Interferon Stimulatory DNA activates the DNA damage signaling through ATM and DNA-PK sensing In eukaryotic cells, DNA is normally confined in the nucleus and mitochondria and the presence of DNA in the cytoplasm is a danger signal that activates innate immune responses. Upon detection of cyto...

Happy to share the first research article of our team. We report that foreign DNA, such as ISD, activates DNA damage signaling mainly through DNA-PK.

@ircan.bsky.social @univcotedazur.bsky.social @cnrsbiologie.bsky.social @canceropolesud.bsky.social

www.jbc.org/article/S002...

I will attend the CSHa meeting on Genome Integrity and Cancer in Suzhou, China. I am looking forward for interacting with peer colleagues there.
www.csh-asia.org?content/2904
@ircan.bsky.social @univcotedazur.bsky.social

Chromoanagenesis This book explores chaotic genomic rearrangements, known as chromoanagenesis, their formation mechanisms, and the techniques used to detect them.

If you are interested in chromosomal instability, micronuclei and more, I suggest reading this book: link.springer.com/book/10.1007...
We wrote chapter on transcription-replication conflicts and micronuclei with my mentor @paserolab.bsky.social @ircan.bsky.social @univcotedazur.bsky.social

Follow our research and lab here: www.ircan.org/research/tea...
If you are interested in joining the lab, we are looking for our future labmates and for future students, at all levels.