Hope this data is useful for extending in vitro cultivation of Toxoplasma to more life stages and as a benchmark for determining how similar different life stages are to merozoites and male and female gametes. Thanks again to Hisham for being willing to take on this bold project for his PhD.
Lots of ways to get at this data yourself. The easiest is to download the cloupe file available on zenodo.19358900
AP2X6 knockout parasites cannot make oocysts and we think this is because AP2X6 helps to repress expression of merozoite genes to promote female gamete development.
Hisham used single cell rnaseq on pre sexual and sexual stages to examine their developmental trajectories. He identified multiple stage specific genes and identified at least one that is required for oocyst production, AP2X6.
Our work just came out today in print form in Nat Micro. Really a tour de force from Hisham Alrubaye on sexual development in Toxoplasma gondii. Well done!
rdcu.be/feOj6
This meeting could’ve been a karate match
A snowy bus stop outside the NIH. Snow on the ground and sleeting down, everything is grey and white.
Fighting through snow so I can do my science. Animal care staff, building staff, clinical staff, nurses, doctors, veterinarians all work through these weather conditions to make the NIH run.
Yeah this is some serious grift. Gettin paid to kisss the ring.
Today I submitted a grant and I’m also getting a tooth pulled today which do yall think will be worse
I like these cause zoomed out they trigger a bit o trypophobia but zoomed in they don’t.
This is the fucking best. Rip city forever indeed
Sucrose being stirred in a beaker
Hello lab my old friend.
You are obligated to do so
Agree 100%
“I’m a transgender service member and today was my last day in uniform. After 11 years, eight months and 1 day I’m taking the uniform off for good.
I will always be yours bc this rank, these skills, this name will always be me.”
~Technical Sargent Altesse Aurum
#TransInMilitary 🫡 🏳️⚧️
@altessaurum
The U.S. National Science Foundation (NSF) has undertaken a review of its award portfolio. Each award was carefully and individually reviewed, and the agency has determined that termination of certain awards is necessary because they are not in alignment with current NSF priorities. Effective immediately, the following are terminated: NSF AWARD ID: 2120496 NSF is issuing this termination to protect the interests of the government pursuant to NSF Grant General Conditions (GC-1) term and condition entitled 'Termination and Enforcement,' on the basis that they no longer effectuate the program goals or agency priorities. This is the final agency decision and not subject to appeal. Costs incurred as a result of this termination may be reimbursed, provided such costs would otherwise be allowable under the terms of the award and the governing cost principles. In accordance with your award terms and conditions, you have 30 days from the termination date to furnish an itemized accounting of allowable costs incurred prior to the termination date. Sincerely, Jamie H. French, Division Director Office of Budget Finance and Award Management (BFA) Division of Grants and Agreements (DGA)
Today, we received notice that our team’s last remaining NSF grant was terminated. For the first time since 2009, when I received an NSF Fellowship for Graduate Research, I have no active NSF grants.
Heartbreaking effects of NSF, Americorps cuts to Pittsburgh’s after school programs that support and enrich our city’s kids.
The need and benefits of these programs is obvious. Isn’t this what we pay taxes for? Doubt philanthropy can take over.
www.publicsource.org/federal-fund...
This, more than anything else they are doing with funding levels etc, will ruin US Science and innovation.
Just called Gillibrand and Schumer to demand they not only vote against the murderous Republican budget bill, but that they deny unanimous consent at every opportunity and do everything else they can to gum up the works. This is intolerable.
Find your senators here and make your own calls: reps.fyi
⚖️Heartbroken but proud to stand with fellow researchers in court today⚖️
NIH’s sudden grant cuts:
🚫 Silence lifesaving health equity work
⏳ Undermine years of progress
⚠️ Put vital discoveries at risk
We won’t stop fighting for science & justice 🧪
👇More details from our @aclu.org representation👇
Text recognition in photo on your phone !!
Instead of “Here put this in your baby. AI told us it will be fine”
Amazing super cool and IMPOSSIBLE without a) NIH funding and b) ANIMAL RESEARCH
Ok so I agree re: HIM but sadly what he’s saying here is “do your own research and be skeptical of experts”.
The canceled grants aren't a perfect 1:1 with DEI-related projects, but what a reminder of who is and isn't doing the work to make science more equitable.
"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants.
Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
The intense racial and gender segregation of science funding will be even more pronounced going forward. This was always the intent.
they put french fries in sandwiches rich
that is what the heck is going on in pittsburgh
i am all for it tbh
