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Posts by Caroline Kikawa

So honored to have received this award! Thank you to the Experiement Foundation and @navigation.org

2 months ago 3 1 0 0
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We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza.

Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.

2 months ago 76 37 1 1
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Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025 The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...

In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains

Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...

7 months ago 60 35 1 1
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High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains Human influenza viruses rapidly acquire mutations in their hemagglutinin (HA) protein that erode neutralization by antibodies from prior exposures. Here, we use a sequencing-based assay to measure neu...

In study led by @ckikawa.bsky.social & Andrea Loes, we use new assay to measure ~10,000 neutralization titers to recent influenza strains & show titers correlate w evolutionary success of viral strains

Similar data could help forecast evolution for vaccine selection

www.biorxiv.org/content/10.1...

1 year ago 63 16 1 2