Great episode. Although I might be in that Orwell-as-a-BS-detection-muse group that comes under a bit of David’s fire ….

NEW EPISODE OUT NOW!

Today is the 1st in a new series about how the greatest political writer of the 20th century, George Orwell, responded in real time to the epochal events of WWII. What did he get right, what did he get wrong & what did he fail to understand at all?

Find us at...🎧 ppfideas.com

Title card for Mindscape podcast episode with Daniel Harlow.

Mindscape 349 | Daniel Harlow on What Quantum Gravity Teaches Us About Quantum Mechanics. More real physicists thinking about the foundations of quantum mechanics! #MindscapePodcast

www.preposterousuniverse.com/podcast/2026...

Novo Nordisk Fellowship Potential areas of focus for postdoctoral fellows participating in the MIT-Novo Nordisk Postdoc Program include, but are not limited to, the following: Your complete application should include: In the...

Applications for MIT Novo-Nordisk AI postdoc fellowships are due Apr 15. Focus area lists AI and Biology topics, apply to work on this exciting field with amazing peers! engineering.mit.edu/novo-nordisk

Novo Nordisk Fellowship Potential areas of focus for postdoctoral fellows participating in the MIT-Novo Nordisk Postdoc Program include, but are not limited to, the following: Your complete application should include: In the...

If you're a senior PhD student or recent graduate interested in doing work at the intersection of AI and microbial genomics and/or microbiomes, please feel free to reach out to discuss the possibility of applying together for an MIT Novo Nordisk Fellowship engineering.mit.edu/novo-nordisk

We made FLIP2, a protein fitness benchmark spanning seven new datasets, including enzymes, protein-protein interactions, and light-sensitive proteins, as well as splits that measure generalization relevant to real-world protein engineering campaigns.

The Logic of Catastrophe Proliferation, launch-on-warning, and AI raise the risk of nuclear war far more than you think. This is what we must do to mitigate the risk.

The Logic of Catastrophe open.substack.com/pub/clairebe... Nuclear war isn't inevitable, but if we don't mitigate these risks, it approaches it. None of them will be fixed by optimism, fatalism, or denial. It will only be fixed if citizens get serious about this.

We used to think that the benefit of GLP-1 drugs (like Ozempic) was dependent on weight loss.
Now we know so many health benefits have little to do with that!
Today's report: www.sciencedirect.com/science/arti...

Opportunity in chemical development at AstraZeneca (Dublin Ireland) closing: 27-Jan-2026 #SynChem #EUChemJobs #ChemJobs #chemsky 🧪
astrazeneca.eightfold.ai/careers/job/...

In remembrance of Peer Bork  | EMBL EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.

very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...

I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!

@ppfideas.bsky.social come do some live events in New York this year. We’d love to see you in person

Embedded Systems Engineer / Oxide

Oxide is hiring in the embedded space. If you enjoy baffling choices by hardware vendors and debugging performance issues come join me.

oxide.computer/careers/sw-e...

Loved this pair of episodes. I was laughing at Chis’ unexpected jumps into accent.

Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.

www.cam.ac.uk/jobs/faculty...

BoltzGen now published and available as MIT licensed software

Epic: are we production yet · Issue #63 · quarto-dev/quarto-markdown We need to check against many large sites to get a good sense for the impact of this new syntax in practice. autogenerated qmd quartodoc-generated sites (tbd meet with @machow) sites quarto.org Shi...

Quarto friends! I need your help:

We are implementing a new QMD parser in Quarto. It will be super nice. But it's a big change, and we want to minimize the impact.

1. Can you share a link to your Quarto project at github.com/quarto-dev/q...
2. repost this and let your Quarto friends know too?

Staff Scientist About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Is enhancer-driven gene regulation all wrapped up? - Nature Reviews Genetics In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.

Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...

This is a cartogram depicting the share of land associated with various purposes in the United States. From https://www.bloomberg.com/graphics/2018-us-land-use/#xj4y7vzkg

Below is a clever visualization of the distribution of how land is used in the US. Cows roam over a lot of land!

But this is not a map - for example, the 100 largest landowning families aren't confined to Florida.

What if the Moon were made entirely of electrons? YouTube video by xkcd's What If?

What if the Moon were made entirely of electrons?

Watch the latest What If? video collaboration with @minuteearth.bsky.social!

youtu.be/DiWFXv9N0Vs

Looking forward to discussing INDIGNITY with David Runciman @ppfideas.bsky.social at @waterstones.bsky.social in Cambridge THIS Wednesday! And I hope to see many of you there 🤩😍!
For tickets: t.co/WY5iWDIUZ1

Into natural product biosynthesis & tailoring enzymes? Frustrated by the lack of a dedicated resource to explore their functions? Tired of endless literature searches for reaction info? Meet the MITE database, freely available at mite.bioinformatics.nl. Preprint: doi.org/10.26434/che... (1/8)

The Mask of Sorrow is a monument located on a hill above Magadan, Russia, commemorating the many prisoners who suffered and died in the Gulag prison camps in the Kolyma region of the Soviet Union during the 1930s, 1940s, and 1950s.

The anti-inflammatory power of semaglutide (Ozempic) seen by its normalization to healthy of a 72 protein signature tied to MASH liver disease
nature.com/articles/s41...

Software history nerds don't miss Casey Muratori's long-ass talk tracing the origins of OOP

www.youtube.com/clip/Ugkx9Di...

‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes Covering: 2015 to 2024 Mass spectrometry (MS)-based methods have been implemented extensively for enzyme engineering due to their label-free nature, making them suitable for screening a wide range of…

🔓Read a #OpenAccess review by @drlaurasanchez.bsky.social‬ et al. from @ucsantacruz.bsky.social‬ in our MS Metabolomics themed collection covering mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes #secmet #natprod

Bioconductor and ggplot2 4.0.0: What’s Changing and How to Prepare – Bioconductor community blog Preparing for the upcoming update - key changes, potential breakages, and what developers and users can do

ggplot2 4.0.0 is coming soon, and is moving some of the internals from S3 to the new S7 OOP system. This is worth a read if you're developing packages with ggplot2 (bioconductor or otherwise) blog.bioconductor.org/posts/2025-0... #Rstats

Beautiful. I really like the speed changes as emphasis

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...