JAMA cover, April 14, 2026, Volume 335, Number 14. Research: "text@1219" A Decision-Support System to Personalize Antidepressant Treatment. Opinion: "text@1201" Menopausal Hormone Labels Should Rely on Evidence. Clinical Review & Education: "text@1250" Chronic Diarrhea.

📌 Editor’s Choice from this week's issue of JAMA:

➡️ Chronic #Diarrhea Review,
➡️ Restrictive vs Liberal #ICU Physical Restraint,
➡️ Web-Based #Antidepressant Decision Tool, and more.

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Medical chart explaining adrenal insufficiency, its symptoms like fatigue, nausea, abdominal pain, muscle/joint pain, anorexia/weight loss, skin darkening, and treatments including daily steroids and fludrocortisone for Addison's disease.

Adrenal insufficiency occurs when the adrenal glands do not produce adequate amounts of certain essential hormones.

This JAMA Patient Page describes the types of adrenal insufficiency and its symptoms, diagnosis, and treatment. ja.ma/47YZNpE

An excerpt from JAMA, titled 'Heat and Pregnancy' under the JAMA Insights series on Climate Change and Health. It defines Heat injury, Heat stress, Heatstroke, Metabolic heat, Thermal heat capacity and Thermoregulation.

The frequency and intensity of heatwaves and the exposure of pregnant individuals to extreme heat are increasing.

💡 Learn more about the associated risks to maternal health and how these risks can be managed in this JAMA Insights. #ClimateChange

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JAMA Research Summary: Restrictive vs Liberal Physical Restraint Strategies. Low-use strategy: 196 patients. High-use strategy: 200 patients. Days alive without coma or delirium: Low-use strategy 6.67 days, High-use strategy 6.30 days.

📊 Research Summary: Restrictive vs liberal wrist-strap restraint strategies in ICU patients receiving mechanical ventilation produced similar outcomes for delirium, coma, self-extubation, and mortality.

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A clinical review titled Chronic, Noninfectious Diarrhea in JAMA, published online March 2, 2026. It includes a figure outlining clinical history elements for diagnosing the underlying etiology of chronic, noninfectious diarrhea and a diagnostic algorithm.

Chronic #diarrhea is defined by recurrent loose or watery stools, with or without increased stool frequency, fecal urgency, or fecal incontinence, that lasts for at least 4 weeks.

📄 Learn more about diagnosis and treatment strategies in this Review:
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JAMA cover: "Picking Antidepressants—Patient Preferences Beat Biomarkers" by Gregory E. Simon, MD, MPH. Article discusses antidepressant medication, remission rates, and personalized treatment research. Published online March 4, 2026.

💬 Editorial: Personalized #antidepressant selection using clinical criteria and patient preferences may yield better outcomes than biomarker-driven approaches for #depression.

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Infographic titled JAMA, presenting data about the PETRUSHKA tool study. It includes the question of tool effectiveness, a conclusion favoring the tool, population details(300 women, 220 men), intervention descriptions, location, primary outcome, & findings showing discontinuation rates.

In adults with major depressive disorder, the PETRUSHKA tool, which combines patient preferences and clinical predictors, was effective in personalizing antidepressant treatment and increased the likelihood of continuing treatment through 8 weeks.

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JAMA "Changes in Mifepristone Use at Pharmacies After Removal of the FDA In-Person Dispensing Requirement". Line graphs display trends from Jan@2021-Aug@2025 for: Pharmacy channel, Retail pharmacy type, Prescriber specialty, and State abortion access policy.

After the FDA removed in-person dispensing requirements, pharmacy-based #mifepristone use rose sharply via mail order in states where abortion and telehealth are permitted.

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Component bar graphs showing reduction in Tricuspid Regurgitation (TR) severity. A) Unpaired analysis: Baseline (n=1030) shows 96.7% None/trace. Postprocedure (n=1012): 64.5% None/trace, 33.0% Mild. B) Paired analysis: Baseline (n=747) shows 100% None/trace.

In patients with symptomatic, severe tricuspid regurgitation treated in routine US practice, transcatheter tricuspid valve replacement resulted in high implant success, significant symptom relief, and health status gains.

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Scatterplots show RHTP funding per rural resident vs state characteristics. A shows age-adjusted rural mortality rate vs variable RHTP funding. B shows projected federal Medicaid spending decreases vs variable RHTP funding. C shows % change in rural hospital beds vs funding. D shows % change in rural physicians vs funding.

Current allocations under the Rural Health Transformation Program are inversely associated with rural mortality and hospital bed losses, indicating that funding may not reflect clinical need.

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NY State Youth Justice Institute presents a Lunch & Learn webinar series. Topic: "Firearm Violence: Toward A Safer World by 2040; A JAMA Summit Report." Presenter: Terry Richmond, moderated by Melissa Tracy. April 15th, 12PM-1:15PM EST. Register at https://bit.ly/4re93gm

Join a free public webinar with Therese S. Richmond, PhD, RN, lead author of the JAMA Summit Report on Firearm Violence, discussing key findings and recommendations from the report.

📅 Apr 15 | 12-1:15 PM ET
🔗 Register: bit.ly/4re93gm

JAMA Clinical Reviews image displays 'Clinical Reviews' and 'JAMA'. Text: 'APRIL 13 14 MIN. Diagnosis and Management of Endometrial Cancer JAMA Clinical Reviews'. A play button is at the bottom.

Endometrial cancer accounts for 95% of uterine cancers, which are the fourth most common cancer in women in the US.

In under 15 minutes, JAMA Senior Editor Karen Lasser, MD, and gynecologic oncologist Karen McLean, MD, discuss key risk factors, hereditary syndromes, and more.

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JAMA viewpoint article "The First AI Drug Prescriber" by Daniel G. Aaron, MD, JD@1 and Christopher Robertson, JD, PhD@2. Published online April 13, 2026. doi: 10.1001/jama.2026.3533.

💬 Viewpoint: Utah authorized the first autonomous #AI drug prescriber for nearly 200 medications, bypassing physician oversight and FDA review, raising questions about safety and regulatory gaps.

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Diagram of the female reproductive system detailing endometrial cancer. Labels point to the uterus, ovary, fallopian tube, cervix, and vagina. Text lists risk factors and treatments for endometrial cancer.

This JAMA Patient Page describes common symptoms and signs of #endometrial #cancer, how it is diagnosed and treated, and the prognosis.

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Diagram titled "Endometrial Cancer A Review" published online April 13, 2026, showcases initial imaging, diagnosis, and surgical staging. It includes sections on healthy vs malignant endometrium, diagnostic sampling, and first-line management.

Uterine cancer is the fourth most common cancer in women in the US, with an estimated 68 270 new cases and 14 450 cancer deaths projected to occur in 2026.

📄 This Review summarizes the epidemiology, clinical presentation, and diagnosis of endometrial cancer.

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Line graphs show monthly mifepristone use by channel, retail store type, prescriber specialty, and state abortion access policy from January 2021 to August 2025. 'Mail order' and 'Independent' pharmacies show spikes after 'text@1'.

After the FDA removed in-person dispensing requirements, pharmacy-based #mifepristone use rose sharply via mail order in states where abortion and telehealth are permitted.

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JAMA editorial, published online April 13, 2026, titled "2025 Year in Review and Vision for the Path Ahead" by Kirsten Bibbins-Domingo et al. Discusses JAMA's focus on research integrity and global health challenges.

In their 2025 Year in Review Editorial, JAMA editors reflect on a year of change in medicine and public health, highlighting a continued commitment to rigorous evidence, global engagement, timely publication, and advancing scientific integrity to inform patient care.

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Two bar graphs titled "Component Bar Graphs of Reduction in Tricuspid Regurgitation (TR) Severity at Discharge and 30 Days With Transcatheter Tricuspid Valve Replacement", graph A is Unpaired analysis, and B is Paired analysis.

In patients with symptomatic, severe tricuspid regurgitation treated in routine US practice, transcatheter tricuspid valve replacement resulted in high implant success, significant symptom relief, and health status gains.

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JAMA viewpoint: 'Skinny Labels at the Supreme Court—Generic Competition, Patent Inducement, and Affordable Medicines'. By S. Sean Tu text@1, Frazer A. Tessema text@2, Aaron S. Kesselheim text@3. Published Online: April 9, 2026.

💬 Viewpoint: Judicial decisions narrowing the “skinny label” pathway for generics threaten affordable medicines and reduce timely competition for multi-indication drugs.

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JAMA article "Assessing Colorectal Cancer and Mortality Risk in Older Adults" by Christina P. Wang, MD; Brijen J. Shah, MD; Steven H. Itzkowitz, MD. Published online April 9, 2026.

💬 Editorial: For adults ≥75 years, 10-year #ColorectalCancer risk after adenoma removal is low and far exceeded by non-CRC mortality, supporting deprioritizing routine surveillance colonoscopy.

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JAMA cover: "Insufficient Sleep in Adolescents and the Need for System Changes" by Randi A. Bates, PhD, APRN-CNP; Tracy A. Lieu, MD, MPH. Published online March 2, 2026. Article discusses health risks and screen media's impact on adolescent sleep.

💬 Editor's Note: #Adolescents face increasing rates of insufficient sleep, driven by early school start times and digital media use, undermining cognitive and mental health.

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Figure 1, "Illustration of Bedside Assessment of Ocular Motor Function," shows methods for testing eye movement: A) Near-point convergence; B) Smooth-pursuit eye movements; C) Saccadic eye movements. Text: JAMA@1, JAMA@2, text@3, text@4

An estimated 1.1 million to 1.9 million #pediatric concussions occur annually in the US.

📊 This JAMA Rational Clinical Examination reviews the diagnostic accuracy of symptoms and signs observed in the initial evaluation of a child or adolescent who may have had a concussion.

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JAMA research letter shows a line graph depicting trends from 2017-2025 in patient-level use of manufacturer-sponsored coupons by therapeutic area(Anticoagulants, Antipsychotics, Obesity drug, Immunomodulator, Diabetes). Published online April 6, 2026.

Manufacturer-sponsored coupon use for brand-name drugs declined from 2017 to 2024 among US patients, but per-claim coupon amounts increased, especially for #Obesity and #Diabetes therapies.

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In this podcast, JAMA Deputy Editors Linda Brubaker, MD, and Preeti Malani, MD, MSJ, discussed the latest science published in JAMA:

➡️ Discontinuing Levothyroxine in Older Adults,
➡️ Cost-Effectiveness of Laboratory Goals for Lipid-Lowering Therapy, and more.

🎧 Listen now: ja.ma/4tJQWk9

Hear the latest on #PCSK9 inhibitors, #cardiorenal benefits of #GLP-1 drugs, and other clinical research in this interview with American College of Cardiology Conference Chair Katie Berlacher, MD.

🎧 Listen now: ja.ma/4cJkGa7

A JAMA article titled "Patient Safety Begins With Access: Safety Events That Occur Before Meeting the Patient" by Victor J. Hassid, MD, MBA; Haytham M. Kaafarani, MD, MPH. Published online March 11, 2026.

💬 Viewpoint: Administrative delays and access failures introduce patient safety risks but are rarely treated as safety events in health systems.

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JAMA Clinical Guidelines Synopsis: Management of Crohn Disease in Adults, published online April 8, 2026. Guideline title: Management of Crohn's Disease in Adults. Release date June 3, 2025. Prior version April 2018.

📊 JAMA Clinical Guidelines Synopsis: #CrohnDisease guidelines recommend fecal calprotectin for screening and monitoring, routine colonoscopy for colorectal cancer, and oral budesonide for induction in mild to moderate ileocecal disease.

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JAMA article graphs showing "Changes in Clinician Time Expenditure and Visit Quantity With Adoption of Artificial Intelligence-Powered Scribes: A Multisite Study." Graphs show EHR-8, DocTime-8, WOW-8, and weekly ambulatory encounters.

#AI scribe adoption across 5 academic centers was associated with modest reductions in EHR and documentation time, plus a slight increase in weekly visit volume, especially for primary care and female clinicians.

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Algorithm for Antiretroviral Treatment of Infants With In Utero or Intrapartum HIV Exposure by Risk of Transmission. It starts with a "Pregnant patient with HIV," then branches to "HIV RNA ≥50 copies/mL" or "HIV RNA <50 copies/mL" with subsequent steps.

The 2025 US Perinatal Guidelines designate bictegravir as a preferred antiretroviral regimen for patients with #HIV during pregnancy, supported by safety and efficacy data.

💡 Learn more in this JAMA Insights:
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Excited to be interviewed for JAMA Medical News about the promise of mRNA cancer vaccines and how misinformation may limit their impact. A reminder that scientific innovation and effective communication must go hand in hand.