Congratulations to Dr. Adam Marc, the latest minted PhD from Jefferson Neuroscience! He did lovely work in the Hahn and Borgmann-Winter labs on proteomics and schizophrenia and marvelously defended his thesis today!
A podcast I did previewing my Plenary talk at this years World Parkinsons Congress was just released. The podcast is called Hear! Here! Parkinson’s and originated in Norway. It us co hosted by Eli Pollard and Edgar Valdmanis.
It can be heard at www.podbean.com/ew/pb-sdvz8-....
All ready for 3 days of exciting talks and discussions with our colleagues from Rome and Tel Aviv on topics ranging from Parkinson’s disease, ALS, stroke, epilepsy and immunology.
I just had the great honor of speaking with George Ackerman whose advocacy for Parkinson's disease has been tremendous. Our conversation about the role of viruses and PD on his TogetherFor Sharon podcast is available on Spotify.
open.spotify.com/episode/4ZSJ...
@raskin.house.gov giving a great and inspirational speech at Philadelphia’s No Kings rally. People from Independence Hall to the Constitution Center.
Appropriate place to end the Philadelphia No Kings march
Our paper discussing templating of alpha-synuclein and how over expression of monomeric (normal) forms of this protein can induce misfolding and induce SNpc DA neuron death was just published in Scientific Reports.
nam10.safelinks.protection.outlook.com?url=https%3A...
A naturally neurotropic virus that kills dopamine neurons. But not to worry, because If we don’t know about it then it’s not real.
Very honored to have given this Rising Star interview, where I could talk a bit about myself, my research, my passion for microscopy, and my dream to help find a cure for #LongCovid one day 💔
Link for the full interview: short-link.me/123uR
Press release:
www.eurekalert.org/news-release...
On this Flag day, let’s remember that this country, founded by immigrants, is made great by the rainbow of people and opinions that strive for a more perfect union. Patriotism is not owned by one group and despite efforts at this small blip in time never will be.
The NIH has continued to refine its policies and guidelines to address the "effect of sex" in research, even extending these requirements to preclinical and animal studies in 2016.
The NIH Revitalization Act of 1993, signed into law on June 10, 1993, directed the National Institutes of Health (NIH) to establish guidelines requiring the inclusion of women and minorities in clinical research.
Slightly exaggerated but not long ago almost all preclinical/clinical studies used only males assuming that results would be the same in females. We now know (amazing, huh) that our biochemistries are different and why the NIH mandated that all studies used equal numbers of male and females.
Not a problem. We can just start studying the effects of loss is estrogen leading to menopause in males. Just like the good old days when all studies were done in males (he says dripping with sarcasm)
Congratulations to 4 of our @ParkinsonDotOrg Center of Excellence movement disorder physicians, Drs Tsao-Wei Liang, Daniel Kremens and Jeffrey Ratliff (neurology) and Ashwini Sharon (neurosurgery) on being named 2025 top docs by Philadelphia magazine.
Congratulations Jefferson JCLS Class of 2025! Proud of all our Neuroscience graduates and their accomplishments on the road to their PHD, MD, and MS degrees! What a wonderful group of new scholars!! Mazel Tov!
Tim Mosca, PhD (Associate Professor). Not pictured: Joesph Buchler III MS, Benjamin Helpin, MS, Darsaan Khanna, MS).
Victoria Baccini PhD (Class of 2025, Dalva lab), Oghenerukevwe Akpoghiran, PhD (Class of 2025, Koh lab), Kyunghee Koh, PhD (Professor), Gabriella Spagnuolo, PhD (Class of 2025, Iacovitti Lab),, Lorraine Iacovitti, PhD (Professor), Jesse Humenik, MS (Class of 2025, Mosca lab),
Congratulations to the 2025 Department of Neuroscience graduating class. From L to R: Richard Smeyne, PhD, Professor and Chair, Hanni Jafri, MD, PhD (class of 2025, Dalva lab), Matthew Dalva, PhD (currently, Professor, Tulane University),
Very cool
Jeffery Taubenberger, who gained fame for unearthing samples of the 1918 flu virus, and ultimately sequencing its entire genome, has been named acting director of the NIAID, Science has learned. scim.ag/3EzzUBo
On the positive side, WT animals vaccinated against the COVID-19 infection, using either mRNA or protein-based vaccines were protected from this increased sensitivity to oxidative stress. G2019S LRRK2 animals, however, were only protected by the protein vaccine and not the mRNA vaccine.
Using preclinical modeling, we show that SARS-CoV-2 infection sensitizes the dopamine neurons lost in Parkinson's to oxidative stress that in an unaffected animal would be innocuous. We also show that animals carrying a G2019S LRRK2 mutation lose these same DA neurons following infection alone.
Our paper examining the role of SARS-CoV-2 infection and its link to the development of Parkinson's disease has been published online in npj Parkinsons's disease. The article is open access. rdcu.be/ei1I6.
We are excited to announce the next Journal of Virology seminar series will be live streamed on March 28 at 11 am Central Time. The paper to be presented is journals.asm.org/doi/10.1128/... by Dr. Christine Marizzi and her group asm.org/Biographies/...
One of my favorite poems!
I don’t normally post about politics and I say this as an older white male. We need to get rid of this older generation of Dems. We need new vigor to fight for our beliefs. The current admin will keep winning because Crazy has a lot of Energy.
But you are right. Optic nerve directly to brain. So iaee other cranial nerves: olfactory (from nose), trigeminal from mouth, facial (tongue), glosspharyngeal (tongue/thriat) hypoglossal (uvula). Then there is vagus from visceral organs. Many roads to the brain.
One reason (for some) that there is only conjunctivitis might be some cross protection from flu vaccine and previous flu immune memory. This might be from the previous clade and not the newest infecting cows, cats and now rodents.
I find this sad. From Von Economo’s encephalopathy (made famous in Oliver Sacks “Awakenings”) after 1918 flu to 2003 H5N1 to the 2009 H1N1 swine flu, viruses seem to be the trigger for neurodegeneration. While not the only cause; to ignore their contribution to lose a whole entree to prevention.