To be fair, though, it's Signal, not IRC.

Pancreatic cancer mRNA vaccine shows lasting results in an early trial Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

does this ply that you're reproducible?

we couldn’t make it public because the App Store restriction meant it needed to run off-device via a browser and we need to conserve server resources. my brother is a real computer whiz

Just because I live in the terminal, really. I want to be able to dogfood this as much as possible.

A series of three tweets: Rabbi Akiva Weisinger @MisfitTorah 1) For those wondering why I, an Orthodox Rabbi, am outraged by the Texas trans law, aren't I supposed to stand up for Torah Values or whatever A thread: 2) I don't like it when kids kill themselves. 3) End of thread.

Just going to leave this here.

Just had this from Planet Labs, the US government have asked satellite imagery providers for "voluntarily" restrictions on access to satellite imagery. Given a lot of them provide satellite imagery to the USG we can probably guess the outcome of not acquiescing to that request.

Ah, yes, the tech bro version of Pascal's Wager.

where haskell

It's True: Mamdani Is Fast Filling a Record Number of Holes By Adlan Jackson & 2 others • 2 Apr 2026

I don’t think his personal life is any of my business

linear algebra can't hurt you but capitalism definitely can

What's NixOS if not declarative Gentoo?

What is gentoo if not imperative NixOS?

Release Nvim 0.12.0 · neovim/neovim NVIM v0.12.0 Build type: Release LuaJIT 2.1.1774638290 Release notes Changelog (fixes + features) News (:help news in Nvim) Install Windows Zip Download nvim-win64.zip (or nvim-win-arm64.zip fo...

#neovim version 0.12.0 is out! Almost exactly a year of hard work since 0.11.0.

Huge thanks to everyone who worked on it, as well as to all Neovim users!

Release: github.com/neovim/neovi...
News: github.com/neovim/neovi...
Changelog: github.com/neovim/neovi...

Here are top 10 most liked features:

GitHub - epilys/bibliothecula: document organizer with tags and full-text-search, in a simple and clean sqlite3 schema document organizer with tags and full-text-search, in a simple and clean sqlite3 schema - epilys/bibliothecula

Since it's plaintext, I'm thinking of turning it into a Git repository and syncing it that way. However, I saw github.com/epilys/bibli... and got interested in turning it into a FUSE filesystem too; I'm still looking into what syncing would look like if I go that route.

it's just the right balance of actions and consequences.

`cargo run`? no, car go drive

I see, thanks! Any particular reason for doing so? I'm guessing it's to have a tighter integration with your notes, but even so, I'd imagine putting explanations in comments to work well enough.

On another note, I wonder if you've used Org-mode with Org-babel before? There's Org-roam for linking.

Mind if I ask how you code inside Obsidian's code editor? I'd imagine it to be quite painful.

I'd like to ask for some thoughts and opinions on what the syntax should look like and should saved queries be persistable as graph nodes too?

(9/9)

#rust #pkm

I think that the advantage is that

- you don't permanently lose information -- you don't know if you'd need it until you do, and
- the capture friction is lessened.

(8/9)

#rust #pkm

Second, querying is a priority for me. The idea is that, instead of carefully considering what to include and exclude in your notes to maintain a high signal-to-noise ratio, querying and filtering should achieve the same effect, without permanently information.

(7/9)

#rust #pkm

Two more open questions. First, should I expose user-defined types, and what should that interface look like?

(6/9)

#rust #pkm

One decision I’m stuck on is whether should actions such as create, edit, rename, and task-state-change be first-class objects in the graph alongside notes? If yes, should they come from Git integration, or live in my own action model, perhaps as TOML files?

(5/9)

#rust #pkm

In terms of UI, the default view would be a timeline, closer to Bluesky or Twitter. But when focusing on a note, I want something more like GitHub issues, with references, backlinks, and possibly a history or action view around that note.

(4/9)

#rust #pkm

Storage-wise, each note would be a folder named by its ID, containing `meta.toml`, `body.md`, and any attachments those might need. I also want Obsidian-style wikilinks, and note types such as task, event, and perhaps transaction later.

(3/9)

#rust #pkm

The capture UI I’m aiming for should feel closer to typing a tweet or sending yourself a text than filling in a form. No mandatory titles. Just a note, plus an optional and possibly empty list of aliases.

(2/9)

#rust #pkm

I’m building a command-line note-taking tool, with an Android app and web client planned for later. I’d like to ask some opinions on some aspects of its design.

(1/9)

#rust #pkm

228 FOR the extension of Chat Control 1.0. 311 AGAINST the extension of Chat Control 1.0.

307 AGAINST automated assessment of unknown private photos and texts. 306 FOR automated assessment of unknown private photos and texts.

🎉 The critical amendment 34 (rejecting automated assessment of unknown photos and texts) PASSED by ONE vote, paving the way for the extension of Chat Control 1.0 to be overwhelmingly REJECTED!

Initial analysis by @echo-pbreyer.digitalcourage.social.ap.brid.gy : www.patrick-breyer.de/en/end-of-ch...

You did it! 🥳

European Parliament just decided that Chat Control 1.0 must stop.

This means on April 6, 2026, Gmail, LinkedIn, Microsoft and other Big Techs must stop scanning your private messages in the EU. #PrivacyWins 💪