Conclusions:
🔵Acceptably low primary emergence rates
🔵Lower toxicity with INO radiotherapy
🔵No OS difference vs MUC
🔵INO may be a feasible alternative in modern practice
www.redjournal.org/article/S036...
Survival Data (see paper for full data, and sub-group analysis)
5-yr OS was similar between INO and MUC RT groups, 82% and 80%.
Death from other causes (not HNSCUP) was higher in MUC RT cohort (p=0.003).
Primary site emergence was rare, occurring in only 3/195 patients (1.5%)
Treatment and toxicity:
🔵RT dose/fractionation differed notably, with MUC receiving higher-dose schedules.
🔵Acute feeding-tube use was higher in MUC (33% vs 11%, p<0.001).
🔵NTCP for grade ≥2 xerostomia at 6 months was significantly higher in MUC group
Study Design:
Retrospective observational multi-centre study
18 UK cancer centres
Outcomes of interest: OS, emergence of primary site, disease relapse/recurrence, toxicity, and enteral feeding rates.
Study Aims:
🔵The aim of the study was to directly compare involved neck only (INO) RT versus bilateral neck and/or mucosal irradiation in patients with unilateral HNSCCUP.
Background:
🔵Management of HNSCCUP remains controversial, particularly regarding the optimal RT strategy, as traditional approaches have favoured comprehensive irradiation of bilateral neck and mucosal sites to minimize the risk of missing an occult primary.
NOTCH publication out now in @ijrobp.bsky.social !
Involved neck only (INO) vs mucosal radiotherapy (MUC) for HNSCCUP
INO RT for unilateral HNSCCUP offers similar 5-yr survival and disease control as MUC, and lower rates of enteral feeding
www.redjournal.org/article/S036...
📌 Leadership opportunity for clinical oncology trainees: NOTCH is recruiting a Vice-Chair (Chair-Elect) for January start, leading to Chair role after one year.
ST3+ eligible, committee experience preferred.
📧 Send EOI: uk.notch@nhs.net
🗓 Deadline: 12 Nov
#TraineeResearch #OncologyLeadership
Attention ST3+ oncology trainees!
We’re seeking an Events Lead to steer our events strategy, partner with DATA-CAN on advancing trainee research training, and bring new ideas to the table for collaborative events.
📩 To apply: send an EOI to uk.notch@nhs.net by 12 November
Abstract submission link: shorturl.at/zmz4X
Eventbrite registration: shorturl.at/cyYvK
More information: www.cruk.cam.ac.uk/seminars/cam...
🚨 Call for Abstracts!
🧠 Cambridge Head & Neck Cancer Symposium 2025
📍 25 Sept @ CRUK Cambridge Institute
🗓️ Submit abstracts by: 1 Sept 2025
✅ Submit via google form (link below) or email: thoracic@cancer.cam.ac.uk
🎟️ Don’t forget to register on Eventbrite! (link below)
Oncology Research Opportunity:
The applications for the @CR_UK City of London Centre Clinical Research Training Fellowships are now open!
Eligibility: medical degree, active GMC registration, dry or wet lab experience
Deadline: 5th November
Link: www.colcc.ac.uk/clinical-res...
Project Update: REAL-SAIF
Our retrospective study on 1L ICI therapy in advanced NSCLC (REAL-SAIF) is well underway!🇬🇧
32 centres have confirmed their participation across the UK - with representation from most cancer alliances 💪
Thank you to all our members for their ongoing efforts.
We would like to promote the @RCRadiologists Clinical Oncology Academic Day, taking place in November.
A great opportunity to connect with others, and to learn about the latest developments in clinical oncology research 🧬🧪
See you at the RCR! Sign up details below 👋
tinyurl.com/5n6haazw
Have you got an idea for an prospective or retrospective cancer study? Want to take it national?
Submit your project proposal form before 28th July for the next round of consideration ✍️
Submit your completed forms via email at: uk.notch@nhs.net
We look forward to reviewing your project proposals!
Our colleagues @RCRadiologists are hosting a free webinar for aspiring clinical oncologists navigating the specialty training and recruitment process!
Title: A Career in Clinical Oncology
Date: Tuesday 1st July 2025
Time: 5:15pm – 6:30pm
Register below👇and spread the word! 👋
That’s a wrap for #NOTCH2025 our 5th Annual Research Symposium!
Thank you to all of our delegates, sponsors, and speakers for providing education and inspiration for all current and future oncology researchers! 💫
We look forward to hosting you again next year! 🥳
#NOTCH2025
A value-packed keynote talk from Professor Wardley, Chair of Association of Cancer Physicians (ACP) sharing over 30 years of experience in medical oncology
💡 The ACP remains a pillar of support for medical oncology trainees to help shape future leaders in the field 🌟
#NOTCH2025
✅ Quality Assurance is key in clinical trials, yet often overlooked! Dr. Sarah Gwynne SW Wales Cancer Centre (@rttqa.bsky.social) delivered an outstanding session on RT QA in the SCOPE trial
A fantastic deep dive into an essential aspect of oncology research 🎯
An insightful session on clinical trials by Professor Greystoke @newcastleuni.bsky.social
🌍🔬
Excellent discussion on managing trials in both commercial and academic settings, with a focus on the CONCORDE platform trial in NSCLC 🧬🩻
Day 2 of the 5th Annual NOTCH Research Symposium is underway! 🙌🏽
We will shortly announce our abstract prize winners 🏆 and host a series of workshops 📚
A stellar talk delivered at #NOTCH2025 by Tom Roques the Vice President, Clinical Oncology at the Royal College of Radiologists 🩻
The RCR remains committed to supporting oncology residents throughout their training and promoting oncology at the national policy level 💡
a TOUR-de-force by our Chair Karin Purshouse ✨🙌🏽
Karin presented our previous and current projects at #NOTCH2025, including the TOURISM study that was published in BMJ Open this year 📝
Register your interests for our projects here: www.uknotch.com/projects
Debra Montague, Chair of ALK+ UK, is speaking today at the @notchonctrainees.bsky.social Research Symposium—sharing her story, the growth of ALK+ UK, and why earlier diagnosis and better support for people with ALK+ #lungcancer really matters. #LCSM
🫁 ALK-Positive Lung Cancer – Debra Montague provided insight on the advancements and challenges that ALK positive patients face
❤️ Cardio-Oncology – Dr. Gerard Walls explained the crucial intersection of cancer treatment and cardiovascular health.
3/3
💼 Working with Industry – Dr. Saif Ahmad discussed collaborations in oncology, offering a behind-the-scenes look at bridging academic research with industry to drive innovation.
2/3
Inspiring Discussions Taking Place at #NOTCH2025 ! 🎗️
🔬 Cancer Survivorship – Prof. Skinner shared insights on long-term follow-up care for childhood cancer survivors, highlighting the evolving needs of this growing patient population.
1/3
Thank you to all delegates who have already registered. We are here to welcome you throughout the day!
Say hello to our Board Members Dharrsshini and Mariam 👋
#NOTCH2025
All systems go here at the 5th Annual Research Symposium 🚀🧬
We look forward to welcoming all of our speakers, delegates, and sponsors at #NOTCH2025
