Endpoint Arena bills itself as a prediction market for clinical trials.

How do human/AI predictions influence recruitment, early termination, disinvestment?

Can we still call it equipoise if a trial is badmouthed?

Will there be insider training like on Polymarket?

endpointarena.com/

Inside the £64bn pharma deal that could cost more lives than Covid With the NHS on its knees, the UK has struck a secretive new drugs deal. But how was it made – and what will it really cost?

Inside the £64bn pharma deal that could cost more lives than Covid

www.thebureauinvesti...

HT: Mark Sculpher

At #SHMConverge26?

Today's Updates in Hospital Medicine covers the last year.
Our book covers the last 20+ years - the evidence beneath the updates.

Free chapter (DOSE trial) until April 16: academic.oup.com/boo...

30% discount AUFLY30: academic.oup.com/

Opinion | How Can America Be So Miserable When It’s So Rich? The just resentments of a shrinking middle class.

Economists often look to the 🇺🇸.
Famously, when America sneezes, the world catches a cold.
What's going on in the country in terms of people's attitudes towards wealth?
These days, I only travel to the 🇺🇸 x 1-2/year, but found this column worthwhile.

The editing team (before years of transatlantic Zoom calls) 🤓

Grateful to every contributor who made this educational product happen 🙏

50 Studies Every Hospitalist Should Know wouldn't exist without its contributors - hospitalists, cardiologists, ID specialists, intensivists who distilled the trials that shape their bedside decisions.

This book is theirs.

Grateful to every one of them.

www.amazon.com/Studies-Ever...

Physical copy of 50 Studies Every Hospitalist Should Know arrived..

After years of transatlantic editing with Jeff & Kathy -starting from when we met at @massgeneralbrigham.bsky.social- the paperback is a different feeling!

Now available from @oxunipress.bsky.social: www.amazon.com/Studies-Ever...

When someone begins their sentence with "Strangely enough, ..." - it's often ends up not being that far-fetched...

#491 – OpenClaw: The Viral AI Agent that Broke the Internet – Peter Steinberger Podcast Episode · Lex Fridman Podcast · 12 February · 1 sec

I'm not (wasn't?) a coder - but I thoroughly enjoyed Lex Fridman's interview with Peter Steinberger!

Conan O’Brien on What Can Go Wrong at the Oscars Podcast Episode · The New Yorker Radio Hour · February 20 · 31m

I laughed out loud during this interview with Conan O'Brien

America Is Entering a Dangerous Moment — with Timothy Snyder Podcast Episode · The Prof G Pod with Scott Galloway · January 29 · 1h 2m

Here's an interesting interview with Timothy Snyder podcasts.apple.com/us/podcast/a...

ChatGPT Health under-triaged 52% of true emergencies and overtriaged 65% of "home" cases in a new Nature Medicine study. Triage is judgment, not just language per se. "This is a patient safety issue." www.nature.com/artic...

thanks for doing the starter pack!!!

Great talk by @dsquintana.bsky.social on social media for academics

Slides: osf.io/jqavy/files/...

Here

Exploratory biomarkers for oxaliplatin-induced nivolumab responsiveness in metastatic microsatellite-stable colorectal cancer British Journal of Cancer - Exploratory biomarkers for oxaliplatin-induced nivolumab responsiveness in metastatic microsatellite-stable colorectal cancer

New in the British Journal of Cancer: post hoc analysis of METIMMOX - high TMB or BRAF-V600E may identify nivolumab responders in MSS metastatic CRC.

Hypothesis-generating,
PFS only,
prognostic vs. predictive unresolved.
But a signal worth pursuing. 🧬

Race for AI is making Hindenburg-style disaster ‘a real risk’, says leading expert Prof Michael Wooldridge says scenario such as deadly self-driving car update or AI hack could destroy global interest

"This is not the AI we were promised." Prof Michael Wooldridge warns the breakneck AI race risks a Hindenburg-style catastrophe.
​
In 2026, IPOs/valuations seem to trump safety. Time to rebalance incentives before markets brutally enforce it.

The role of comorbidities in the associations between air pollution and Alzheimer’s disease: A national cohort study in the American Medicare population In a national cohort study of US Medicare beneficiaries, Deng and colleagues investigate the association between air pollution and Alzheimer's Disease.

28M Medicare patients, 18 years, PM2.5 → Alzheimer's risk. Effect "direct"—not through hypertension or stroke. Interesting. But ZIP-code SES adjustment + ICD-code AD diagnosis = residual confounding still very much alive.

Moltbook: 1.5M AI agents posting on a social network where humans just watch. Karpathy calls it "sci-fi takeoff-adjacent." Real tech capability or elaborate performance art? Probably both. Worth watching either way. 🦞🤖

Update: Now live on Kindle! 📱

Seeing "50 Studies Every Hospitalist Should Know" on Amazon feels surreal after months of work with brilliant contributors worldwide.

Paperback soon | www.amazon.com/Studies-Ever...

Just published: our roadmap for making innovative therapies affordable & accessible across Europe. Proud to be part of the ASCERTAIN team! #HEOR #HealthEconomics
www.sciencedirect.co...

Holistic evaluation of large language models for medical tasks with MedHELM Nature Medicine - MedHELM, an extensible evaluation framework including a new taxonomy for classifying medical tasks and a benchmark of many datasets across these categories, enables the evaluation...

New framework for evaluating medical LLMs published in Nature Medicine!

My take: Interesting standardization effort, but may be too general for real-world use & models evaluated are already outdated...

Fascinating essay uses ecological metaphors for academia. Having worked across 3 continents, Australia was most neoliberal (high metrics, high pay). But academia needs what metrics can't measure: time to think, boredom, permission to fail.

Speed up prior authorization reviews with Claude Claude helps utilization management teams complete initial prior auth reviews in minutes—work that typically takes hours of manual cross-referencing across policies, databases, and documentation, which can slow patients’ access to care. Watch how Claude validates provider credentials in the NPI Reg

Claude reviews a prior authorization request!

Is this good (speedy, less costly) or bad (AI arms race on payor and provider sides)?

Draft clinical trial protocols with Claude Claude helps clinical development teams draft Phase 2 protocols in under an hour—work that typically takes days of cross-referencing FDA guidelines, competitor trials, and internal templates. Watch how Claude digests preclinical data, takes relevant FDA and NIH requirements into account, searches Cl

Claude write a clinical trial protocol with its new healthcare/life sciences connectors and skills.

Is this good (speeds up trial planning) or bad (deskills P.I.s, more "cookie cutter" trials, not enough critical review in some cases)?

New 13-year study of 4K Norwegian pregnancies with RA: medication use during pregnancy up 31%→50% (2008-18), driven by TNF inhibitors. But gaps remain in preconception care.

w/ Eun-Young Choi, Marleen van Gelder, 오인선In-Sun Oh, and Hedvig Marie Nordeng
www.sciencedirect.co...

SMDM 2026 social event announced: Oslo City Hall in the Nobel Peace Prize Reception Hall. Bread and Games subsequently.

smdm.org/civicrm/eve...

This book was started by the wonderful Hugo Torres and Priyank Jain and the series by Michael Hochman.

Great post in Bob Wachter's new substack:

Will A.I. kill health care jobs, too (and not just coders', Uber drivers', or those in admin, manufacturing, retail ...)?

Bob's conclusion: yes, but it may not be the clinical jobs!

CDI? Compliance? More so!

substack.com/inbox/p...

New in Lancet Oncol: Which occupations have the highest cancer deaths?

For ♂s it was the rather broad construction/extraction category, for ♀s the transportation one.

Statisticians, chiropractors, & funeral directors had the highest breast cancer risk

http://bit.ly/4aZLP9c