The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky

i-Base graphic. The main text in red and dark blue, on a light blue blue background, reads: CROI 2025. Tecovirimat data confirmed. No benefit against mpox. Below, in white on a burnt orange background, text reads, San Francisco, California. 9th to 12th March. On top of this is a faint image of the Golden Gate Bridge. In the top left corner is a URL: I hyphen base dot info. In the top right corner is a box made of blue, yellow and red blocks. White text on it reads, HTB news. 2025.

#Tecovirimat has no benefit against #mpox:

i-base.info/htb/50631

Full results from the STOMP study have now been presented. They show that tecovirimat didn’t help treat or reduce pain from mpox.

#CROI2025 #IDsky #HIVsky #Medsky #DRC #GlobalHealth #GlobalCrisis

#IDsky
Wow. Increased major cardiovascular event with abacavir compared to TDF and TAF up to 40-50%. Absolute numbers low but still.
Does this make ABC obsolete? Do we switch everyone off based on this if they have alternative options?

academic.oup.com/ofid/advance...

Self administration of OPAT is the winner in terms of environmental impact.

Of course, oral antibiotics, if an option, would beat all IV options hands down!

#IDSky #ClinMicro #AMR
@jac-amr.bsky.social

academic.oup.com/jacamr/artic...

DOR/ISL studies #CROI2025

I don’t understand why HBV vaccination AND confirmed protection wasn’t an inclusion criteria

2 unnecessary acute HBV cases

#IDsky #HIVsky

New research - Early antiviral treatment with tenofovir alafenamide to prevent serious clinical adverse events in adults with chronic hepatitis B and moderate or high viraemia (ATTENTION): interim results from a randomised controlled trial

tinyurl.com/4cvdy6h2

#LiverSky #IDSky #MedSky #HepSky

Visual abstract showing tMPS was diagnostic in 71.4% vs 34.7% for Sanger sequencing

Detection of fungal pathogens by a histomolecular approach using targeted-massive parallel sequencing on formalin-fixed tissues: a retrospective study

tMPS performed much better than Sanger sequencing of amplicons using panfungal PCR primers

www.clinicalmicrobiologyandinfection.com/article/S119...

Spread of Antifungal-Resistant <em>Trichophyton indotineae</em>, United Kingdom, 2017–2024 Spread of Antifungal-Resistant <em>Trichophyton indotineae</em>, United Kingdom, 2017–2024

Spread of Antifungal-Resistant Trichophyton indotineae, United Kingdom, 2017–2024

@aabdolra.bsky.social et al

T indotineae (which is terbinafine resistant in 3/4 cases) has rapidly spread thru the UK, now comprising 38% of dermatophytes at the national reference lab

wwwnc.cdc.gov/eid/article/...

Neurocysticercosis school outbreak in Belgium Human cysticercosis results from ingesting microscopic Taenia solium eggs shed by a tapeworm carrier, forming cystic larvae (ie, cysticerci) in tissues. These larvae normally encyst in the pig, the natural intermediate host. Upon consumption by humans, they develop into a new intestinal tapeworm. Affecting the human brain, neurocysticercosis is responsible for a third of epilepsy cases in endemic tropical and subtropical regions.1,2

Neurocysticercosis school outbreak in Belgium 😮🪱🇧🇪

www.thelancet.com/journals/lan...

Interim Results from STOMP Study of SIGA’s Tecovirimat in Treatment of Mpox Announced Interim analysis shows that tecovirimat did not improve time to lesion resolution compared to placebo in adults with mild to moderate clade II mpoxStudy...

STOMP Study Interim analysis:

- TPOXX (tecovirimat) showed no improvement in lesion resolution time vs placebo in adults with mild-to-moderate clade II mpox
- Enrollment stopped in all study arms
- Strong safety profile
- Efficacy in severe cases not assessed
www.globenewswire.com/news-release...

Piperacillin/tazobactam vs. cefepime or carbapenems for the treatment of bloodstream infections due to bacteria producing chromosomal AmpC beta-lactamase: a systematic review and meta-analysis - Infec... Background The best treatment for bloodstream infections (BSI) due to chromosomal AmpC (c-AmpC) producing Enterobacterales is not clearly defined. Objectives To describe the clinical and microbiologic...

🆕️🔥Systematic review & meta-analysis
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...

💬 Words have power! Choose them with care:

✅ "People living with HIV"
❌ "Infected people"

✅ "HIV acquisition"
❌ "Infection"

✅ "A person who has acquired HIV"
❌ "Spreading HIV"

🌐 Join us in using inclusive language on #WorldAIDSDay & every day: www.iasociety.org/language-mat...

A case of penicillin-resistant group B Streptococcus isolated from a patient in the UK AbstractObjectives. In England, group B streptococci (GBS; Streptococcus agalactiae) are considered universally susceptible to penicillin. Reports from Afr

academic.oup.com/jac/advance-...
Just published the first case of penicillin-resistant group B Streptococcus isolated from a patient in the UK - though of note this was from 2016 and we have not seen any further penicillin resistance since - however a salient reminder that #AMR is ever a possibility

Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection Abstract. Antibiotic prophylaxis is often recommended for close contacts of index cases of invasive Streptococcus pyogenes infections. Using MarketScan dat

🆕️⚡️⚡️ #CIDJournal
Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection
No difference in infection rates between those who received and those who did not receive antibiotic #idsky #medsky
academic.oup.com/cid/advance-...

Insights into durability against resistance from the antibiotic nitrofurantoin - npj Antimicrobials and Resistance npj Antimicrobials and Resistance - Insights into durability against resistance from the antibiotic nitrofurantoin

Nitrofurantoin has shown exceptional durability against resistance over 70y of use
🆕️✨️What makes nitrofurantoin robust against resistance evolution,in spite of prolonged & extensive usage against UTIs? #idsky #medsky #utisky
www.nature.com/articles/s44...

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

🔥BALANCE RCT🔥
74 hospitals in 7 countries
3,608 patients
A 7-day course of antibiotics for hospitalized patients with bloodstream infections was non inferior to 14d within a 4% prespecified margin for mortality at 90 days #idsky
www.nejm.org/doi/full/10....

Oropouche Virus: A Rising Threat in the Western Hemisphere | Annals of Internal Medicine

🆕️⚡️⚡️Oropouche Virus: A Rising Threat in the Western Hemisphere #idsky
www.acpjournals.org/doi/10.7326/...

Resistance profiles of carbapenemase-producing Enterobacterales in a large centre in England: are we already losing cefiderocol? AbstractBackground. Carbapenemase-producing Enterobacterales (CPE) pose difficult therapeutic challenges. We aimed to characterize antimicrobial resistance

New paper from my colleagues at UCLH

Nearly 70% (!!!) resistance to Cefiderocol in NDM positive bacteria.

Cefiderocol...we hardly knew ye...

Perfect timing for World Antimicrobial Awareness Week #waaw24 #IDSky

academic.oup.com/jac/advance-...

UK guidelines for the investigation and management of eosinophilia in returning travellers and migrants Eosinophilia is a common finding in returning travellers, migrants and other travelling groups. In this setting it often indicates an underlying helminth infection. Infections associated with eosinoph...

New: UK guidelines for the investigation and management of eosinophilia in returning travellers and migrants.

#IDsky #microsky @drneilstone.bsky.social

www.journalofinfection.com/article/S016...

🔥SNAP passed 3500🔥
Writing papers:
Cefazolin (MSSA) and penicillin (PSSA) vs (flu)clox
Recruiting:
Adj clinda vs not (all)
Adj cefazolin vs not (MRSA)
Oral switch vs IV (all)
Cefazolin +/- Erta/Placebo (MSSA)
Dapto vs Vanco (MRSA)
Coming "soon":
Rifampin vs. none for PVIE (all)
Ref: Dr.Lee #idsky

First evidence of resistance to lifesaving antimalarial drug in African children with severe malaria

Colin Sutherland says findings raise concerns of pattern of resistant #malaria parasites.🦟 #PublicHealth

www.lshtm.ac.uk/newsevents/n...