Check out the latest study from our lab, led by @mhall98.bsky.social :
www.biorxiv.org/content/10.1... (1/2)

Functional microRNA targeting without seed pairing MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to serve as guides, directing binding to partially complementary sites in mRNAs, ultimately causing post-transcriptional repression. Compleme...

Pleased to share my recent work from the Bartel Lab! Some miRNAs recognize novel target sites called 3'-only sites, which pair to the miRNA 3' region but not to the seed. These sites direct mRNA repression in cells and are engaged by different mechanisms to seed sites
www.biorxiv.org/content/10.1...