H1 is the core nucleosome? Who would have thought 🤭

Cas9 enrichment does not work properly anymore with the new flow cells. Free DNA in the flow cell clogs the pores (even without the motor protein attached )

pmc.ncbi.nlm.nih.gov/articles/PMC...

For pcr free it can be easily adapted I guess

Happy 30th birthday to this paper published March 22, 1996, one of the studies that moved chromatin biology from correlation toward mechanism. Brownell et al. linked a transcription-associated Tetrahymena HAT to yeast Gcn5p, providing a biochemical link for chromatin modification to gene activation.

How do the H2A.Z histone variant and its dedicated chromatin remodeller SRCAP regulate gene expression ?
Beautiful work from @armelletollenaere.bsky.social now published @ www.nature.com/articles/s41...

Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar.
Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse.
www.biorxiv.org/content/10.6...

Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...

Structural basis for non-AUG translation regulation by 5MPs www.biorxiv.org/content/10.64898/2025.12...

The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access)
link.springer.com/collections/...

Its out!!!

IN MEMORIAM: A totipotent embryologist: John B. Gurdon
(1933–2025)
By Thoru Pederson
➡️ https://tinyurl.com/gd353471OA

*Photo courtesy of the Cold Spring Harbor Laboratory Archives.

It has not escaped our notice that LLM generate replaceable, non-intuitive statements suggesting a mechanism of dullness and copy paste

Paul Nurse describing the main job of a PI

(From ‘The Thinking Game’, 2024)

General framework for centromere organisation built on a model of the internal stratification of the Earth

Special issue: The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd

There are two big traps that US higher education fell into.

First: the research building boom. Universities realized that by constructing new research buildings, they could raise their indirect cost rate, the percentage of federal grant money that they can claim for overhead.

2/10

I don’t think most people (including academics) realize just how screwed American universities are right now. Yes, the Trump attacks hurt. But the deeper crisis comes from the slow rot of a corporate mindset in university leadership that traded mission for growth. Let’s talk about that.

A 🧵

1/10

a baby in a blue shirt is making a funny face ALT: a baby in a blue shirt is making a funny face

All faculty are junior PIs?

#2. How Germany Is Losing the Battle for the Brightest Minds Germany’s science bureaucracy dreams of luring famous researchers away from Trump’s America. But it mustn’t cost much.

Leider wahr. #DenkIchAnDeutschland

gersemann.substack.com/p/2-how-germ...

UMass Chan leads new $4.4 million study to study melanoma UMass Chan Medical School received a five-year, $4.4 million National Cancer Institute grant to study how transfer RNAs may fuel the spread of melanoma.

UMass Chan Medical School has received a five-year, $4.4M grant to study how transfer RNAs may drive the spread of melanoma: direc.to/nJeJ

Richard I. Gregory, PhD, is collaborating with Beth Israel Deaconess Medical Center and Brown University.

#CancerResearch #melanoma @bidmcreseach.bsky.social

Many thanks to all attendees of the GfG Sympsoium "Epigenetics & Chromatin" for making this conference such a great success! Go to www.gfgenetik.de for more information and fotos. Become a GfG member!

What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!

Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.

Ie: it's not us (Samtools team)! Be warned

Bäm

Please never show this to my mom!

I love the smell of toxische Abgase in the morning

I too have never seen star activity in EcoRI digests.

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