*New preprint* Brian Galaviz Sarmiento shows how the developmental regulation of kinetochore phosphorylation impacts mitotic fidelity of pluripotent stem cells. Lots of new insights!
www.biorxiv.org/content/10.6...

Calling all stem cell researchers!

We are seeking a research scientist to join our group and develop technology culturing pluripotent stem cells using tissue mimetic substrates. This is a 2 year funded opportunity. Details and instructions on how to apply: apply.interfolio.com/169153

Cell competition eliminates aneuploid human pluripotent stem cells Ya et al. show that, unlike somatic cells, hPSCs have an intrinsic capacity to survive and proliferate with an aneuploid genome. Rather, in mosaic populations, MYC- and p53-mediated cell competition b...

Check out our latest work!

Amanda Ya and Chenhui Deng discover that (1) human pluripotent stem cells (hPSCs) tolerate being aneuploid but (2) in mosaic populations, aneuploid hPSCs are less fit relative to diploid cells and are eliminated by cell competition to maintain their genome integrity.

An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity Kucharski et al. identify a new signaling pathway in mitosis whereby Aurora kinase A phosphorylates BOD1L1 to increase protein phosphatase activity toward kinetochore substrates to facilitate high mit...

Check out the latest on chromosome instability from @comptonmitosis.bsky.social!

An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity: Cell Reports www.cell.com/cell-reports...

It's official! Congratulations to Dr. Amanda Ya on passing her thesis defense! So proud of all your hard work and accomplishments.

Please join for Amanda Ya's upcoming thesis seminar. Looking forward to a fantastic talk on cell competition between diploid and aneuploid stem cells!

Thanks to Minji Jo and Ryota Uehara for organizing a fantastic session on the causes and consequences of ploidy alterations at MBSJ this year! It was great to hear about all the exciting research going on.

Thank you to Minji Jo and all the group members of Toru Hirota's lab at the Japanese Foundation for Cancer Research. It was an amazing day of meeting new colleagues, sharing research, and making new connections! Next up MBSJ 2024!