New paper out: Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults.: Fischer, Larissa; Adams, Jenna N; Molloy, Eóin N.; et al.
Scientific reports Vol. 15, no. 1, p. 38499 Thanks for sharing! #dzne #papers
5/5 🧳
Our findings highlight region-specific differences in longitudinal rsFC strength between “normal” aging and early AD pathology and shed light on early changes in rsFC strength with AD pathology, which might already be disadvantageous for episodic memory performance in APOE4 carriers.
4/5💡
Longitudinal increase in rsFC strength between the anterior hippocampus and the superior precuneus is associated with higher early AD pathology. Higher rsFC strength was related to cognitive decline only in APOE4 carriers.
3/5 💡
Longitudinal decrease in rsFC strength within the posteromedial cortex and between the posterior hippocampus and the inferomedial precuneus was associated with “normal” aging. Pathology-independent lower rsFC strength was related to cognitive decline.
2/5 💡
In essence, hypoconnectivity was related to aging, hyperconnectivity was related to early Alzheimer’s pathology.
But which specific regions were involved?!
1/5 🔎
We investigated resting-state functional connectivity (rsFC) in episodic network regions over two years in cognitively normal amyloid- and tau-negative older adults (“normal” aging sample) and in older adults with CSF measurements (AD-biomarker sample).
I’m super happy about this project with Anne Maass, Jenna Adams, @sylviavilleneuve.bsky.social and the fantastic PREVENT-AD team!
Are you interested in distinguishing region-specific longitudinal changes in resting-state functional connectivity related to “normal” aging and to early Alzheimer’s pathology?
Then keep reading about your preregistered study and our fresh preprint! 🧠
www.biorxiv.org/content/10.1...
I‘m so proud of this team effort, thanks Nick for sharing it here! 😊