Last week (28-29 April), members of @grib-barcelona.bsky.social attended the Computational Genomics Symposium 2025 in Sant Feliu de Guixols, Girona!☀️💁‍♀️

@maralbalab.bsky.social @researchmar.bsky.social @prbb.org

11 months ago 2 2 0 0

2025 Decoding Microproteins Across Evolution and Disease Conference GRC The 2025 Gordon Research Conference on Decoding Microproteins Across Evolution and Disease will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.

Now is the time to reserve your spot for the 2025 Gordon Research Conference on #microproteins. Come join us in beautiful Barcelona in August!

www.grc.org/decoding-mic...

1 year ago 4 3 1 0

Thursday we will be hosting Jorge Ruiz-Orera at the PRBB 💥

1 year ago 2 0 0 0

The impact of human accelerated regions on neuronal development Human accelerated regions (HARs) are the fastest-evolving sequences in the human genome since the divergence from chimpanzees. Some of these regions a…

Our piece on the beautiful work by Cui et al. on the impact of human accelerated regions on neurons is out now!
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social

www.sciencedirect.com/science/arti...

1 year ago 5 5 0 0

Genome sequencing, assembly, curation, and downstream analyses Advances in long-read sequencing methods such as Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT) and scaffolding approaches using chromosome conformation capture have significantl…

🧪📣Course alert!📣🧪

Applications are open for the new edition of the @EMBO.org course on Genome assembly and downstream analysis in Florence 🇮🇹. We can’t wait to welcome a new group of participants after the success of🇧🇪 & 🇪🇸 editions.

🗓️ Apply by May 31.

🧪🧬🖥️ #EMBOgenomeSeq #ScienceTraining

1 year ago 9 7 0 0

Few weeks left to submit your abstract to #ESEB2025 in Barcelona!

👇
eseb2025.com

Do not miss this opportunity to present your most exciting work at the hot-spot #evolution event in Europe this year.

Choose among the 50+ symposia covering a broad range of topics!

1 year ago 27 19 0 0

Happy to see this out!

Integration of data from hundreds of patients to deepen our understanding of the molecular basis of the response to immunotherapy. Big team effort! @researchmar.bsky.social @upf.edu

1 year ago 3 1 0 0

Issue: Trends in Genetics

So many great reviews and perspectives in this month's special issue on #microproteins in @cp-trendsgenetics.bsky.social!

www.cell.com/trends/genet...

And just in time for tomorrow's @keystonesymposia.bsky.social on microproteins! #KSMicroproteins25 🎉🙌

1 year ago 9 3 0 0

🐦 Calling all Early Birds!

Hurry up and seize the opportunity to participate in the upcoming ESEB Congress, set in the vibrant city of Barcelona 🌟

🎟️ Secure now your place at the best possible price 👉🏻 eseb2025.com/registration...

#ESEB2025 #Biology #Evolution #Genomics

1 year ago 26 36 0 1

The new year starts with tenure-track openings at @UPFBarcelona @the_prbb

Computational Biology: upf.edu/ca/web/biome...
Quantitative Biology: upf.edu/ca/web/biome...

Check it out!

1 year ago 2 2 0 0

Posts by Mar Albà lab