Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr
Caroline Watson gives the first talk at the Mutations in Time and Space conference on the evolutionary road to AML #MITS2026
Pei-Chi Wei from @dkfz.bsky.social is the last speaker for Mutations in Time and Space 2026. Thanks to everyone who made it such a phenomenal meeting #MITS26
Great talk!! @imartincorena.bsky.social #mits26
Can't wait to read the paper: www.nature.com/articles/s41...
I'm currently on my way to Hinxton for Mutations in Time and Space 2026.
The attendee list is insane and I can't wait to see everyone- it's going to be a thrilling few days! #MITS26
coursesandconferences.wellcomeconnectingscience.org/event/mutati...
Wow! Congratulations Anna!!!
In vivo lineage tracing across human tissues using methylation barcodes in the protocadherin gene cluster www.biorxiv.org/content/10.64898/2026.02...
π§¬π§¬π§¬ REGISTRATION JUST OPENED! Make sure you join our DNA REPAIR MEETING 2026 ON PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY in Cologne, September 7-9, organized by the German Society for DNA Repair (DGDR) and the @dfg.de Research Unit 5504. www.for-5504.com/en/197/Confe...
Amazing!! Congratulations Sarah!
The abstract deadline for Mutations in Time and Space 2026 closes in 3 weeks time. Sign up here: coursesandconferences.wellcomeconnectingscience.org/event/mutati...
As well as thrilling science, the programme includes dinner at the beautiful King's College in Cambridge.
@eventswcs.bsky.social
Nature research paper: Decay of driver mutations shapes the landscape of intestinal transformation
go.nature.com/49VIh7w
For those interested in cooperativity within and between enhancers, @wbickmor.bsky.social and I wrote a mini-review and perspective, inspired by the many recent papers on this topic.
doi.org/10.1016/j.gd...
This is insanely cool!!!!!
Somatic and germline mutational processes across the tree of life www.biorxiv.org/content/10.64898/2025.12...
We are thrilled to announce the first official release (v0.1.8) of #π―π²π±π±π²πΏ, the successor to one of our flagship tool, #π―π²π±ππΌπΌπΉπ! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.
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π¨ Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease?
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
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Please repost π
Thrilled to announce that I'm on Curious Cases tomorrow at 10am on BBC Radio 4!
The episode - Immortal Jellies - looks at some remarkably long-lived species and what they can teach us about ageing. This is a key area of focus for our lab.
www.bbc.co.uk/sounds/play/...
@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude
Come to Germany and do a PhD with DKFZ. You'll be supported by an international community doing amazing science in a fantastic place.
I joined the DKTK from the UK 3 months ago and couldn't be happier with how easy it has been fitting in. The quality of work here is phenomenal and you should apply!
π£ Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry www.biorxiv.org/content/10.1101/2025.10....
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org π€©. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageingπ
Wellcome Connecting Science hybrid conference Mutations in Time and Space Conference dates: 13-15 April 2026 Location: Hinxton Hall Conference Centre, UK and online. Bursary deadline: 12 January 2026 Abstract deadline: 2 February 2026 In-person registration deadline: 16 March 2026 Virtual deadline: 6 April 2026
Explore the origins, patterns and consequences of mutations across biological systems! #MITS26
ποΈ Conference dates: 13-15 April 2026
Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing π§¬
Check out our exciting speakers β‘οΈ bit.ly/4hmbnyr
#Genomics
New preprint from another part of my PhD! ππ
Some mutations arise after fertilisation π§¬, so early they can appear in both a parentβs body and their germ cells.
By analysing family trio genomes πͺ, we built one of the largest catalogues of these βhiddenβ inherited variants yet.
tinyurl.com/mvns2ytv
Mutations in Time and Space is headed to Cambridge, UK for 2026!
You can check out the exciting list of invited speakers here: coursesandconferences.wellcomeconnectingscience.org/event/mutati...
See you at the Wellcome Genome Campus, on 13β15 April?
Nice one! ;-) #MITS26
Awesome @naxerova.bsky.social !!!!!
It's been a bumper week for super cool cancer genetics papers!!
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Our paper on clonal expansions in Sperm is out in Nature www.nature.com/articles/s41...
If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab
