We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

Nature Conferences presents "Cracking the Code: Nucleic Acid Medicines Coming of Age" from December 8-10, 2025, at Harvard Campus, Boston, MA, USA. The image prompts viewers to swipe to meet some of the experts presenting.

Portrait of Mano Manoharan, Senior Vice President at Alnylam Pharmaceuticals. The background includes a DNA strand graphic.

A portrait of Arthur Krieg, founder of Zola Therapeutics. The background is navy with abstract scientific graphics.

Headshot of Anne Pyle, professor at Yale University. The background is dark blue with abstract graphics.

Join researchers, biotech innovators, and pharma leaders in Boston this December for Cracking the Code: Nucleic Acid Medicines Coming of Age. Explore how advances in RNA and DNA therapeutics are shaping the next generation of medicine. go.nature.com/4nbCcaK 🧬#STEMconference

Nature Conferences. Cracking the Code: Nucleic Acid Medicines Coming of Age. December 8 - 10, Boston, MA, United States. Organized by Alnylam, Ionis, HSCI, Boston Children’s Hospital, and Nature Portfolio

Speakers include: Anna Pyle (Yale),’Arthur Krieg (Zola Therapeutics), Mano Manoharan (Alnylam), Grace Chen (Yale), Howard Chang (Stanford), Maria Barna (Stanford) - picture shows their portraits.

Join us for the 3rd Nature Conference on Nucleic Acid Medicines in Boston (Dec 8-10) with an amazing lineup of speakers. 4 weeks left 4 early bird registration! natureconferences.streamgo.live/cracking-the...
@natureportfolio.nature.com @nature.com @natbiotech.nature.com @natrevdrugdiscov.nature.com

A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.

Enables ‘watching’ of RNP assemblies inside living cells

Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...

Excited for day two of #FCQC2025 for a great set of talks about all things quality control!

Proud to represent @naturecellbiology.bsky.social as senior editor; come find me to chat! Keep an eye out for other editors including my brilliant colleague @sshadan.bsky.social senior editor from Nature

Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...

New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social

www.nature.com/articles/s41...

Cleaning up space: how satellites and telescopes can live together Satellites connect people around the world but they also interfere with astronomers’ views of the cosmos. There are ways to reduce these tensions.

Editorial: The skies are a shared resource. We spend public money and push the limits of technology to look into the depths of the Universe - but now often see private communication satellites instead. Solutions exist, but regulation and enforcement are lacking. www.nature.com/articles/d41...

Overlapping nuclear import and export paths unveiled by two-colour MINFLUX - Nature High spatiotemporal precision tracking using 3D MINFLUX shows that nuclear import and export occur in overlapping regions of the central pore, providing insight into transport across the nuclear pore complex.

Nature research paper: Overlapping nuclear import and export paths unveiled by two-colour MINFLUX

https://go.nature.com/4iRwmJm

Hey all! The RNA Society meeting in San Diego features a new session for sharing results on new ways to bring RNA into the curriculum. Get your abstracts in ASAP!

Very interesting 20 minute documentary about toxic culture and power abuse at some Max Planck Institutes in Germany.

I think it's important to reach out to your own community and explain what the funding cuts mean in practice.

In this time of chaos - something good! We are excited to share our final (or near final) speaker list for the 3rd UCSF Full Circle Symposium 4/3-4/4 to highlight Native biologists! Please share the word and register to attend the webinar in person! More info: qbi.ucsf.edu/full-circle-...

UNITED24 - The initiative of the President of Ukraine UNITED24 was launched by the President of Ukraine Volodymyr Zelenskyy as the main venue for collecting charitable donations in support of Ukraine. Funds will be transferred to the official accounts of...

If you’re still dumbfounded, I invite you to join me in donating.

Let’s send a message of hope to Ukraine in these difficult times.

u24.gov.ua

#Argonautes2025 update ... it will happen this August (27-30) @imgprague.bsky.social. Our ITs are finishing and testing the website, the registration will open on March 1st. More info will be provided later (once all speakers reply to my e-mail, just saying, not pushing 😁). Poster announcement:

100 years of Australopithecus On 7 February 1925, Nature published a curious paper on a ‘missing link’ – the fossil of a form intermediate between apes and humans.

On 7 February 1925, Nature published a curious paper on a ‘missing link’. Check out the palaeoanthropology paper collection to mark the 100 year anniversary of the publication of Australopithecus africanus www.nature.com/collections/... and our editorial www.nature.com/articles/d41...

Henry Gee: The Decline and Fall of the Human Empire - The Book Hive We are excited to announce the first in a new series of events at Aylsham Town Hall! Join us as Nature magazine editor and Royal Society Science Book Prize winner Henry Gee explores the future of […]

UK launch of THE DECLINE AND FALL OF THE HUMAN EMPIRE: www.thebookhive.co.uk/event/henry-...

Reconstitution of synaptic junctions orchestrated by teneurin-latrophilin complexes Synapses are organized by trans-synaptic adhesion molecules that coordinate assembly of pre- and postsynaptic specializations, which, in turn, are composed of scaffolding proteins forming liquid-liqui...

Presynaptic and postsynaptic phase-separated liquids stay separate (“demonstrating a high degree of specificity”) even without membranes (!) and are tethered together with teneurin and latrophilin🤔🧐🤨 #synapses

www.science.org/doi/abs/10.1...

Hi, new followers! 👋
I'm a Senior Editor @natrevmcb.bsky.social, working on articles across most of cell biology—from cell migration & death to plant & structural biology (and beyond!). Based in Berlin, I share my home office with very cuddly cats 🐈‍⬛🐈

Follow along if you're curious about cell bio!

This is figure 3, which shows the crystal structures of 3FTx-binding proteins closely matched those of the design models.

A study in Nature used deep learning methods to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible antivenom treatments. https://go.nature.com/4aDxmxK 🧪

Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196 Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.

www.nature.com/naturecareer...

It seems being called the „Steve Jobs of something“ isn’t usually a good sign?

Feeling bad for the 60ish people in this lab…

New Article: "Structural mechanism underlying PHO1;H1-mediated phosphate transport in Arabidopsis" rdcu.be/d62pA

Phosphate transporter PHO1: cryo-EM, biochemical & physiological analysis. Molecular and regulatory mechanism of transport mediated by the SPX–EXS family. #PlantScience

About time!

Wow. This is the first neat paper of 2025! From a baby plate of HEK cells and a uL column

Structural basis for the conformational protection of nitrogenase from O2 - Nature Cryo-electron microscopy of Azotobacter vinelandii FeSII–nitrogenase reveals a core complex of molybdenum–iron proteins (MoFePs), iron proteins (FePs) and FeSII, in which FeSII mediates interactions with MoFeP and FeP to position their FeS clusters in catalytically inactive but O2-protected states.

Nature research paper: Structural basis for the conformational protection of nitrogenase from O2

https://go.nature.com/4aiD344

Conformational protection of molybdenum nitrogenase by Shethna protein II - Nature A small ferredoxin (Shethna protein II) of Azotobacter vinelandii can provide protection from O2 stress that may be crucial for the maintenance of recombinant nitrogenase in food crops.

Nature research paper: Conformational protection of molybdenum nitrogenase by Shethna protein II

https://go.nature.com/3DVICZZ

Has Bluesky replaced X for scientists? Take Nature’s poll The research community has flocked to the social-media platform Bluesky. Tell us about your experience.

Nature is keen to find out how scientists are using Bluesky and whether it has become their go-to soc media platform. Do you use Bluesky? Has it replaced X for you? Tell us about it: www.nature.com/articles/d41...

Hey @mdc-berlin.bsky.social 👀

RNA control of reverse transcription in a diversity-generating retroelement
www.nature.com/articles/s41...

Self-organized patterning of crocodile head scales by compressive folding - Nature Crocodile head scales self-organize through purely mechanical compressive skin folding rather than a patterning process controlled by gene interactions.

🎉 We're excited to share our new research in @nature.com ! We reveal that crocodile head scales self-organize through compressive folding of the skin - a mechanical twist on their development & evolution!
Please read & share 🐊🔬 @genevunige.bsky.social