Small molecule oxybutynin rescues proliferative capacity of complex III-defective muscle progenitor cells | American Journal of Physiology-Cell Physiology | American Physiological Society Mitochondrial disease encompasses a group of genetically inherited disorders hallmarked by an inability of the respiratory chain to produce sufficient ATP. These disorders present with multisystemic p...

Excited to share our recent publication where we identified the small molecule oxybutynin that can overcome severe complex III mitochondrial dysfunction in primary muscle progenitor cells. @cornelluniversity.bsky.social

Check out the full story here: journals.physiology.org/doi/full/10....

The Mitochondrial Brown Adipose Tissue Maintenance Factor Nipsnap1 Interfaces Directly With the β-Oxidation Protein Machinery in Rodents The activation of brown adipose tissue (BAT) is associated with improved metabolic health in humans. We previously identified the mitochondrial protein Nipsnap1 as a novel regulatory factor that integ...

Sharing our newest publication where we show that the brown fat maintenance regulatory factor Nipsnap1 directly interacts with the mitochondrial beta oxidation machinery to regulate lipid energy homeostasis! Learn more here: jn.nutrition.org/article/S002...

So excited to present our work at the Goodman Cancer Institute at McGill University this week. I am looking forward to connecting with all the excellent scientists at McGill. Thanks @kazaklab.bsky.social for the invite!

Excited to present our work at the Adipose Biology Seminar Series (ABSS) hosted by @kazaklab.bsky.social and colleagues at McGill, UToronto, and SickKids

Headshots of the winners of the 5th Annual Rising Black Scientists Awards Jheannelle Johnson of Stanford and Howard University, Victor Ekuta, MD, of the Morehouse School of Medicine, Kenna Gloria Agbugba of Philander Smith University, & Nyasha Milanzi pf Michigan Technological University. Sponsored by Cell Press, Cell Signaling Technology, and the Elsevier Foundation

We are proud to announce the winners of the 5th annual Rising Black Scientists Awards! www.cell.com/news-do/risi...

Learn more about each winner and their essays now published in @cp-cell.bsky.social below. 🧵

Sponsored by #CellPress, @cellsignal.bsky.social, and @elsevierconnect.bsky.social

Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity - Nature Cell Biology Latorre-Muro et al. show that the cytosolic chaperone PPID drives insertion of the mitochondrial import receptor TOM70 into the mitochondrial outer membrane, thereby regulating body temperature, gluco...

💫NEW by @ppuigserverb.bsky.social & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane, regulating body temperature, glucose homeostasis and body weight in #obese mice.
👉https://rdcu.be/d8atv
www.nature.com/articles/s41...

Cornell University - College of Human Ecology on LinkedIn: A project led by Joeva Barrow, Ph.D., R.D., assistant professor in the… A project led by Joeva Barrow, Ph.D., R.D., assistant professor in the Division of Nutritional Sciences at Cornell, aims to investigate whether eating proteins…

This is a project that is near and dear to my heart. So grateful to receive funding to tackle disparities in nutrition. nam12.safelinks.protection.outlook.com?url=https%3A...

Mitochondrial heterogeneity and adaptations to cellular needs - Nature Cell Biology Granath-Panelo and Kajimura review emerging evidence of mitochondrial heterogeneity in different contexts and discuss how mitochondrial malleability contributes to cell fate determination and tissue r...

☕This year Granath-Panelo and Kajimura reviewed evidence of #mitochondria heterogeneity in different contexts and discussed how mitochondrial malleability contributes to cell fate determination and tissue remodeling.
👉https://rdcu.be/d5gHT
www.nature.com/articles/s41...

The Mitochondrial Brown Adipose Tissue Maintenance Factor Nipsnap1 Interfaces Directly with the Beta-Oxidation Protein Machinery. Background: The activation of brown adipose tissue (BAT) is associated with improved metabolic health in humans. We previously identified the mitochondrial protein 4-Nitrophenylphosphatase Domain and ...

Check out our latest preprint by the fabulous @peiyintsai.bsky.social where we describe the first protein-protein binding network of the mitochondrial protein Nipsnap1 and how it interfaces with lipid metabolism in BAT. www.biorxiv.org/content/10.1...

Happy Holidays from the Barrow Lab!

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Small molecule oxybutynin rescues proliferative capacity of complex III-defective MPCs Mitochondrial disease encompasses a group of genetically inherited disorders hallmarked by an inability of the respiratory chain to produce sufficient ATP. These disorders present with multisystemic p...

Sharing our most recent preprint co-led by @kaydine.bsky.social! Here we discovered the small molecule oxybutynin chloride via high-throughput screening approaches that can overcome complex III mitochondrial dysfunction in primary muscle stem cells (MuSCs). www.biorxiv.org/content/10.1...

Thank you! 🤗

AQP1- A regulatory factor associated with brown adipose tissue-silencing The activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) by environmental cold challenge yields strong metabolic benefit in the face of diet-induced obesity (DIO). Yet, a crit...

Check out our most recent preprint from @chloecheng.bsky.social under review at AJP Endocrinology and Metabolism. Here we identify the protein and putative brown fat silencer Aquaporin 1 (AQP1) that is only expressed when brown fat is inactive. Read more here: www.biorxiv.org/content/10.1...

Celebrating our forth alumna from the Barrow lab: Dr. Chloe Cheng, Ph.D. @chloecheng.bsky.social 🥳 Chloe obtained her Ph.D. in Biological and Biomedical Sciences with a concentration in metabolism from Cornell University and is now interviewing for postdoctoral positions. Congrats Chloe!!