We should also have one for Canadian scientists in US. Stronger together regardless of borders. You know, the way it was before all this 51st state rhetoric. For the record, I love my American colleagues (that’s why I moved here) and think the current situation is an insult to us all.

Absolutely beautiful work.

Thanks to @droch.bsky.social for correction - this should be Novo Nordisk not Roche

Thanks Julien. I questioned this after I hit send and was going to try to edit.

But I think your statement only applies if academia generates a compound because a process or pathway cannot be patented and any returns on compound go to university not NIH. I was thinking of what happens with Roche in Denmark but I am not versed in roadblocks here in US

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

Begging the question of why it is not mandated that a return of a percentage of profits on said drugs go back to fund NIH research.

In-cell architecture of the mitochondrial respiratory chain Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...

Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...

Congratulations Kevin!

Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex - Communications Biology In order to assess the effects of aging on the autoregulation of TAR DNA-binding protein 43 (TDP-43) and the potential effects of this on the role of TDP-43 in Amyotrophic Lateral Sclerosis (ALS), Koi...

I wonder how specific this may be to ALS? Aging also causes Tdp43 dysfunction (risk of ALS increases w age) www.nature.com/articles/s42... so perhaps this is more about importance of CoxIV to motoneuron survival than ALS per se?

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

Yet another report on the economic value of NIH investments The indiscriminate and large cuts are illogical and harmful I am angry www.forbes.com/sites/michae...

Please congratulate Casper and rest of your team for me!

Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise‐dependent manner Muscle biopsies were taken from males and females differing in age and exercise habits. Mononucleated cells were isolated and purified into muscle stem cells (MuSC) and muscle fibroblasts (FIB). Neur...

Fascinating new work from @abigailmackey1.bsky.social onlinelibrary.wiley.com/doi/full/10....

Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians - PubMed Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into...

New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/

Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...

... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging:

doi.org/10.1038/s415...

3/3

Body composition alterations in patients with lung cancer | American Journal of Physiology-Cell Physiology | American Physiological Society Most patients with lung cancer experience cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting. Knowledge of body composition changes in patients is limited, however, because...

Our new review on longitudinal body comp in lung cancer is now in print!
journals.physiology.org/doi/full/10....

Just drop me a line, Vincent! Gilles knows how to reach me.

‘I really wanted something to happen.’ The students behind the Stand Up for Science protests New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies

Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals.

So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD

Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 - Nature We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, ...

www.nature.com/articles/s41...

Rare genetic disorder treated in womb for the first time The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.

https://go.nature.com/41a7Zzj

A primer on global molecular responses to exercise in skeletal muscle: Omics in focus Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level. Over the past 2 decades, tran…

@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth #myoblue www.sciencedirect.com/science/arti...

We should try to partner with MoTrPAc to get comparator data on younger participants. Just a thought.

Sounds like a plan! I think an important component will be to address heterogeneity. My sense is that some will be responsive and others not so much.

It is this period when preservation of oxphos might become the cause of greater voluntary exercise rather than the result. Let’s call it a hypothesis 😊

Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity - PubMed The purpose of this study was to investigate whole muscle and single muscle fiber adaptations in very old men in response to progressive resistance training (PRT). Six healthy independently living old...

Thanks for the very thoughtful reply, Gilles! I have no issue about exercise increasing oxphos except to make the point that I am not aware of any data addressing those >75 y, a time when the anabolic response to strength training is lost. pubmed.ncbi.nlm.nih.gov/18448613/

Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...

When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️

www.cell.com/cell-reports...

Great work Gilles and team! To what degree do you think those who remain active with aging do so because they maintain mitochondrial oxphos capacity, rather than maintained oxphos being the outcome of being active?

Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS Ruggieri et al. developed a spatial transcriptomics dataset of skeletal muscle from the SOD1G93A ALS mouse model. Their findings highlight polyamine metabolism’s role in muscle fiber vulnerability, sh...

Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
www.cell.com/cell-reports...

Mitofusin 2 displays fusion-independent roles in proteostasis surveillance - Nature Communications Mitochondria influence cellular proteostasis, though the proteins that mediate this role are not well described. Here they show that the mitochondrial protein MFN2 interacts with the proteasome and wi...

www.nature.com/articles/s41...

Skeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit Remodeling This review explores the intricate processes of motor unit remodeling with a specific focus on the influence of reactive oxygen species (ROS) and oxid…

Skeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit Remodeling
www.sciencedirect.com/science/arti...