Well, this is interesting...

www.science.org/doi/epdf/10....

Boop (of course)

On something new? No, still waiting (im)patiently. On a supplement submitted and reviewed in December 2024? Yes. In February 2026. 🫠

A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation | PNAS The Arg/N-degron pathway of Saccharomyces cerevisiae is mediated by two interacting E3 ubiquitin ligases, Ubr1 and Ufd4. We show here that the mito...

A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation www.pnas.org/doi/10.1073/...

1/ How does the cytosolic iron–sulfur cluster assembly (CIA) system identify its dozens of clients?

Like any good CIA agent, it uses a secret code🕵️ … and we think we’ve found the decoder.

New Perlstein Lab preprint:
www.biorxiv.org/content/10.6...

Purify and set up trays. No crystals or poorly diffracting? Go back and cleave 🤷‍♂️ lovely His tag there! 😁

Is "NDC" how eRA is displaying this now...? Not sure.

Pleased to be hosting Prof. Molly Sutherland of @udelaware.bsky.social here at @umbc.bsky.social Chemistry & Biochemistry! A great talk today from 12 - 1 pm in Meyerhoff 120 entitled: "How does heme move? Insights into heme trafficking from the bacterial cytochrome c biogenesis pathways" 🧪🧬⚛️

Check out #ACSBIOL’s session on the Bristol Myers Squibb Award in Enzyme Chemistry and Chemical Biology from 8-12 PM tomorrow morning (Wednesday, March 25) in Conference Center room B206! Professor Tom Muir will give his awardee lecture at 11 AM!
#ACSSpring2026

Thrilled to share our HFSP grant "Revealing the Hidden World of Heme Proteins in True Colour" has been funded! An international collaboration with Jennifer Ogilvie (Canada), Michel Sliwa (France), & Philipp Kukura (UK) to develop label-free single-molecule imaging of heme transport and trafficking.

OMG @acs.org added an option to just view the #ACSSpring2026 program as a searchable PDF BLESS
Link: acs.digitellinc.com/p/s/acs-spri...
Direct download: acs.digitellinc.com/products/658...
Ctrl + F "BIOL: Division" for 🔥

#ACSSpring2026 is less than a week away! Check out the full list of #ACSBIOL sessions and speakers here: tinyurl.com/ACSSpring26

It can certainly be (emotionally) dangerous if your lab has key access to your office! 🥹

Aluminum, Helium and Sulfur: The Iran War Is Affecting More Than Oil

NYT: "Aluminum, Helium and Sulfur: The Iran War Is Affecting More Than Oil"

www.nytimes.com/2026/03/10/b...

Likewise, it was great! Could only be there for a couple of days, unfortunately...Hoping Boston has more metalloproteins :)

Last day at #discoverbmb2026 #asbmb2026
@asbmb.bsky.social ! My lab and all of the UMBC-UMB T32 CBI students had a blast! Looking forward to Boston next year!

While I haven't been able to be at the whole meeting, I've been heartened and reinvigorated by the spirit of all of the great science so far at #discoverbmb2026 #asbmb2026 @asbmb.bsky.social ! Plus, look at all those great UMBC T32 CBI trainees networking and sharing their science. Inspirational!

Love a good 4(Cys) Fe-binding site :D

Well-deserved!!

PhD and Postdoc Transition Program | Gilliam Fellows | HHMI The Gilliam Fellows Program supports PhD students and their faculty thesis advisors to advance cutting-edge research, facilitate the transition to postdoctoral scientist, and foster the development of...

2nd- or 3rd-year PhD student? Applications for @hhmi-science.bsky.social's #GilliamFellows Program open 9/1! Robust dissertation support, an incredible community of scientists, tailored professional development (for you *and* your faculty thesis advisor), & so much more. Bookmark bit.ly/4qQArRh!

Huge congratulations to grad student @katherinelegg.bsky.social on her new Science Advances paper, “CH•••S hydrogen bonds drive molecular recognition of ergothioneine by the microbial transporter”! 🎉 A beautiful collaboration of biochemistry, structural biology, NMR, and MD. tinyurl.com/3wxchjhp

Super pleased (and surprised?!) to receive an NOA earlier this week for a supplement supporting a PhD candidate in the lab! A little bit of sunshine in the middle of the storm, I suppose...

Senior Scientist, Protein Sciences in South San Francisco, California, United States of America | Research & Development at Genentech Apply for Senior Scientist, Protein Sciences job with Genentech in South San Francisco, California, United States of America. Research & Development at Genentech

Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.

Co-translational control of protein stability and quality in plants Abstract. Proteostasis relies on the coordinated control of protein synthesis, folding, modification and degradation, and an increasingly clear picture is

My review “Co-translational control of protein stability and quality in plants” is now online at @jxbotany.bsky.social, in which I describe how co-translational processing and ribosome-associated quality control together establish protein stability and fate early in synthesis. tinyurl.com/5dhhz9h6

X-ray beam effects on metallo-peptides reflect redox events: insights from X-ray absorption spectroscopy measurements on metal complexes of truncated amyloid-β peptides X-ray exposure influences the structures of Cu(I), Cu(II) and Zn(II) complexes of amyloid-β (Aβ) peptides in different ways. While Cu(I) and Zn(II) complexes show no detectable X-ray-induced spectral changes, Cu(II) complexes undergo significant spectral evolution under irradiation. Experiments on the truncated fragments Aβ1–6 and Aβ1–16 show that the extent of relaxation depends on the peptide length, on the binding mode and on the temperature.

Bharath Vinjamuri et al.: X-ray beam effects on metallo-peptides reflect redox events: insights from X-ray absorption spectroscopy measurements on metal complexes of truncated amyloid-β peptides @UGrenobleAlpes...#IUCr https://journals.iucr.org/paper?S2059798326001348

The structure of the full catalytic cycle of Vibrio cholerae NFeoB The acquisition of iron is critical for the survival and the virulence of numerous infectious pathogens, and most bacteria acquire ferrous iron (Fe2+)…

🚨 Just in press @jmolbiol.bsky.social 🚨 Kate, Candice, and Mark's paper on the structure of the V. cholerae NFeoB NTPase catalytic cycle. Serendipity of a P1 spacegroup with 4 mols in the ASU played a role in capturing all the states, and Mg is pivotal! Read the paper here: tinyurl.com/mr3dmmjz

🚨New paper: We found - contrary to expectations - that oxygen is partially excluded from biomolecular condensates.

We find a strong anti-correlation between oxygen and protein concentrations in the condensate showing that accessible volume dominates over polarity.

www.nature.com/articles/s41...

Postdoc: Integrative structural biology and biophysics of dynamic plant hormone transporters - Ledig stilling på Aarhus Universitet Ledig stilling ved Institut for Molekylærbiologi og Genetik - Proteinvidenskab, Aarhus Universitet

🚨Postdoc opening: Integrative structural biology and interactions of disordered regions in plant transporters.

Skills sought: Protein experience (ideally IDPs/MPs), NMR, SAXS, smFRET, biophysics and similar.

Come find me at #BPS26 or reach out to learn more!

mbg.au.dk/aktuelt/ledi...

😬

Science is still correct even if you don’t believe in it…