Posts by Patrick Moynihan
New work from my team: pubs.acs.org/doi/10.1021/...
We used probes to ID targets of carbapenems in M. abscessus. 17 targets active in both carbon starved and replicating cultures. Includes validation of 9 targets. Part of a special issue ("NTM Pathogens – Biology, Infection, and Drug Discovery).
Lovely to visit. Thanks for listening!
Wonderful to have @pmoyniha.bsky.social from Western University, Canada (hosted by @lislowe.bsky.social) giving a @mhd-newcastle.bsky.social seminar @medicalsciencesncl.bsky.social @newcastleuni.bsky.social #mycobacterium #tb #cellwalls
Each publication in a #Microbio26 journal helps fund 4 student travel grants. Please publish with us if you can!
Beautiful!! Will have to visit some time.
Always nice to have the chance to visit a UNESCO site. Giant’s Causeway, NI.
Looking forward to attending the @microbiologysociety.org annual general meeting in Belfast. I'll be speaking in the Mycobacteria session on Tuesday. Also plenty of posters from the group!
If you are working on staphylococci you might want to travel to Banff this September
banff.isssi2026.com/event/ISSSI/...
Track saw?
But I agree. It should start from the “normal” and then reinforce by teaching the exceptions.
Biology always there to spoil rules. Leaderless transcripts quite common in mycobacteria.
www.pnas.org/doi/10.1073/...
If you ever need lto be convinced by how bad the "Contributed by" track is at @pnas.org ...
Only author: David Lipman, handling editor: David Lipman. Only integrity-free person not embarrassed by such a paper: David Lipman.
Even uses "I did" in the abstract. Shameful.
Please Repost 🔄
Global Staphylococcus research community is heading to the Canadian Rockies!
Join the 20th International Symposium on Staphylococci and Staphylococcal Infections
📅 September 20–24, 2026
📍 Banff Centre for Arts and Creativity, Banff, Canada
#ISSSI2026
#Staphylococcus
PSA: If you are thinking about putting a 3D data plot into an output that will primarily be viewed in 2D, don't.
I should add this is just the tip of the iceberg. Plenty more to come on this story from our group, @proftracypalmer.bsky.social, @lislowe.bsky.social and others. There is such an astonishing diversity of toxins in these bacteria and so much we don't yet fully understand.
A Type VII-secreted toxin enables inter-mycobacterial competition www.biorxiv.org/content/10.64898/2026.03...
*objectively.
well done Sam.
Cartoon representing the mycobacterial oxidative phosphorylation system, including cytochromes, NDH-2, and ATP synthase. Taken from Figure 1 of the article.
#Microbiology
The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear
Here the authors clarify how bedaquiline works
@jnblab.bsky.social @morwan.me
#TBSky #antibiotics #AMR
http://dlvr.it/TQjZ0W
We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...
With the rumblings around CIHR wanting to move to one cycle per year not going away, in consultation with a diverse stakeholder group, we have put together a letter for CIHR leadership. Please consider signing this letter and share/RT: docs.google.com/forms/d/e/1F... @cannabrain.bsky.social
I feel that today 🤣😂
Thanks. Same!
This job really knows how to ruin your day sometimes.
Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com
www.jobs.ac.uk/job/DQY475/r...
QR code to access 'Structural diversification of phage tail fibres enables recognition of diverse type IV pili'
New paper showing how tailed #phages recognize diverse #Pseudomonas #T4P! Outstanding work by PhD candidate Ikram Qaderi, building on work started a decade ago during my sabbatical in the McArthur lab and in collaboration with the Guarné lab, now at #McGill. @mcmasteriidr.bsky.social
When it rains myco publications in pours myco publications!
Now out in PNAS tinyurl.com/2a6833n4
When @zestytoast.bsky.social accidentally isolated the long-chain acyl-CoA carboxylase, we quickly realized we were looking at a fascinating machine essential for building the mycobacterial membrane...
Out now in EMBO J ahead of World #TB day!
Our friends at the TB Drug Accelerator identified EtfD as a high-priority target for fast acting treatments so @courbongautier.bsky.social jumped into action.
Our EtfD assay & struct are already being used to help find new therapeutics
tinyurl.com/3cb2j5k9
Ah gotcha. Best of luck and welcome to Canada when you get here!
No judgement whatsoever. We moved from the UK to Canada despite much better funding options there. Just sharing that the situation in Canada for research is currently not great.