The PALS Summer School in Transcriptomics, I promise, will be a unique experience
www.trippus.net/summerschool...
23-26 June 2026 in a hidden Swedish paradise 🇸🇪🫎
We have extended the deadline to May 15 or until availability
@scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social
We are looking for a postdoc to join us on the quest for understanding RNA Pol II destruction machines! If you are curious why more than 80% of Pol II are removed from genes, check out the post below:
www.nature.com/naturecareer...
Join us this Wednesday to hear about fascinating research from @kashyapchhatbar.bsky.social and @a-radzisheuskaya.bsky.social!
If you're not already registered, click here to sign up: us06web.zoom.us/webinar/regi...
you can also join the conversation at our discord: discord.com/invite/dXqT89r
Ugghhh
OK Kids, our ERK story is finally heading out into the world. After 9 years of having funding, losing funding, losing staff, getting funding, gaining staff...it's ready!
We discovered a novel stage of what is an otherwise extensively studied process: how cells respond to extracellular signals. 1/n
I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.
ChromSMF preprint is out!🚀
tinyurl.com/ChromSMF
We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting!
In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬
What does this unlock? ⬇️
Congrats to Pelin on the new preprint examining hormone responsiveness in mammary organoids! Excited to see what she does next with the system she's developed 🧬!
www.biorxiv.org/content/10.6...
Congrats to Pelin on the new preprint examining hormone responsiveness in mammary organoids! Excited to see what she does next with the system she's developed 🧬!
www.biorxiv.org/content/10.6...
It’s tradition for labs to make the defense posters for the students defending! Huge shoutout to mine for hitting the nail on the head lol. Interested in what I’ve been doing during my PhD (both science and non-science!)? Message me for the Zoom link or come in-person if you’re in the area 😊
🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...
We have another exciting #FragileNucleosome seminar for you next week! @sunil-k-pradhan.bsky.social and
Genevieve Fourel will share their fascinating stories on chromatin and genome organization.
Click here to register: us06web.zoom.us/webinar/regi...
🫣 well, here we go!
daylight savings in the USA skipped us forward 1 hour, so we might be starting 1 hour earlier for some. Check your time against 9:00 PDT / 12:00 EDT (instead of PST/EST) to ensure you've got the correct start time for tomorrow!
How do the H2A.Z histone variant and its dedicated chromatin remodeller SRCAP regulate gene expression ?
Beautiful work from @armelletollenaere.bsky.social now published @ www.nature.com/articles/s41...
Flyer for symposium: https://ctrlepiedit.sciencesconf.org/
Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org
⚡This Wednesday! 🥁We've got two exciting chromatin talks coming up from @almassalha.bsky.social and @carmeloferrai.bsky.social
🐣If you haven't registered for the series, please register and join us: us06web.zoom.us/webinar/regi...
Delighted to see this published: H3K115 acetylation is associated with fragile nucleosomes at CpG island promoters and active regulatory sites. Great work from all contributors; Yatendra Kumar, @illingworth-lab.bsky.social @eliasfriman.bsky.social @helink.bsky.social
doi.org/10.7554/eLif...
Wahoooo it’s online!!! 🎉🥳
Excited to share a glimpse into my postdoc work with @chorye.bsky.social at Duke where @stefan-golas.bsky.social and I developed TurboPRANCE, a robotics platform to scale and enable new phage-assisted continuous evolutions. bskytorial party!👇 1/n
Evolution navigated billions of challenges to get to us to where we are today. Directed evolution compresses this to a 1D axis.
Imagine if you could sample 200 dimensions at once, with data to boot 📈
First @chorylab.bsky.social PACE preprint on our new system to tackle this: bit.ly/turboprance
Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar.
Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse.
www.biorxiv.org/content/10.6...
Three @biorxivpreprint.bsky.social preprints on acute depletion of FACT in ES cells. First, from my colleague at Pitt Sarah Hainer's lab 1/ www.biorxiv.org/content/10.6...
Join us tomorrow for two exciting enhancer talks!
Preprint alert 🚨Happy to share my first Posdoc manuscript from the Vos lab @voslab.org. We introduce GATO-seq, a high-throughput, fully in vitro technique that maps RNA polymerases at base pair resolution over time. Using it, we found a new pause state of Pol II: sidetracking tinyurl.com/superpause
Next week on Fragile Nucleosome:
🧬 Pavan Choppakatla from the Levine lab will share his work on long-distance enhancer-promoter search
🧬 @moorejille.bsky.social will tell us about millions of enhancers in the registry of candidate CREs
Register here and join us!: us06web.zoom.us/webinar/regi...
Looking forward to it!
Updated job posting description for our postdoc recruitment to include interest in immuno-oncology
Interested in transcriptional regulation, enhancers and 3D genome folding?
In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control
www.biorxiv.org/content/10.6...
detailed 🧵👇
Tomorrow!
Two exciting talks on tap from @ambystoma22.bsky.social and @epijenatics.bsky.social at @fnucleosome.bsky.social seminar!
