#FragileNuclesome is back tomorrow! Join us to hear about exciting talks from:
- @au-ho-yu.bsky.social in @robklose.bsky.social's group about transcriptional control by SET1/MLL complexes
- @gcloner.bsky.social at @epicypher.bsky.social about the histone PTM landscape of the immune system
Join @stirlingchurchman.bsky.social,
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
Come join us in Geneva for everything epigenetics and gene regulation. It will be a great meeting! Please repost!
www.keystonesymposia.org/conferences/...
Nice to hear from you, Kinga! I had a feeling I was missing someone - I did see you asking questions, one more fellow Oxford alumni 🎓
Also surprised but very pleased to see so many friendly faces from my time at Oxford @ilandavis.bsky.social, Sina Wittmann, Adam Cawte, @flavia-con.bsky.social
Sad I couldn’t be there in person, but I really enjoyed listening to all the talks! What a great meeting with a unique focus on integrating single-molecule sequencing and imaging techniques. Excited to see how the field evolves!
Happy to share this paper! We uncovered that good 5' splice sites protect against ZC3H4/Restrictor's promiscuous role, and that its role is to suppress elongation and indirectly cause termination. Looking forward to learning more about this protein in the future!
‼️Last chance to join us in person for #EMBLSingleMolecule! Attend talks, network, socialise, and experience the atmosphere on the campus 🤩
🎫 Register by 3 Jun 👉🏼 http://s.embl.org/grg25-01-bl
🧬RNA processing
🧬Translation
🧬Transcription & chromatin regulation
🧬Method development
🧬Theory
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:
Our latest work now online in Cell:
Rewriting regulatory DNA to dissect and reprogram gene expression
Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression
Thread 👇
Oligo-LiveFISH is a high-resolution, reagent-based platform for studying 3D genome dynamics and their links to cellular processes in diverse cell types, including primary cells.
www.cell.com/cell/fulltex...
authors.elsevier.com/c/1kxK7L7PXu...
Interested in postdoc opportunities in Seattle, WA? Join us May 6th for Seattle DROP, a virtual event about biomedical research in Seattle. Hear from recruiting faculty, finding the right mentor and enjoy lunch on us via a delivery voucher within the US!
Registration: tinyurl.com/seattledrop25
My group is hiring a new Postdoc to work on gene regulation and chromatin in Nematostella. Please RT!
For more information see here:
gahanlab.com
tinyurl.com/34xke35d
Registration is now open for the 2025 Symposium on Physical Genomics, taking place Friday April 25 on Northwestern's Chicago campus - details at the link below. Planning on attending? Submit an abstract for the lunchtime poster session! #chromatin
physicalgenomics.northwestern.edu/news-events/...
📣 #EMBLSingleMolecule is open for registrations!
Our aim is to catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma. 🧬🔍
👉🏼 s.embl.org/grg25-01-bl
📅 15 – 18 July 2025
📜 Submit your abstract by 8 April!
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
Could stochasticity play a role in ensuring robustness during development?
Read this 'Behind the paper' story from Bernat Corominas-Murtra about his work with Dimitri Fabreges, @virginieuhlmann.bsky.social, @ehannezo.bsky.social, Takashi Hiiragi @hubrechtinstitute.bsky.social & co:
#DevBio
On the reading list
Congratulations on this exciting story coming out! You kept us all in suspense :)
Can't wait to read it in detail 🤓
Feel free to reach out if you have any questions!