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Posts by Michael Hoffman

Oh, so you're saying three things can't be true?

(Please don't block me)

15 hours ago 1 0 0 0

We've seen this time and time again—it's easier to make a line over something that is relatively inconsequential yet highly obvious than something that is incredibly important and unclear.

16 hours ago 4 0 0 0

Whether democracy is undermined is subject to debate. Making health care better is a hard problem.

But a gravy plane for Mr. Ford? EVERYONE understands that.

17 hours ago 3 1 0 0
All Places in London, England All Places in London, England

Atlas Obscura is good for this stuff, although at 563 entries it's a little overwhelming for London www.atlasobscura.com/things-to-do...

17 hours ago 0 0 0 0

Not exactly niche, but the Tate Modern and its spectacular reuse of an old power station is well worth visiting.

Didn't repeat anything else I saw in other replies but everything I saw was worth seeing.

17 hours ago 0 0 1 0
Maps, Atlases, Travel Guides, Travel Books and Globes The World's Biggest and Best Map and Travel Bookshop. For over 170 years, explorers, travellers and adventurers have looked to us as map specialists to get them where they need to go, and back again.

Visit Stanfords www.stanfords.co.uk

17 hours ago 0 0 1 0
The Thames Barrier - all you need to know! If you’ve heard of the Thames Barrier but you’re not exactly sure what it is, or if you know what it is but you’d like to know more about it, you’ve come to the right place

Take a ferry through the Thames Barrier. www.thamesclippers.com/blog/thames-...

17 hours ago 0 0 1 0

Oh man where to even start. Walk the Thames Path. tfl.gov.uk/modes/walkin...

17 hours ago 1 0 1 0
WITH astronauts AS (
  SELECT * FROM 'astronauts.parquet'
  QUALIFY ROW_NUMBER() OVER (
    PARTITION BY name
    ORDER BY mission_number DESC
  ) = 1
)
SELECT                                          
  *, 
  year_of_selection - year_of_birth AS age,
  'Age at selection' AS category
FROM astronauts
UNION ALL
SELECT 
  *, 
  year_of_mission - year_of_birth AS age,
  'Age at mission' AS category
FROM astronauts

VISUALIZE age AS x, category AS fill
DRAW histogram
  SETTING binwidth => 1, position => 'identity'
PLACE rule
  SETTING x => (34, 44), linetype => 'dotted'
PLACE text
  SETTING
    x => (34, 44, 60),
    y => (66, 49, 20),
    label => (
      'Mean age at selection = 34',
      'Mean age at mission = 44',
      'John Glenn was 77\non his last mission -\nthe oldest person to\ntravel in space!'
    ),
    hjust => 'left',
    vjust => 'top',
    offset => (10, 0)
SCALE fill TO accent
LABEL
  title => 'How old are astronauts on their most recent mission?',
  subtitle => 'Age of astronauts when they were selected and when they were sent on their mission',
  x => 'Age of astronaut (years)',
  fill => null

WITH astronauts AS ( SELECT * FROM 'astronauts.parquet' QUALIFY ROW_NUMBER() OVER ( PARTITION BY name ORDER BY mission_number DESC ) = 1 ) SELECT *, year_of_selection - year_of_birth AS age, 'Age at selection' AS category FROM astronauts UNION ALL SELECT *, year_of_mission - year_of_birth AS age, 'Age at mission' AS category FROM astronauts VISUALIZE age AS x, category AS fill DRAW histogram SETTING binwidth => 1, position => 'identity' PLACE rule SETTING x => (34, 44), linetype => 'dotted' PLACE text SETTING x => (34, 44, 60), y => (66, 49, 20), label => ( 'Mean age at selection = 34', 'Mean age at mission = 44', 'John Glenn was 77\non his last mission -\nthe oldest person to\ntravel in space!' ), hjust => 'left', vjust => 'top', offset => (10, 0) SCALE fill TO accent LABEL title => 'How old are astronauts on their most recent mission?', subtitle => 'Age of astronauts when they were selected and when they were sent on their mission', x => 'Age of astronaut (years)', fill => null

Dear lord

20 hours ago 3 0 0 0

Wrong answers only

3 days ago 2 0 9 0
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When Clark was asked Thursday if he planned to allow the current budget bill to have public hearings — after it had been sitting for two weeks at the committee stage with no movement — he was cagey.

"I've made no decisions," he said, a couple of hours before tabling his 1,238-word motion.

The motion also seeks to schedule one day each of public hearings on a bill that overhauls school board governance and another that prevents municipalities from requiring that developments follow certain environmentally friendly standards.

When Clark was asked Thursday if he planned to allow the current budget bill to have public hearings — after it had been sitting for two weeks at the committee stage with no movement — he was cagey. "I've made no decisions," he said, a couple of hours before tabling his 1,238-word motion. The motion also seeks to schedule one day each of public hearings on a bill that overhauls school board governance and another that prevents municipalities from requiring that developments follow certain environmentally friendly standards.

Combined with Conservative MPPs giving themselves months and months off, more and more the Ontario Legislative Assembly just seems to be a rubber stamp for Doug Ford cosplaying as a legitimate legislature.

3 days ago 10 2 0 0

Hot take: some hybrid seminar series should have speakers repeat their talks in each format at separate times rather than try to do both in-person and online simultaneously

3 days ago 5 0 0 1
Chromatin accessibility (often abbreviated or related to the concept of a11y in bioinformatics contexts, particularly when referring to open, accessible regions) refers to the degree to which nuclear DNA is accessible toDNA-binding proteins, such as transcription factors, histones, and RNA polymerase. It is a critical aspect of gene regulation, as inaccessible (compacted) chromatin restricts protein access, while open (accessible) chromatin allows for transcriptional activation

Chromatin accessibility (often abbreviated or related to the concept of a11y in bioinformatics contexts, particularly when referring to open, accessible regions) refers to the degree to which nuclear DNA is accessible toDNA-binding proteins, such as transcription factors, histones, and RNA polymerase. It is a critical aspect of gene regulation, as inaccessible (compacted) chromatin restricts protein access, while open (accessible) chromatin allows for transcriptional activation

DAE abbreviate the "accessibility" in "chromatin accessibility" as "a11y"?

I suspect Google AI Overview is making stuff open when it says "often" in bioinformatics contexts.

3 days ago 8 0 2 0

Jesus.

4 days ago 15 2 2 0

Forget it, Jesse

4 days ago 1 0 0 0

Please make it just "Distillery", ugh

5 days ago 7 0 0 0

I don't care for "the expression" if that makes sense.

5 days ago 1 0 0 0

The WSL team do good work.

5 days ago 2 0 0 0

Yes!

5 days ago 2 0 0 0

CG: Serendipity at the point of care can change lives. We have to get results back to point of care within less than a week #PMCBMP

5 days ago 0 0 0 0
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CG: Horace Walpole coined the term serendipity from a story that has nothing to do with luck, it's all about being prepared and observant #PMCBMP

5 days ago 0 0 1 0

CG: Colorado Center for Personalized Medicine is 4th largest academic biobank in U.S. #PMCBMP

5 days ago 0 0 1 0

CG: In informatics, serendipity is our industry. #PMCBMP

5 days ago 0 0 1 0

Continued 3: CG: Recount2 + PLIER = MultiPLIER #PMCBMP www.sciencedirect.com/science/article/pii/S240...

5 days ago 0 0 1 0
Pathway-level information extractor (PLIER) for gene expression data - Nature Methods Pathway-level information extractor (PLIER) uses prior knowledge of pathways to extract biologically interpretable latent variables from large gene expression datasets.

CG: PLIER #PMCBMP

5 days ago 1 0 0 0

CG: Can we learn reusable modules? Hypothesis: biologically meaningful patterns, including cell type information, can be learned from heterogeneous data. Use recount2 #PMCBMP

5 days ago 1 0 1 0

CG: Some things are missing. Others are misleadingly present. If gaps are inevitable, we should design experiments and systems that expose them. We've been trying to take everyone else's data and learn from it. The modular framework gap #PMCBMP

5 days ago 1 0 1 0

@jamespirruccello.com Don't miss this one

5 days ago 2 0 0 0

CG: Some genes are also often differentially expressed #PMCBMP https://www.pnas.org/doi/10.1073/pnas.1802973116

5 days ago 0 0 1 0
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CG: I'm super-lazy #PMCBMP

5 days ago 1 0 1 1