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Posts by Matthew Sydes

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A proposed charter for clinical trial data monitoring committees: helping them to do their job well Formal monitoring of data from randomised controlled trials (RCTs) is becoming more common. Wide variation exists in the structure and organisation of data monitoring committees (DMCs), with little gu...

Founders Lecture #SCT2025 on DMCs - Thomas Fleming flags the @nihr.bsky.social funded DAMOCLES study that developed a charter for DMCs to support them to do their jobs well. Full paper here www.thelancet.com/journals/lan...

11 months ago 3 2 0 1

Hard to believe it is now 20 years (!) since we published the DAMOCLES Charter to support data monitoring committees do their job well. It is still routinely used to inform all NIHR DMCs today 😊
@mattsydes.bsky.social

11 months ago 7 4 0 1

My most recent blog post for NHSE on clinical trials is here: digital.nhs.uk/blog/data-poin…

It's my contribution for #ClinicalTrialsDay.

It's a personal story.

My take-away message for you is: "Every person that ... joins any trial is a hero."

11 months ago 6 2 2 1

And some bonus #TrainMisery. No work anniversary would be complete without a reminder of how many times I've been let down on the commute to London.

5/5

1 year ago 1 0 0 0

I tried to catch a panel session on #AI and real-world data #RWD across London to end the day but the stars didn't quite align to catch it all.

("Good" to see those organiser's had made a classic Trials / Trails typo on their banner stands. Don't see that much now...)

4/5

1 year ago 2 0 1 0
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Then gave on talk on #HealthcareSystemsData and the NHS Research SDE Network #SecureDataEnvironments and Clinical Trials in a great afternoon session at @imperialctu.bsky.social Contemporary Clinical Trials Methodology Meeting.

3/5

1 year ago 2 0 1 0
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I helped chair a good session on Trials and #NHSDigiTrials at today's Health Data User Group #HDUG meeting. (Sign up for the next one via data.healthresearch@nhs.net) @NHSDigital

2/5

1 year ago 1 0 1 0
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It is my 30th anniversary of working in #ClinicalTrials today! I don't think I feel old enough to have hit this milestone, yet started at MRC Cancer Trials Office on 03-Apr-1995.

How to celebrate? Talking about better clinical trials, of course! Here's how...

1/5

1 year ago 26 3 3 0
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This morning, I helped chair a good session on trials and #NHSDigiTrials at today's Health Data User Group #HDUG meeting. digital.nhs.uk/data-and-inf...

1 year ago 0 0 0 0

It helps show direction of research community & set priorities for how we build invitations to participate in research with the richness of healthcare systems data the SDE Network will hold.

1 year ago 0 0 0 0

And it's not just about this year: express your interest now for ideas you want to run in the future.

Signalling your interest, incl. in working with datasets that aren't yet easily available, is good.

1 year ago 0 0 1 0
QR code which links to the hyperlink already in the text. 
And clarification that applications for FY25/26 should be submitted by 11-Apr-2025

QR code which links to the hyperlink already in the text. And clarification that applications for FY25/26 should be submitted by 11-Apr-2025

Snapshot of the LinkedIn post at https://www.linkedin.com/posts/nhs-transformation-directorate_nhsdigitrials-clinicalresearch-healthcare-activity-7302360165935140866-ZQHG title "Transforming clinical trial recruitment"

Snapshot of the LinkedIn post at https://www.linkedin.com/posts/nhs-transformation-directorate_nhsdigitrials-clinicalresearch-healthcare-activity-7302360165935140866-ZQHG title "Transforming clinical trial recruitment"

Did you see the EOI has opened a new tranche of trials to recruit with NHS DigiTrials?

You'll know someone with a trial that should explore this.

Apply now: lnkd.in/eiczmNpD

#NHSDigiTrials #ClinicalResearch #Healthcare #Innovation

1 year ago 4 2 1 0
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Plasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer This randomized clinical trial explores whether hormone intensification at start of androgen deprivation therapy alters selection of androgen receptor (AR) gene alterations within the gene body and/or...

Latest from #STAMPEDE - intensified AR targeting drives increased prevalence of AR mutations at progression compared to monotherapy patient samples jamanetwork.com/journals/jam...

1 year ago 2 2 0 0

Well done @timpmorris.bsky.social ! Brilliant to see this made available.

And let's hope StataCorp feel suitably and constructively provoked.

1 year ago 0 0 1 0
A vanilla KMunicate-style Kaplan–Meier graph from {kmunicate}. Key is the extended risk table showing the status of participants over time.

A vanilla KMunicate-style Kaplan–Meier graph from {kmunicate}. Key is the extended risk table showing the status of participants over time.

Stata users: if you want to make ‘kmunicate’-style Kaplan–Meier graphs, I’ve just released a Stata package on GitHub.

To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/

1 year ago 34 15 3 1

Sorry to link out to LinkedIn and Twitter.
None of the originators seem to have accounts here.

1 year ago 1 0 0 0

1=Absolutely delighted to one of HDR UK's inaugural Honorary Fellows

2=Looking forward to launch of Sudlow Review on UK Health Data Friday AM. If not in the room, watch the livestream

3=Enhanced Gateway will help unlock power of NHS data for research through the NHS Research SDE Network

1 year ago 2 0 0 0
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3 things that are on my mind:

▶️1 = HDR UK Honorary Fellows
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...

▶️2 = Sudlow Review
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...

▶️3 = Enhanced Health Data Research Gateway
www.linkedin.com/posts/nhs-tr... or x.com/NHSDigital/s...

1 year ago 2 0 3 0
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If you are missing (or sad about having missed) #ICTMC2024 from last week or #HDUG from this week, now's a good time to grab a cup of tea & read my first blog since joining NHS England Transformation Directorate's Data for R&D Programme. Here's a handy link: digital.nhs.uk/blog/data-po...

1 year ago 4 0 0 0
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***JOB ALERT***
I'm sure many of my #clinicaltrials colleagues in #industry and #academia will be interested in this advert for the Head of Data Operations for #DigiTrials at NHS England.

Link at beta.jobs.nhs.uk/candidate/jo...
Tight deadline (Sunday 06oct2024) just after #ICTMC2024.

1 year ago 6 7 0 1

Absolutely agree. That word stops my ability to take in anything else that person is saying around that time.

2 years ago 2 0 0 0