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Posts by Soham Mukhopadhyay

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How reCAPTCHA turned internet users into unpaid AI trainers The story of how solving โ€œthose annoying squiggly wordsโ€ helped digitize The New York Times, train autonomous vehicles, and build theโ€ฆ

gor-grigoryan.medium.com/how-recaptch...

1 week ago 1 0 0 0
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Home โ€“ genomepanel_nf Nextflow pipeline for reference genome mapping, SNP calling and quality checks on large genome panels

Resequencing hundreds or thousands of individuals from the same species has become routine... but processing all those genomes efficiently? Still a headache!

Here's my solution that used to be lab-internal but that I am happy to share:

crolllab.github.io/genomepanel_...

2 weeks ago 28 16 1 0

If the training program is only an introduction to Python and R and how to analyze a small transcriptomic dataset (which is the case in many institutes), then it makes sense.

1 month ago 1 0 0 0

Very excited to see this work out today!

Discovering viral immune antagonists directly from predicted protein structures. ๐Ÿคฉ www.science.org/doi/10.1126/...

Huge thanks to the amazing collaborators! ๐Ÿค—

1 month ago 24 9 2 0

@ismpmi.bsky.social

1 month ago 4 5 1 0
Close up of a Kalanchoe stem where white roots emerging from needle holes

Close up of a Kalanchoe stem where white roots emerging from needle holes

Emerged roots are green fluorescent as the agro strain injected carries a green fluorescent marker.

Emerged roots are green fluorescent as the agro strain injected carries a green fluorescent marker.

Close up of the green fluorescent roots emerging from the stem.

Close up of the green fluorescent roots emerging from the stem.

Plant weirdness. After injecting agro rhizogenes into the stem of Kalanchoe, they start sprouting roots from stem after few weeks later.

1 month ago 7 1 0 0

I recently reviewed a manuscript where the reviewer 3 submitted 5 pages of LLM nonsense ๐Ÿ˜…

1 month ago 1 0 1 0

True, it's a nightmare to juggle all those 'like', 'isoform x1' , 'like proteinโ€˜, etc. ๐Ÿ˜… For non-model plants, I always keep two annotationsโ€” one against the broad NR database and one just with Arabidopsis, and then cross-check.

1 month ago 0 0 1 0
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Is the lesson from this that, if ones reasoning is freed from the pull of gravity, one can still publish with MDPI?

1 month ago 3 2 0 0

@thaisdalsasso.bsky.social is applying new tools to address the evolution and functional diversification of secreted proteins of fungal plant pathogen. Preprint here: www.biorxiv.org/content/10.6...

1 month ago 18 15 0 0
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GitHub - Gaius-Augustus/Tiberius: Tiberius is a deep learning gene finder. Tiberius is a deep learning gene finder. Contribute to Gaius-Augustus/Tiberius development by creating an account on GitHub.

What we more recently learnt about Tiberius: the models trained on softmasked genomes are very sensitive to how the genome was masked for inference. It seems safer to use models trained on unmasked genomes. #genomeannotation #geneprediction github.com/Gaius-August...

2 months ago 12 2 1 0
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Out in @NaturePlants. We discover that the fungal pathogen Fusarium graminearum secretes an apoplastic effector that disrupts the N-glycosylation of a maize immune receptor, thereby inducing its degradation via selective autophagy. Very proud of the team~ doi.org/10.1038/s414...

7 months ago 23 7 1 0
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The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat Triticum turgidum cv Kronos Triticum turgidum cv Kronos is a tetraploid wheat cultivar that underpins one of the most widely used community platforms for functional genomics. Over the past decade, researchers have generated c.โ€‰...

Out in New Phytologist!

The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat cv. Kronos ๐ŸŒพ
chromosome-scale genome, high-conf annotations, manually curated 1000+ NLRs, ~3000 remapped datasets

๐Ÿ”— doi.org/10.1111/nph....
#Plants #Genomics #FunctionalGenomics

1 month ago 8 6 0 0

the estimated 1 billion biochemical reactions that occur every second in every cell of our bodies ๐Ÿคฏ

1 month ago 7 3 0 0
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Announcing the publication of TAIR12: Consult the fully reannotated genome on the European Nucleotide Archive - Phoenix Bioinformatics TAIR (The Arabidopsis Information Resource), together with our nonprofit host Phoenix Bioinformatics, is pleased to announce the public release of TAIR12

๐ŸŽ‰๐Ÿ“ฃ #TAIR12, the latest reannotation of the Arabidopsis thaliana genome, is now available under accession number PRJEB100887 on ENA and NCBI!

Thank you all the volunteer researchers whose hard work has made this possible!

#plantscience #plantbiology ๐Ÿงช

bit.ly/3ZHtneT

2 months ago 99 60 4 2
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Fitness effects of mutation: testing genetic redundancy in Arabidopsis thaliana Screens of organisms with disruptive mutations in a single gene often fail to detect phenotypic consequences for the majority of mutants. One explanation for this phenomenon is that the presence of p...

are you referring to the Rutter 2017 paper? onlinelibrary.wiley.com/doi/full/10....

2 months ago 1 0 1 0
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Dihydroxyhexanoic acid biosynthesis controls turgor in pathogenic fungi Many plant pathogenic fungi penetrate host surfaces mechanically, using turgor pressure generated by specialized infection cells called appressoria. These appressoria develop semipermeable cell walls ...

Out in @science.org this week, two fungal enzymes synthesise DHHA, which controls cell wall porosity and turgor in plant pathogenic fungi www.science.org/doi/10.1126/...

#mycology
#plantscience

2 months ago 50 22 0 0

๐Ÿ“ฃ Our latest story just dropped on bioRxiv:: A structurally unique effector shared between Verticillium dahliae and Fusarium oxysporum is involved in cotton defoliation and virulence on other hosts www.biorxiv.org/content/10.6... ๐Ÿงต

2 months ago 45 30 3 1
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MPMI Editorial Board

Thrilled to announce that I am joining the Editorial Board of Molecular Plantโ€“Microbe Interactions as a Senior Editor! ๐ŸŒฑ๐Ÿฆ  Grateful for the opportunity to serve this vibrant research community and help amplify impactful science ๐Ÿ‘

๐Ÿ”— apsjournals.apsnet.org/page/mpmi/ed...

2 months ago 34 3 1 0

Excited to join the team as Associate Editor!

2 months ago 1 0 0 0

๐Ÿ˜ฎ๐Ÿ˜ฎ

2 months ago 1 0 1 0

This article is now published! academic.oup.com/nargab/artic...
Weโ€™ve added a few new analyses. First off, we show that, while gene presence absence variation (PAV) scales with evolutionary distance in both plants and animals, the base level and rate of accrual are both twice as high in plants.

2 months ago 24 17 2 1
Krasileva Lab โ€“ Research Lab

๐Ÿ“ฃ Our lab is seeking a postdoc to study mutation mechanisms in fungi using cutting-edge sequencing + computational biology. No active posting/grant right now, but weโ€™re excited to host postdoc fellowship applicants in our comparative immunology team.
Interested? Reach out DM email. krasilevalab.org

2 months ago 18 16 0 0

He is strictly vegetarian, thus avoidance of excessive branched chain amino acids might explain this!

2 months ago 1 0 0 0
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A multi-plant transcriptomic atlas reveals conserved and lineage specific defense architectures in response to Botrytis cinerea Generalist pathogens pose a challenge to plant immunity by infecting diverse hosts while harboring extensive intraspecific genetic variation. Whether evolutionary distant plant lineages rely on a shar...

Ever wondered if diverse plant species respond similarly when infected by the same exact pathogen? Infect different asterids and rosids with the same Botrytis genotypes and teh short answer, quite differently.
www.biorxiv.org/content/10.6...

@annajomu.bsky.social @ccaseys.bsky.social

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3 months ago 34 24 1 0
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Dรฉjร  vu in clubroot resistance: same genes, new names Despite decades of clubroot research, only three resistance (R) genes have been validated. However, many of the โ€˜newโ€™ R genes are, in fact, identical to or allelic with these three. In this forum arti...

Although it went online in 2025, here is our second paper of 2026! ๐ŸŽ‰

Bravo to @jiaxuwu.bsky.social for leading this (possibly) controversial, but much-needed, analysis. Enjoy! Now out in the January 2026 issue of Trends in Genetics.

๐Ÿ”— www.cell.com/trends/genet...

3 months ago 13 5 1 1
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Towards a quantitative view of NLR evolution in genome space -- check out where we think the field of #NLR #evolution research is heading in this review led by Luzie Wingen and Aurรฉlien Tellier.
ecoevorxiv.org/repository/v...
#plantscience

3 months ago 26 18 0 0
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Food will be more affordable โ€” if we double funds for agriculture research now A global drop in public and private investment in agricultural science in the past four decades is partly to blame for high food prices, an analysis reveals.

Comment in @nature.com: "Food will be more affordable โ€” if we double funds for agriculture research now" www.nature.com/articles/d41...

A global drop in public and private investment in agricultural science in the past four decades is partly to blame for high food prices, an analysis reveals.

4 months ago 45 34 1 2
Intro to Bedder โ€“ The Quinlan Lab

We are thrilled to announce the first official release (v0.1.8) of #๐—ฏ๐—ฒ๐—ฑ๐—ฑ๐—ฒ๐—ฟ, the successor to one of our flagship tool, #๐—ฏ๐—ฒ๐—ฑ๐˜๐—ผ๐—ผ๐—น๐˜€! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.

1/n

4 months ago 298 152 5 11