Sybren Worm et al. from the Medical University of Vienna investigate the effects anesthesia on retinal OCT parameters and physiological dynamics as in C57BL/6J mice.
doi.org/10.1167/iovs.67.4.50

Sanhita Roy et al. from the LV Prasad Eye Institute evaluate a novel inositol acyltransferase (Gwt1) inhibitor for fungal keratitis treatment.
doi.org/10.1167/iovs.67.4.49

Shuning Li et al. from Beijing Tongren Eye Center evaluate 6-year changes in optic nerve head (ONH) perfusion using optical coherence tomography angiography (OCTA) in non-highly myopic eyes with peripapillary fundus tessellation (pFT).
doi.org/10.1167/iovs.67.4.48

Chunhui Jiang et al. from Fudan University evaluate the safety and efficacy of cceAAV-aflibercept-Fc-YTE (F-CRG-B191), a gene therapy for neovascular AMD.
doi.org/10.1167/iovs.67.4.47

Tao Guo et al. from Shanghai Jiao Tong University School of Medicine investigate the role of TXNDC5 in POAG in promoting extracellular matrix protein accumulation and raising intraocular pressure.
doi.org/10.1167/iovs.67.4.46

Zhaohui Liu et al. from Beijing Tongren Hospital investigate brain microstructural alterations in children with basic-type intermittent exotropia using mean apparent propagator magnetic resonance imaging and analyze their correlations with clinical signs.
doi.org/10.1167/iovs.67.4.45

Ka Yee Kam & Dorita H. F. Chang from The University of Hong Kong investigate retinal-specificity of sensory eye dominance and its learning-induced improvements.
doi.org/10.1167/iovs.67.4.44

Ruikang K. Wang et al. from the University of Washington Hyporeflective investigate the optical mechanism and impact of the artifactual bending of Bruch's membrane beneath hyporeflective core drusen on optical coherence tomography.
doi.org/10.1167/iovs.67.4.43

Xiaona Li et al. from Taiyuan University of Technology find that LncRNA DANCR regulates PARP1-mediated oxidative stress response in corneas by encoding a novel micropeptide miPEPDR.
doi.org/10.1167/iovs.67.4.42

Feng Wen et al. from Zhongshan Ophthalmic Center perform longitudinal tracking of photoreceptor integrity in neovascular AMD finding that early restoration predicts 24-month structural and visual outcomes.
doi.org/10.1167/iovs.67.4.41

Jonathan F. Russell et al. from the University of Iowa develop a porcine model of rhegmatogenous retinal detachment associated with posterior vitreous detachment (PVD) that can be used to evaluate surgical repair with small-gauge pars plana vitrectomy.
doi.org/10.1167/iovs.67.4.40

Bela Anand-Apte wt al. from the Cole Eye Institute find that insulin induces outer blood–retinal barrier disruption via downregulation of claudin-19.
doi.org/10.1167/iovs.67.4.39

Wen-Bin Wei et al. from Beijing Tongren Eye Center investigate the effects of HO-1 on the integrity of retinal pigment epithelial cells in regulating axial elongation in experimental myopia.
doi.org/10.1167/iovs.67.4.38

Rajeev H. Muni et al. from the University of Toronto describe a biomechanical model of outer retinal corrugations and bacillary layer detachment in rhegmatogenous retinal detachment.
doi.org/10.1167/iovs.67.4.37

Lin Zhang et al. from Sichuan University identify the genetic cause of autosomal dominant congenital cataract in a large family and define how a CRYBB2 splice-site variant perturbs lens development and associated ocular phenotypes.
doi.org/10.1167/iovs.67.4.36

Bang Bui et al from The University of Melbourne examine whether the response of the rat optic nerve tissue to either acute or chronic intraocular pressure elevation is affected when optic nerve sheath pressure is reduced via optic nerve sheath fenestration.
doi.org/10.1167/iovs.67.4.35

Pablo Artal et al. from Universidad de Murcia evaluate the contrast reduction profiles of different myopia control spectacles to better understand their underlying mechanisms.
doi.org/10.1167/iovs.67.4.34

Sabine Fuhrmann et al. from Vanderbilt University Medical Center provide direct comparison of constitutive Rax-Cre transgenic drivers that activate in the mouse embryonic eye field.
doi.org/10.1167/iovs.67.4.33

Ai Zhuang et al. from Shanghai Jiao Tong University School of Medicine explore the molecular and metabolic underpinnings of uveal melanoma pathology using regionally resolved proteomics.
doi.org/10.1167/iovs.67.4.32

Stephen C. Pflugfelder etl al from the Baylor College of Medicine find that rexinoid NEt-3IB promotes resident macrophage gene expression and mitigates desiccation-induced ocular surface disease.
doi.org/10.1167/iovs.67.4.31

Yanlong Bi et al. from Tongji Eye Institute find that modulation of iron-induced glucose metabolic reprogramming alleviates retinal pigment epithelial cell senescence.
doi.org/10.1167/iovs.67.4.30

Fred K. Chen et al. from Lions Eye Institute characterize the clinical features, electrophysiology, and variant spectrum in ABCA4- and PRPH2-retinopathies and identify novel electrodiagnostic biomarkers to differentiate between the two genotypes.
doi.org/10.1167/iovs.67.4.29

Joshua L. Dunaief et al. from the University of Pennsylvania Perelman School of Medicine find that oral deuterated docosahexaenoic acid protects against onset and progression of RPE degeneration in a mouse model of chronic oxidative stress.
doi.org/10.1167/iovs.67.4.28

Michaël J. A. Girard et al. from Emory School of Medicine investigate the contribution of the Bruch's membrane and sclera tissues to the overall structural integrity of the ocular wall.
doi.org/10.1167/iovs.67.4.27

Xiangyi Wen et al. from West China Hospital, Sichuan University find that overexpression or activation of potassium channel TASK-3 protects retinal ganglion cells and restores visual function in optic nerve crush.
doi.org/10.1167/iovs.67.4.26

Hiroyuki Namba, Tomohiko Usui et al. from the International University of Health and Welfare Narita Hospital evaluate microcirculation at the optic nerve head (ONH) in eyes with keratoconus.
doi.org/10.1167/iovs.67.4.25

Dror Sharon et al. from The Hebrew University of Jerusalem investigate the the genetic landscape of inherited retinal diseases in the Israeli population.
doi.org/10.1167/iovs.67.4.24

New review article by Qiuli Fu et al. from Zhejiang University discusses the role of biomechanics in age related cataract pathogenesis and summarizes recent advances in understanding related mechanisms.
doi.org/10.1167/iovs.67.4.23

Ludvig J. Backman et al. from Umeå University use proteomic analysis of human corneal keratocytes to reveal mechanical strain–dependent changes in cellular function.
doi.org/10.1167/iovs.67.4.22

Masahito Yoshihara, Takayuki Baba et al. from Chiba University Graduate School of Medicine use metabolomic profiling of vitreous humor to reveal distinct metabolic signatures in proliferative vitreoretinopathy.
doi.org/10.1167/iovs.67.4.21