How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology!
Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.
Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations www.biorxiv.org/content/10.64898/2026.04...
Kim, J., Jeong, H., Falcó, C., Hruska, A. M., Martinson, W. D., Marzoratti, A., ... & Wong, I. Y. (2026). Collective transitions from orbiting to matrix invasion in three-dimensional multicellular spheroids. Nature Physics, 1-12. #EpithelialMechanics
buff.ly/ChmS1uW
Out today in Nature Physics! doi.org/10.1038/s415...
It was highlighted by Brown News: brown.edu/news/2026-01...
Huge thanks to my amazing co-authors Hyuntae
@htjeong.bsky.social and Carles, and deepest gratitude to my mentor Prof. Ian Y. Wong @ianywonglab.bsky.social for leading this journey. 🧵
Published online today in Nature Physics - we show how multicellular spheroids round up and orbit, driving a deterministic transition to 3D matrix invasion at predictable locations.
Amazing work from @jiwon-kim.bsky.social, @htjeong.bsky.social and collaborators
www.nature.com/articles/s41...
I'm very happy to share my first article as a corresponding author published in @natmethods.nature.com !! 😍
Some groups (like us) have developed complex 3DTFM methods in the last 15 years.
BUT its usage in studies that help better understand disease or development has been almost non-existent.
Engineers and biologists join forces to explore the mysteries of vimentin intermediate filaments!
Learned so much from Ming Guo, @aaandmoore.bsky.social, Ohad Medalia, Jennifer Lippincott-Schwartz, Dave Weitz, and Bob Goldman. Thanks to @natcellbio.nature.com for thoughtful edits
rdcu.be/ezkWF
Congratulations!!!
Many thanks to Brown Engineering and @tejaladesai.bsky.social for the Dean's Award for Excellence in Mentoring
Grateful for the talented students and postdocs in my lab - it's a privilege to work with you during these formative stages of your careers.
engineering.brown.edu/news/2025-05...
Congratulations! Exciting news
Excited to start collaborating on Anti-Cancer Immunoengineering with @weldeiry.bsky.social
www.brown.edu/academics/ib...
Honored to be interviewed by @naturemethods.bsky.social about my lab philosophy
Many thanks to Vivien Marx @vivienm.bsky.social for writing this and the many lab members past and present who have collaborated scientifically.
nature.com/articles/s41...
Collective Transitions from Orbiting to Matrix Invasion in 3D Multicellular Spheroids www.biorxiv.org/content/10.1101/2025.02....
Inspired by a brilliant Gordon conference on directed cell migration 🤔
Many thanks to Sally Horne-Badovinac and Robert Insall for all their hard work! @robinsall.bsky.social
