Looking forward to seeing you all at the #aECM club today!👇

Exciting news:
Our RNA community in @uniregensburg.bsky.social is set to grow!

We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network.

Details & application 👇

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here:
mbg.au.dk/en/news-and-...

Join us 👇. Together with our CompBio and Proteomics platforms, we'd love to work with you on examining protein dynamics!

🚀 We’re hiring! The Structural Biology Platform is seeking a Project Leader to advance cryo-electron tomography and expand capabilities at the FMI. Join a vibrant research community at the interface of structural biology, cell biology & disease mechanisms. Apply at: www.fmi.ch/education-ca...

👩‍🔬 On February 11, to mark the International Day of Women and Girls in Science, we’re hosting a panel discussion on how scientific progress and gender equality can advance together. The panel brings together voices from academia, industry, and EDI. Join us for this important conversation!
#IDWGS

How a sweet treat can change memories Memories must be flexible so animals can adapt when the world changes. FMI neuroscientists found that in fruit flies, simply tasting a sugar reward again can weaken all previous associated memories. T...

Now out in @currentbiology.bsky.social: neuroscientists in the lab of @felsenberg.bsky.social found that in fruit flies, re-tasting a sugar reward can weaken past memories, pointing to new ways to safely update harmful ones. www.fmi.ch/news-events/...

Very thankful for this thoughtful dispatch by @shaisrael.bsky.social sky.social and Moshe Parnas about our work. Learning and memory: Forgetting to remember: Current Biology www.cell.com/current-biol...

FMI Year in Review 2025 Our annual brochure highlighting the FMI’s key scientific publications, major events, and facts & figures from the past year is now available. Discover the highlights of 2025, a year that marked the F...

Our annual brochure “Year in Review” is out now! It highlights the FMI’s key scientific publications, major events, and facts & figures from 2025, a year that marked our 55th anniversary.
www.fmi.ch/news-events/...

Congratulations, Fiona!

Prof. Fiona Doetsch has been awarded the 2026 Louis-Jeantet Prize for Medicine!
Her discoveries reveal how neural stem cells support lifelong brain plasticity and repair. 🧠
Read more: www.biozentrum.unibas.ch/news/detail/...

RNA-binding proteins function through network effects, coordinately binding and weakly regulating many transcripts – or don’t they? Read our new preprint on how LIN28 controls developmental timing through only two targets, one mRNA, one miRNA. doi.org/10.64898/202...

Please repost - position of Head of Student & Postdoc Affairs available at our Institute in the heart of Europe (Basel, Switzerland) 👇

Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...

Switzerland is joining Horizon Europe!

We are uniting two research powerhouses.

For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.

Today is a good day for science, and for our EU-Switzerland partnership.

And we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!

One clock, two functions: from daily rhythms to development Scientists at the FMI and the University of California-Santa Cruz have found that similar molecular machineries control daily circadian rhythms and developmental timing. Their work in worms shows that...

Now in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...

Programme of the upcoming TriRhena Gene Regulation Club in Basel on November 5, 2025 https://www.ie-freiburg.mpg.de/gene-regulation-club

Here is the schedule for the next TriRhena Gene Regulation Club at the FMI @fmiscience.bsky.social in Basel 🇨🇭 next week (5 Nov 2025; 14:00-18:45).

Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).

www.ie-freiburg.mpg.de/grc

"[In C. elegans] researchers uncovered key principles of cell death and RNA interference [that] paved the way for new therapies and technologies. These breakthroughs were made not because they were sought by design, but because a few scientists, supported by public grants, followed their curiosity"

For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Nektarios Tavernarakis on why curiosity-driven research, not focusing on application, is fundamental to problem solving and requires government support in @emboreports.org doi.org/10.1038/s443...

Bull’s-eye! Static electricity pulls worm through air to its insect victim Electrostatic charges may help roundworms infect a wide variety of hosts

Flying worms! www.science.org/content/arti... (And I always wondered how worm cuticular alae (= wings) got their name 😉)

🔬 Next in the NCCR RNA & Disease Seminar Series: Prof. Olivia Rissland (Univ. of Colorado School of Medicine, USA)!

📅 27.10. 16:30 – University of Bern, DCBP
📅 28.10. 15:00 – ETH Zurich, Hönggerberg

👉 More info: nccr-rna-and-disease.ch/education/nc...

@unibe.ch @ethz.ch @snf-fns.ch

For what it’s worth, The Wyoming Worm lab has funding for 5 years along with exciting projects with solid foundations. We are is still looking for capable, dedicated, and fun-to-work-with lab members at all career stages. davidfay@uwyo.edu

scholar.google.com/citations?us...

Fabulous @katb92.bsky.social was the lead on our side!

Old cogs, new clocks: a conserved protein complex controls developmental and circadian timing | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

This invites speculations about the evolution of circadian vs. developmental clocks and the features that make the PER/LIN-42:CK1/KIN-20 module so central to different timing mechanisms – as discussed in the accompanying News & Views article @embojournal.org doi.org/10.1038/s443... . 8/n

Intriguingly, this tango also appears to happen in circadian clocks: while CK1 licenses PER for degradation, PER also regulates CK1 activity and its targeting of the CLOCK protein in the nucleus. 7/n

Indeed, KIN-20 exhibits dynamic localization to the nucleus – dependent on LIN-42 binding. We speculate that this may provide KIN-20 to access to additional substrates. 6/n

Animals lacking CK1/KIN-20 or its enzymatic activity are highly arrhythmic – in fact much more so than animals only lacking the LIN-42_CK1BD. This made us wonder whether the key function of the complex is regulation of KIN-20 by LIN-42, rather than the other way around. 5/n

LIN-42 co-immunoprecipitates KIN-20 – an orthologue of Casein Kinase 1delta/epsilon that also occurs in a complex with PER in mammals. The LT/SYQ region forms a CK1-binding domain (CK1BD) that also regulates CK1 activity. CK1 phosphorylates LIN-42. 4/n

Its most conserved feature are the PAS (PER/ARNT/SIM) domains – but we find them to be dispensable for rhythmic molting. Instead, a less conserved region previously termed LT/SYQ for an amino acid signature is required. 3/n