Impact of baseline medications on real-world overall survival in immune checkpoint inhibitor-treated patients with cancer in the RADIOHEAD cohort Medication exposure has the potential to impact anti-tumor immunity through direct and indirect mechanisms that may disrupt ICI efficacy. Stone et al. demonstrate that baseline polypharmacy was associated with worse survival and that opioid and beta-blocker use independently predicted inferior outcomes for patients with cancer receiving ICI treatment.

Online Now: Impact of baseline medications on real-world overall survival in immune checkpoint inhibitor-treated patients with cancer in the RADIOHEAD cohort

Ferroptosis in MASLD: From molecular mechanisms to therapeutic opportunities Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a key driver of liver injury in metabolic dysfunction-associated steatotic liver disease. This review summarizes the molecular mechanisms linking ferroptosis to disease progression and systemic complications, as well as emerging therapeutic strategies targeting iron metabolism, lipid peroxidation, and antioxidant defenses.

Online Now: Ferroptosis in MASLD: From molecular mechanisms to therapeutic opportunities

CD19 CAR-T therapy induces remission in refractory autoimmune hemolytic anemia with ITP and antiphospholipid syndrome This single-patient case report expands the indications in which CD19 CAR-T cell therapy demonstrates unprecedented clinical efficacy, achieving sustained, treatment-free remission. Following B cell abrogation, AIHA is stopped, antiphospholipid antibodies are abrogated, and an underlying ITP is stabilized without any CAR-typical side effects.

Online Now: CD19 CAR-T therapy induces remission in refractory autoimmune hemolytic anemia with ITP and antiphospholipid syndrome

Comparative efficacy of phase 2–3 therapies for non-cirrhotic metabolic dysfunction-associated steatohepatitis: An updated network meta-analysis A network meta-analysis of 64 phase 2–3 trials in non-cirrhotic metabolic-dysfunction-associated steatohepatitis compared biopsy endpoints and liver fat reduction by MRI-PDFF. Metabolic and insulin-sensitizing therapies showed the most consistent efficacy, while biopsy placebo response was 11%–18%, and 35%–70% of participants failed to meet prespecified histologic targets.

Online Now: Comparative efficacy of phase 2–3 therapies for non-cirrhotic metabolic dysfunction-associated steatohepatitis: An updated network meta-analysis

Emerging therapeutic directions for inotropic therapy in heart failure In heart failure with reduced ejection fraction, the fundamental problem is reduced contractility. Guideline-directed medical therapy delays progression but does not target contractility. This review describes traditional and emerging inotropes, their mechanisms of action, and how these mechanisms translate into increased contractility and clinical risks and benefits.

Online Now: Emerging therapeutic directions for inotropic therapy in heart failure

Autism spectrum disorder in China: Clinical practices, challenges, and future Yang et al. review China’s autism spectrum disorder services through a pyramid management-community-maternal and child care-medicine model. Framing ASD care as a public health-embedded tiered system, they analyze integration of hierarchical management, precise service, and parenting education across screening, diagnosis, and intervention, highlighting achievements, challenges, and scalable strategies.

Online Now: Autism spectrum disorder in China: Clinical practices, challenges, and future

Pyramidal signs in Huntington’s disease: An early clinical indicator associated with proximity to disease onset Pyramidal signs are commonly observed in Huntington’s disease but poorly understood. Li et al. show that these signs emerge over a decade before predicted motor symptom onset in HD, yet they do not predict disease progression after symptom manifestation.

Online Now: Pyramidal signs in Huntington’s disease: An early clinical indicator associated with proximity to disease onset

Efficacy of immunotherapy rechallenge in locoregionally advanced nasopharyngeal carcinoma after progression: A real-world analysis He et al. retrospectively analyzed patients with locoregionally advanced nasopharyngeal carcinoma who received immunotherapy and subsequently relapsed. Immunotherapy rechallenge as first-line treatment did not improve survival in the overall cohort but conferred survival benefits in patients with an immunotherapy-free interval >1 year, providing real-world insights to inform individualized treatment decisions.

Online Now: Efficacy of immunotherapy rechallenge in locoregionally advanced nasopharyngeal carcinoma after progression: A real-world analysis

Evaluation of recombinant human prourokinase for acute pulmonary embolism: A phase 2, randomized clinical trial This randomized, phase 2 trial compared recombinant human prourokinase (rhPro-UK) with standard rt-PA for acute pulmonary embolism. RhPro-UK demonstrated comparable efficacy in hemodynamic improvement but was associated with significantly fewer total bleeding events.

Online Now: Evaluation of recombinant human prourokinase for acute pulmonary embolism: A phase 2, randomized clinical trial

Large-scale quantitative metabolomics and mass spectrometry imaging define the metabolic atlas in human acute type A aortic dissection By integrating multi-omics and mass spectrometry imaging, Zhou et al. depicted the first large-scale quantitative and spatial aortic metabolome landscape in human acute type A aortic dissection. They pinpointed tunica media/intima-enriched metabolites that are associated with adverse clinical outcomes and disease progression, providing promising prognostic and therapeutic avenues.

Online Now: Large-scale quantitative metabolomics and mass spectrometry imaging define the metabolic atlas in human acute type A aortic dissection

Long-term outcomes by clinical and molecular risk stratification in patients with medulloblastoma receiving risk-adapted therapy Liu et al. demonstrate that integrating subgroup-specific genetic events with clinical features effectively discriminates medulloblastoma prognoses. They find that radiation dose-response effects vary by risk stratification, underscoring the potential for molecularly informed strategies.

Online Now: Long-term outcomes by clinical and molecular risk stratification in patients with medulloblastoma receiving risk-adapted therapy

Deep multi-omics profiling reveals three molecular subtypes of chronic obstructive pulmonary disease in a unique biomass-exposed Chinese population (Med 7, 101033; April 10, 2026)

Online Now: Deep multi-omics profiling reveals three molecular subtypes of chronic obstructive pulmonary disease in a unique biomass-exposed Chinese population

Mazdutide 9 mg in Chinese adults with a body mass index ≥30 kg/m2 but without diabetes: A phase 2 randomized controlled trial In a phase 2 randomized trial by Ji et al. the dual GCG/GLP-1 receptor agonist mazdutide 9 mg achieved a 24-week placebo-adjusted weight reduction of 15.4%, alongside improvements in multiple cardiometabolic risk factors and a manageable safety profile, supporting its further clinical development for the management of moderate to severe obesity.

Online Now: Mazdutide 9 mg in Chinese adults with a body mass index ≥30 kg/m2 but without diabetes: A phase 2 randomized controlled trial

Women’s perspectives on health service integration for multi-morbidity in pregnancy, childbirth, and postpartum in a high-burden setting A longitudinal study of women and infants in Papua New Guinea found high rates of multiple coexisting health problems, and women favored integrated health care services that prioritized specific health needs. Antenatal and postpartum services in low- and middle-income countries should address multiple simultaneous health needs while incorporating women’s preferences into service planning.

Online Now: Women’s perspectives on health service integration for multi-morbidity in pregnancy, childbirth, and postpartum in a high-burden setting

Anti-CD19 CAR T cell therapy for refractory SLE-ITP Li et al. demonstrate that anti-CD19 CAR T cell therapy provides a safe, effective treatment for refractory SLE-ITP. While all patients achieved clinical response, multi-omics analysis revealed that incomplete clinical recovery in some individuals is driven by persistent bone marrow B cell activation and impaired platelet production pathways despite peripheral B cell depletion.

Online Now: Anti-CD19 CAR T cell therapy for refractory SLE-ITP

Deep multi-omics profiling reveals three molecular subtypes of chronic obstructive pulmonary disease in a unique biomass-exposed Chinese population Wu et al. conduct deep multi-omics profiling on a unique Chinese population of chronic obstructive pulmonary disease by integrating radiomics, metabolomics, microbiomics, and genomics data. They revealed three molecular subtypes, enhancing our understanding of the heterogeneity of chronic obstructive pulmonary disease.

Online Now: Deep multi-omics profiling reveals three molecular subtypes of chronic obstructive pulmonary disease in a unique biomass-exposed Chinese population

T cell exhaustion in bi- and trispecific T cell engager therapy in hematologic malignancies: Mechanisms and implications The review by Muth et al. summarizes current evidence of pre-existing and therapy-induced T cell exhaustion in patients treated with bispecific T cell engagers for hematological malignancies. It discusses underlying biological mechanisms and provides an overview of emerging therapeutic strategies to ameliorate T cell exhaustion to improve the durability and efficacy of these immunotherapies.

Online Now: T cell exhaustion in bi- and trispecific T cell engager therapy in hematologic malignancies: Mechanisms and implications

Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model Zhang et al. show that precise DNA base editing restores hearing in an adult hereditary deafness model, DFNB9, demonstrating a broad therapeutic time window and supporting the safety and translational potential of this strategy for genetic hearing loss.

Online Now: Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model

A machine learning model integrating circulating Temra cell transcriptional profiles to predict immunotherapy efficacy Circulating Temra cells constitute a clonally expanded CD8+ T cell subset correlated with immunotherapy response. Dong et al. developed a machine learning model based on Temra transcriptional profiles to predict treatment outcomes, which was subsequently validated prospectively in a multi-center non-small cell lung cancer cohort via bulk RNA sequencing.

Online Now: A machine learning model integrating circulating Temra cell transcriptional profiles to predict immunotherapy efficacy

Single-cell profiling of immune reset in patients with refractory generalized myasthenia gravis receiving autologous CD19/BCMA CAR-T cell therapy In this phase 1 trial, Ruan et al. demonstrate that CD19/BCMA dual-targeting CAR-T cells are safe and effective in refractory generalized myasthenia gravis without lymphodepletion, leading to systemic immune reset via B cell lineage reconstitution.

Online Now: Single-cell profiling of immune reset in patients with refractory generalized myasthenia gravis receiving autologous CD19/BCMA CAR-T cell therapy

Health care utilization and self-reported health status among US cancer survivors by rurality and area deprivation Lee et al. found that cancer survivors in rural and the most deprived areas were generally less likely to visit health care providers and more likely to have fair or poor health status. In adjusted models, many of these associations persisted.

Online Now: Health care utilization and self-reported health status among US cancer survivors by rurality and area deprivation

Becotatug vedotin, MRG003, in previously treated recurrent or metastatic nasopharyngeal carcinoma: A multicenter, single-arm, phase IIa trial In a phase IIa trial, Han et al. report that the EGFR-targeting antibody-drug conjugate MRG003 shows promising efficacy with a manageable safety profile in patients with platinum- and immunotherapy-refractory recurrent/metastatic nasopharyngeal carcinoma, offering a potential new therapeutic strategy for this population with limited options.

Online Now: Becotatug vedotin, MRG003, in previously treated recurrent or metastatic nasopharyngeal carcinoma: A multicenter, single-arm, phase IIa trial

Current state of CAR-T cell therapies for solid tumors Chimeric antigen receptor (CAR)-T cell therapy is effective in blood cancers but faces obstacles in solid tumors, including antigen heterogeneity and an immunosuppressive tumor microenvironment. This review summarizes key preclinical and clinical findings and highlights emerging strategies, including innovative CAR designs, non-conventional CAR-based therapies, and in vivo engineering, to overcome these obstacles.

Online Now: Current state of CAR-T cell therapies for solid tumors

COPD reshapes the tumor microenvironment of NSCLC and enhances anti-PD-1 therapy response Chen et al. show that COPD reshapes the lung epithelium in NSCLC, expanding CXCL14+ basal-like tumor cells. These cells recruit macrophages producing CXCL9 through the CXCL14-CXCR4 axis, creating an immune-permissive niche that enhances the anti-PD-1 inhibitor response.

Online Now: COPD reshapes the tumor microenvironment of NSCLC and enhances anti-PD-1 therapy response

Patient-reported outcomes from a phase 2 PLATINUM trial of nivolumab combination therapy sparing concurrent cisplatin in nasopharyngeal carcinoma Xu et al. conduct a full analysis of patient-reported outcomes from the phase 2 PLATINUM trial of nivolumab combination therapy sparing concurrent cisplatin in nasopharyngeal carcinoma. The results support social reintegration as a practical composite indicator of favorable patient-reported outcomes. Interventions targeting speech, swallowing, and decreased appetite might promote better recovery.

Online Now: Patient-reported outcomes from a phase 2 PLATINUM trial of nivolumab combination therapy sparing concurrent cisplatin in nasopharyngeal carcinoma

Toward precision immunotherapy: In vivo gene editing of T, NK, and myeloid cells This review outlines how emerging in vivo immune engineering strategies—encompassing viral and non-viral vectors—can reprogram immune cells directly within the body to restore immunosurveillance. By enhancing immune cell persistence, specificity, and function in situ, these approaches have the potential to bypass logistical barriers to ex vivo cell manufacturing.

Online Now: Toward precision immunotherapy: In vivo gene editing of T, NK, and myeloid cells

Analysis of biomarkers in the Human Phenotype Project using disease models from UK Biobank Pellow et al. combine predictive models from the UKBB with the deep multi-omic Human Phenotype Project cohort to identify biomarkers for predicted disease. In addition to recapitulating many known disease biomarkers, they identify new biomarkers, sex-specific biomarkers, and biomarkers prevalent across a wide range of diseases.

Online Now: Analysis of biomarkers in the Human Phenotype Project using disease models from UK Biobank

The diversity of emerging tick-borne viruses globally: From discoveries to zoonotic risk assessment By compiling 1990–2024 data on emerging tick-borne viruses, Zhang et al. characterized their host range, distribution, and virus-host interactions; constructed a zoonotic risk model; and validated three novel human pathogens via clinical samples to inform global surveillance.

Online Now: The diversity of emerging tick-borne viruses globally: From discoveries to zoonotic risk assessment

Adjunctive intravenous tirofiban plus methylprednisolone for acute ischemic stroke: A pooled analysis of the RESCUE BT and MARVEL trials In this pooled individual patient data analysis of the RESCUE BT and MARVEL trials, Ye et al. showed that combined tirofiban and methylprednisolone as an adjunct to endovascular thrombectomy (EVT) for acute large-vessel occlusion stroke improved functional outcomes without major safety concerns compared with EVT alone.

Online Now: Adjunctive intravenous tirofiban plus methylprednisolone for acute ischemic stroke: A pooled analysis of the RESCUE BT and MARVEL trials

Incidence and spectrum of immune-related adverse events in nasopharyngeal carcinoma patients treated with immune checkpoint inhibitors This meta-analysis of 27 trials (2,459 nasopharyngeal carcinoma patients) finds 69.1% all-grade and 8.1% grade ≥3 immune-related adverse events with immune checkpoint inhibitors, with hypothyroidism and rash most common. It offers NPC-specific safety data to guide clinical monitoring of immune checkpoint inhibitors.

Online Now: Incidence and spectrum of immune-related adverse events in nasopharyngeal carcinoma patients treated with immune checkpoint inhibitors