⭐ NAR Breakthrough! ⭐

A community-driven collection uniting 52 phages, 74 Klebsiella isolates, and extensive genomic + phenotypic data — all freely available at klebphacol.org.
🧬 Learn more: doi.org/10.1093/nar/...
@fnobrega.bsky.social @danielarothschild.bsky.social #antimicrobialresistance

And so much more, go check it out!

The data is also available for exploration at www.klebphacol.org, where you can also submit requests to obtain the collection (www.klebphacol.org/request-form).

Again, huge thanks to everyone involved 👏🏻

🧵5/5

We also include IBD-relevant phages targeting K. pneumoniae
ST323! One of which was a novel temperate phage, now under the ICTV-accepted Felixviridae family, with experimental validation for its temperate lifestyle.

🧵4/5

Most of the phages don’t target capsule, contributing to their broader host-range

🧵3/5

In this work we present a collection of Klebsiella phages and strains openly accessible to the research community with the aim of informing phage therapy and advancing broader biological insights!

🧵2/5

Thrilled to share the core of my PhD work, now published in NAR!

This project was a true collaborative effort across multiple teams, and it was a joy to bring it to life.

Huge thanks to everyone involved, and especially to @fnobrega.bsky.social for the incredible support and guidance 🙏🏻

🧵1/5

History of Phage Therapy — ThePhageCollectionProject Phage therapy is not a recent discovery; it dates back to the early 20th century, with two scientists making impactful discoveries within two years of each other. But research priorities shifted towar...

🔬 To celebrate World Phage Week, this month's issue of the Phage Collection Blog, written by Hana, explores the history of phage therapy. Thanks to @danielarothschild.bsky.social for providing the cover image, showcasing phage ROTH78.

#WorldPhageWeek

www.phage-collection.org/blog/history...

Contact 1 — KlebPhaCol

📣We are preparing for the next KlebPhaCol shipment - coming in June 2025!

Please submit any requests before the 30th of May to be included in this shipment
👇
www.klebphacol.org/request-form

Arms Race between Phages and Bacteria — ThePhageCollectionProject Since bacteriophages were first identified in the early 1900s, scientists have described an ongoing ‘arms race’ between bacteria and phages. They don’t have nuclear weapons like humans, so what is the...

🔬For this month’s issue of the Phage Collection Project Blog Hana has discussed the arms race that exists between bacteria and phages. Make sure to go and check it out! Thanks to @danielarothschild.bsky.social for the cover photo of ROTH47!

www.phage-collection.org/blog/arms-ra...

Last week I had the great opportunity to present my @klebphacol.bsky.social PhD research at VoM UK!

Thank you Claire!😊🤞🏻

Incredibly proud and happy to share the preprint of the biggest bulk of my PhD project so far!

Lots of thank yous due - big shoutout to my supervisor @fnobrega.bsky.social for the support and for conceiving this wonderful resource, and to all the colleagues involved✨🙌

Please check it out😊👇🏻

Phage-plasmid hybrids are found throughout diverse environments and encode niche-specific functional traits Phage-plasmids are unique mobile genetic elements that function as plasmids and temperate phages. While it has been observed that such elements often encode antibiotic resistance genes and defense sys...

If you are interested in P-Ps, also check this fantastic novel work

www.biorxiv.org/content/10.1...

Figure 1

We summarise P-P characteristics, replication cycles, their roles in HGT and more!

Characteristics of phage-plasmids and their impact on microbial communities Abstract. Bacteria host various foreign genetic elements, most notably plasmids and bacteriophages (or phages). Historically, these two classes were seen as separate, but recent research has shown con...

Excited to share this new publication where we review the current stand of Phage-Plasmids (P-Ps), check it out!

@fnobrega.bsky.social

portlandpress.com/essaysbioche...