Thank you so much for having me!

DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, th...

Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders.

www.biorxiv.org/content/10.1...

Interested in small molecule mechanism? If you’re at #ACSSpring2025, stop by the Eli Lilly Symposium Wed 9am–12pm @ Room 31A in the convention center. Cool talks from @michael-erb.bsky.social, Yuh Min Chook & @xiaoyuzhang.bsky.social. I’ll discuss our program on chemical genomics. Come check it out!

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...

🚨 Don't miss this recent research from the Zhang Lab 🚨
'Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation' #Cancer #Chemistry #ProteinDegredation

Out now in @J_A_C_S ➡️
pubs.acs.org/doi/full/10....

@xiaoyuzhang.bsky.social

Implications of frequent hitter E3 ligases in targeted protein degradation screens - Nature Chemical Biology This Perspective discusses recent strategies to expand the scope of targeted protein degradation (TPD) and the implications of unexpected convergence of diverse screening efforts on a small subset of ...

Thoughts on why DCAF11, DCAF16 and FBXO22 could be the next workhorse E3 ligases in TPD
doi.org/10.1038/s415...

🧪 Ready, set, degrade!

So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.

Link: www.jci.org/articles/vie...

Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...

Somatic FBXW7-R465C mutant shows promise in targeted protein degradation in cancer cells. This approach enhances protein degradation specificity in diseased cells. Congrats Xiaoyu Zhang and colleagues. 🧪 #chembio #TPD #CancerResearch

www.biorxiv.org/content/10.1...

Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing!
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7