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Posts by Max Gutierrez

IRB Barcelona invites applications for Group Leader positions in Chemical
Biology (one) and Structural Biology (one) as part of its strategic effort to
strengthen molecular sciences.
The successful candidates will join a highly multidisciplinary and collaborative
institute with strong expertise in cancer and metastasis, ageing and cell
reprogramming, metabolism, cell differentiation, signal transduction, and gene
expression, working at the interface of structural and computational biology,
chemistry, and biology.
IRB Barcelona is embedded in a vibrant scientific ecosystem and maintains
close collaborations with major research infrastructures such as the Barcelona
Supercomputing Center (BSC) and the ALBA Synchrotron, as well as leading
research centres, universities, and hospitals in Barcelona.

About IRB Barcelona
IRB Barcelona
(www.irbbarcelona.org)
is a multidisciplinary research
institute where scientists collaborate
to address fundamental biomedical
questions and unmet medical needs.
The Institute currently hosts more
than 500 members from around the
world across 27 research groups.
How to apply
Applications should include a CV, letter
of intent, brief (2-page) research
proposal, and the names and contact
details of at least three referees.
Applications must be submitted via
https://recruitment.irbbarcelona.org
no later than 22 May 2026, quoting
reference GL/26/01 (Chemical Biology)
or GL/26/02 (Structural Biology).
The successful candidates are expected
to join in Q4 2026 or 2027, with flexibility
depending on individual circumstances.
For Informal enquiries, please contact
the chair of the Search Committee
(Prof. Xavier Salvatella, at
xavier.salvatella@irbbarcelona.org)
and for details and updates on
the selection process please
contact the Head of People at
(irbglcall@irbbarcelona.org)

IRB Barcelona invites applications for Group Leader positions in Chemical Biology (one) and Structural Biology (one) as part of its strategic effort to strengthen molecular sciences. The successful candidates will join a highly multidisciplinary and collaborative institute with strong expertise in cancer and metastasis, ageing and cell reprogramming, metabolism, cell differentiation, signal transduction, and gene expression, working at the interface of structural and computational biology, chemistry, and biology. IRB Barcelona is embedded in a vibrant scientific ecosystem and maintains close collaborations with major research infrastructures such as the Barcelona Supercomputing Center (BSC) and the ALBA Synchrotron, as well as leading research centres, universities, and hospitals in Barcelona. About IRB Barcelona IRB Barcelona (www.irbbarcelona.org) is a multidisciplinary research institute where scientists collaborate to address fundamental biomedical questions and unmet medical needs. The Institute currently hosts more than 500 members from around the world across 27 research groups. How to apply Applications should include a CV, letter of intent, brief (2-page) research proposal, and the names and contact details of at least three referees. Applications must be submitted via https://recruitment.irbbarcelona.org no later than 22 May 2026, quoting reference GL/26/01 (Chemical Biology) or GL/26/02 (Structural Biology). The successful candidates are expected to join in Q4 2026 or 2027, with flexibility depending on individual circumstances. For Informal enquiries, please contact the chair of the Search Committee (Prof. Xavier Salvatella, at xavier.salvatella@irbbarcelona.org) and for details and updates on the selection process please contact the Head of People at (irbglcall@irbbarcelona.org)

Was just asked to spread the word about this position.
Structural biology and Chemical Biology positions in Barcelona, one of the great cities of the world!
www.irbbarcelona.org/sites/defaul...

1 day ago 14 18 0 0
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The time has come for big changes to research funding. New piece by RoRIโ€™s Peter Kolarz on why incremental fixes may no longer be enough: journals.plos.org/plosbiology/...

1 week ago 3 4 1 2
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Urban and rural prevalence of tuberculosis in low- and middle-income countries: A systematic review and meta-analysis In a systematic review and meta-analysis, Seyed Alireza Mortazavi and colleagues investigate urban versus rural differences in adult pulmonary tuberculosis prevalence between 2000 and 2024 in 26 low- ...

In this systematic review & meta-analysis, Mortazavi & colleagues (@petermacp.bsky.social) investigate urban vs rural differences in #TB prevalence between 2000 and 2024 in 26 low- and middle-income countries, finding that TB epidemics have become increasingly urbanized ๐Ÿงช #MedSky
plos.io/3O79BqY

1 week ago 6 4 0 1

We are looking for an experienced light microscopy specialist, motivated to support our users in the Advanced Light Microscopy Facility at EMBL Heidelberg.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j... -closing date 11 May 2026 @eurobioimaging.bsky.social @globalbioimaging.bsky.social

6 days ago 34 35 0 2
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Caยฒโบ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...

๐Ÿ’ฅOur latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al!
link.springer.com/article/10.1...

3 weeks ago 25 15 0 0

โ€ผ๏ธ A really good meeting for people working on host-pathogen interactions! Great keynote speakers this year: Raphael Valdivia and Florence Niedergang. Please repost!

3 weeks ago 4 7 0 0
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Now this is the future of TB research ๐Ÿ‘

39 Keystone Symposia & @gatesfoundation.bsky.social scholarship awardees at #KSTB26.

With ~1.5M TB deaths each year, these early-career scientists are driving progress through collaboration and new ideas.

@maxgg.bsky.social @breealdridge.bsky.social

3 weeks ago 13 7 0 0
Activation of l-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis - Nature Communications Here, the authors report metabolic activation as a potential antimicrobial strategy against Mycobacterium tuberculosis. They show that supra-physiological activation of L-histidine biosynthesis r...

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy?

Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation.

www.nature.com/articles/s41...

(1 out of 3)

3 weeks ago 67 32 6 2
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Yes! We Can End TB! Lead by Policy! Powered by Human-Relevant Science! "We know how to live in a world without tuberculosis. But we choose not to live in that world.

We know how to end TB. Whatโ€™s missing is the will to change the systems that keep it spreading. Ahead of #WorldTBDay, SAO is highlighting an overlooked TB risk, the international monkey trade, & why humanโ€‘centered research is a better (safer) path forward.

๐Ÿ”— www.linkedin.com/pulse/yes-we...

4 weeks ago 5 1 1 1

โ€œMeasures to strengthen international biosafety and biosecurity practicesโ€

There is an absolute necessity for research on โ€˜pandemic-prone pathogensโ€™. Studies must, however, be conducted responsibly & according to strict principles of safety & security

This outlines steps for global accountability

1 month ago 2 4 0 0

Very interesting and important work. When we found that antibiotics can accumulate in organelles we speculated that this could be the case for other drugs in other diseases - and you show this here! Congratulations everyone

1 month ago 0 0 1 0
Cryo-EM maps and atomic models of the biotin-containing 3-methylcrotonyl-CoA carboxylase (MCC) complex and long-chain acyl-CoA carboxylase (LCC) complex

Cryo-EM maps and atomic models of the biotin-containing 3-methylcrotonyl-CoA carboxylase (MCC) complex and long-chain acyl-CoA carboxylase (LCC) complex

New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but gotโ€ฆ something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
๐Ÿงต
tinyurl.com/ukny4ptz

5 months ago 89 30 4 2

Very excited to share our recently published work on NTM and their response to acid stress!

As my first paper, Iโ€™m especially grateful for the support and guidance from @luizcarvalholab.bsky.social , Rachel and @maxgg.bsky.social . More to come!

1 month ago 13 5 0 0

Great to see this. Many years ago I found a complete set of >100 years of Quarterly Journal of Microscopical Science (predecessor to J Cell Sci) in a Dutch antiquarian book store. We scanned these as PDFs but COB have now converted the full archive to HTML ๐Ÿ‘

1 month ago 42 8 1 0
Screenshot of the title and author list of the preprint entitled "Deep learning extracts MoA-specific signatures from high-throughput images of chemically and genetically perturbed Corynebacteria"

Screenshot of the title and author list of the preprint entitled "Deep learning extracts MoA-specific signatures from high-throughput images of chemically and genetically perturbed Corynebacteria"

Our preprint outlining a deep learning-based phenotypic screening approach for the discovery of new TB drugs is out on bioRxiv now ๐Ÿ’Š๐Ÿฆ 

๐Ÿ”— doi.org/10.64898/202...

Thank you @awehenkel.bsky.social @chzimmer.bsky.social @spetrella.bsky.social @curieuseny.bsky.social and everyone else not on bsky (yet)๐Ÿ™

1 month ago 17 10 1 1
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Iโ€™m pleased ๐Ÿค— to share our new preprint exploring the mode of action and resistance of the antitubercular drug pyrazinamide (PZA) ๐Ÿ’Š Thanks to everyone who have participated ๐Ÿ™Œ
We hope these findings will help the fight against drug resistance in tuberculosis.
www.biorxiv.org/content/10.6...

1 month ago 32 20 4 0
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Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...

We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.

First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social

rdcu.be/ezBl7

8 months ago 73 22 3 3

Thanks a lot Alex!๐Ÿ™

1 month ago 0 0 0 0
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Beyond the exciting findings, an interesting fact to me in this project was how different are mycobacteria at the time of transformation and how better protocols are needed as there is no one-fits-all. Congratulations everyone!

1 month ago 3 0 1 0

This was a great collaboration with our longstanding collaborators @luizcarvalholab.bsky.social and Rachel Lai (not on Bluesky?!)- Luiz has a compelling collection of mycobacteria (!!) and we only picked 12 this time...๐Ÿ˜…

1 month ago 3 0 1 0

She found that many NTMs are restricted by low pH in macrophages. The data suggest that specific environmental adaptations may determine the opportunistic potential of NTMs. Parise's work also discovered some beautiful cell biology of NTMs in human macrophages that we are exploring. Stay tuned!

1 month ago 1 0 1 0
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Acidic pH Restricts Nonโ€Tuberculous Mycobacteria Replication Different nontuberculous mycobacteria (NTM) species display unique replication profiles in acidic pH inย vitro which correlates to their replication within human macrophages. Inhibition of the acidic ...

Very happy to see this out! Great work by @lockwop.bsky.social @crick.ac.uk and first paper on NTMs from the lab! Parise made a set of 12 fluorescently labelled NTMs covering environmental and opportunistic mycobacteria...
onlinelibrary.wiley.com/doi/10.1111/...

1 month ago 45 15 2 2
KSQA: Dr. Max Gutierrez  (Tuberculosis)
KSQA: Dr. Max Gutierrez (Tuberculosis) YouTube video by KeystoneSymposia

๐Ÿ”ฌ TB, infectious disease & global health researchers: Save $250 by registering for the Keystone Symposium on Tuberculosis by Jan 22 (11:59 PM MST). Join leaders in TB biology & global health. ๐ŸŽฅ youtu.be/4L_N79rDCfw
๐Ÿ”— keysym.us/KSTB26
@maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #TBResearch

3 months ago 3 3 0 0
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab

2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...

2 months ago 30 40 0 1
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab

Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026

2 months ago 26 29 0 4
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Continuum architecture dynamics of vesicle tethering in exocytosis Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

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๐Ÿฅณ our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaรฑo-Dรญez labs #Quantitative_Cell_Biology

Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...

3 months ago 56 29 6 5

Congratulations Oriol and the team! Beautiful work!๐Ÿ‘

3 months ago 1 0 1 0

Interested to see what each face will give you after swabbing and doing CFUs

3 months ago 1 0 1 0
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๐Ÿฅณ ๐„๐ฑ๐œ๐ข๐ญ๐ž๐ ๐ญ๐จ ๐ฌ๐ก๐š๐ซ๐ž ๐จ๐ฎ๐ซ ๐ฅ๐š๐ญ๐ž๐ฌ๐ญ ๐ฐ๐จ๐ซ๐ค ๐ฌ๐ก๐จ๐ฐ๐ข๐ง๐  ๐ก๐จ๐ฐ ๐ฉ๐จ๐ฅ๐ฒ๐ฌ๐ข๐š๐ฅ๐ฒ๐ฅ๐š๐ญ๐ข๐จ๐ง, ๐š ๐ซ๐š๐ซ๐ž ๐ฉ๐ซ๐จ๐ญ๐ž๐ข๐ง ๐ฆ๐จ๐๐ข๐Ÿ๐ข๐œ๐š๐ญ๐ข๐จ๐ง, ๐ซ๐ž๐ ๐ฎ๐ฅ๐š๐ญ๐ž๐ฌ ๐ข๐ง๐Ÿ๐ฅ๐š๐ฆ๐ฆ๐š๐ญ๐จ๐ซ๐ฒ ๐ฆ๐จ๐ง๐จ๐œ๐ฒ๐ญ๐ž ๐ฆ๐จ๐›๐ข๐ฅ๐ข๐ณ๐š๐ญ๐ข๐จ๐ง ๐Ÿ๐ซ๐จ๐ฆ ๐ญ๐ก๐ž ๐›๐จ๐ง๐ž ๐ฆ๐š๐ซ๐ซ๐จ๐ฐ.

โœ๏ธ Aurรฉlien Boyancรฉ, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social

๐Ÿ“– shorturl.at/IDwza

๐Ÿ‘‡ A short thread...

3 months ago 19 10 2 1

A great meeting ahead for host and pathogen aficionados! Keynote speakers: Florence Niedergang (Cochin) and Raphael Valdivia (Duke)- plenty of opportunities for early career researchers to present their work and a very collegial and supportive network. Belfast here we go! Please repost.

3 months ago 6 4 0 0