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Posts by Mark Toshner

You will not find a clearer thinker and good human being to boot. Medical leadership is painfully difficult and unfortunately full of mediocrity at an important time for the profession. Vote for someone better! bsky.app/profile/drlk...

1 month ago 4 2 1 0

An excellent candidate IMO, careful, thoughtful, and passionate about training enough high quality doctors.

2 months ago 4 3 0 0
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Voting opens today for @rcphysicians.bsky.social elections.

I am standing for Vice President for Education and Training.

It's the first elections where Members will also be able to vote. Please encourage all eligible to exercise their franchise.

More about me here:

tinyurl.com/22j7nypk

1 month ago 5 3 0 3
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The Blue Journal thanks Eckart De Bie, MD, MPhil, for his contribution to the January issue

Inflammation and Obesity Correlate in Pulmonary Hypertension but Associate with Diverging Outcomes
@mark-toshner.bsky.social

academic.oup.com/ajrccm/artic...

2 months ago 7 3 0 0
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Marc Humbert : Pulmonary Arterial Hypertension, The Battle of a Committed Doctor · Inserm Inserm Grand Prize winner, lung specialist and researcher Marc Humbert has devoted his career to deciphering the mechanisms of pulmonary arterial hypertension. From disease characterization to the cre...

Every once in a while awards committees get it right! If there is a more deserving person out there of this than Marc Humbert, I don’t know them!

eur03.safelinks.protection.outlook.com?url=https%3A...

4 months ago 1 0 0 0

Vaccine-related fevers?…

6 months ago 1 1 0 0
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Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

The @washingtonpost.com story on Tylenol & autism leaves out a MAJOR 2.5M sibling-controlled study of children in Denmark, which "found no evidence that acetaminophen use during pregnancy was associated with children’s risk of autism, ADHD or intellectual disability." jamanetwork.com/journals/jam...

7 months ago 5044 2213 147 113
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Pulmonary Hypertension Global Patient Survey: A Call to Action 2025 - PubMed Pulmonary Hypertension Global Patient Survey: A Call to Action 2025

After our mammoth international patient engagement work- some actions for the global community to consider pubmed.ncbi.nlm.nih.gov/40662200/

9 months ago 1 0 0 0
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U.S. measles cases reach 33-year record high as outbreaks spread Johns Hopkins University data reflects the public health reversal in defeating the vaccine-preventable disease since measles was officially eliminated from the U.S. in 2000.

The United States has recorded its highest annual measles cases in 33 years. The milestone marks a public health reversal in defeating a highly contagious, vaccine-preventable disease as the anti-vaccine movement gains strength.

9 months ago 7288 3111 700 456
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Patients are generally positive about changing how they are cared for long term but models will need to be mixed methods if they are to be inclusive

9 months ago 1 0 0 0

4) around 1/3 using smartwatches
Just as important though is that consistently 20%+ don’t want care to involve decentralised techniques

9 months ago 0 0 1 0

2) 80% are positive about care delivered remotely with technology
3)48% are already monitoring their own health regularly in community (1/3 using apps)

9 months ago 3 0 2 0

Few things to chew about modes of care first- I expect they are common across most rare diseases.

1) patient travel hundreds of km for hours, usual in their own car to get to appointments. 45% leave feeling the consultation does not reflect how they feel

9 months ago 3 1 1 0
https://doi.org/10.1183/23120541.00297-2025

First ever international survey of patients with pulmonary hypertension. Wonderful collaborative work. Lots of important and useful insights. t.co/XTvpbS4g8Y

9 months ago 4 1 1 0

@mark-toshner.bsky.social

10 months ago 1 1 0 0

My excellent student winning the best type of award. One for actually remembering the patient in amongst our research! bsky.app/profile/camb...

10 months ago 3 1 0 0
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AND FINAL CONGRATULATIONS to @cam.ac.uk MPhil student Vidisha Handoo, whose poster was voted the best of those on display at last week's Cambridge #PPI Showcase day @angliaruskin.bsky.social @cuh.nhs.uk Thanks to ALL our presenters & poster submissions, you were all great! 3/3

10 months ago 5 1 1 1
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For balance. The next day!

10 months ago 0 0 0 0
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Glasgow. Where the people are funniest because the weather is no joke. Good to be home!

10 months ago 7 0 2 0
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Mental-health lessons in schools sound like a great idea. The trouble is, they don’t work | Lucy Foulkes All-class therapy sessions don’t help, and may even make matters worse. The evidence shows we need different solutions, says Dr Lucy Foulkes, an academic psychologist at Oxford University

I’m in the Guardian today, arguing that we should stop them all-class mental health lessons in schools

I've thought very carefully about ‘going public’ with this, because it's a sensitive argument to make, especially in the face of so many young people struggling.

(cont 🧵)

tinyurl.com/vun92cz7

11 months ago 189 95 12 22
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Lactobacillus Restructures the Micro/Mycobiome to Combat Inflammation-Mediated Right Ventricular Dysfunction in Pulmonary Arterial Hypertension | Circulation: Heart Failure BACKGROUND: Inflammation suppresses right ventricular (RV) function in pulmonary arterial hypertension (PAH). In particular, we showed GP130 (glycoprotein-130) signaling promotes pathological microtub...

www.ahajournals.org/doi/10.1161/.... Our most recent work attacking RV failure! @mark-toshner.bsky.social @ahascience.bsky.social @ahajournals.bsky.social

11 months ago 2 5 0 0

No idea the latest drama but ‘turning out to be’ seems to be a temporally polite way of phrasing this…

11 months ago 4 0 0 0

That joyous moment when you get rid of the 🐵 on your back, AKA submitting that 27 page rebuttal after 9 months of revisions… 🎉 images.squarespace-cdn.com/content/v1/5...

11 months ago 0 0 0 0
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⭐️Meet the speaker⭐️

We’re delighted to have @mark-toshner.bsky.social joining #DDDS2025, who will be speaking on 'How to define or prove disease modification'.

11 months ago 1 1 1 0

I think most senior doctors in UK in positions of importance/power have just turned away rather than consider how terribly demoralised the trainees are by the current awful system.

1 year ago 2 0 0 0

The drugs is coming downstream btw!

1 year ago 1 0 0 0

Among other things coffee, bananas, cars that can turn, computers, drugs and decent humanity about to run into supply problems…

1 year ago 1 0 1 0
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Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death | NEJM Sotatercept improves exercise capacity and delays the time to clinical worsening in patients with World Health Organization (WHO) functional class II or III pulmonary arterial hypertension. The eff...

Quite a stunning result this. Sotatercept in severe pulmonary arterial hypertension www.nejm.org/doi/full/10....

1 year ago 1 0 0 0

‘My dad is so cringe’. I’ve reached peak parenting

1 year ago 3 0 0 0

Honestly. They absolutely don’t fund risky stuff. They say they want world changing research but they fund work that is usually safe as houses.

1 year ago 4 1 3 0