Epigenetic Set-Point: A biophysical integrator of plant developmental transitions. (1) Analog Inputs: Environmental cues, metabolic status, and redox signals (ROS/NO) converge to modulate the chromatin landscape. (2) Threshold Modulation: These signals regulate the kinetic barrier (ΔG‡) by governing writers (PRC2), erasers (JMJ), and readers (LHP1). Redox-mediated ‘eraser jamming’ and metabolic licensing lower this barrier. (3) Digital Outcomes: Crossing the threshold triggers a stable, bistable ‘Digital Lock,’ enabling predictive phenology and epibreeding targets. TOR, Target of Rapamycin; ROS, reactive oxygen species; NO, nitric oxide; PRC2, Polycomb Repressive Complex 2; JMJ, Jumonji demethylase; LHP1, LIKE HETEROCHROMATIN PROTEIN 1; ΔG‡, effective kinetic barrier.
Epigenetic set-point: how plants filter noise vs signals to decide when to flower and adapt
Latif Ahmad Peer
nph.onlinelibrary.wiley.com/doi/10.1111/...