Miki Ebisuya, TU Dresden EMBL
Mukund Thattai, NCBS
Nicoletta Petridou, EMBL
Paul François, McGill
Rashmi Priya, Crick
Sara Wickström, MPI
Takashi Hiiragi, Hubrecht Institute
Wendell Lim, UCSF
Yanlan Mao, MRC
Jennifer A. Lewis, Harvard
Jesse Veenvliet, MPI
Jun Allard, UCI
Karen Alim, MPI
L. (Maha) Mahadevan, Harvard
Matthias Lutolf, EPFL
Michael Elowitz, Caltech
Miguel L. Concha, Universidad de Chile
Still some doubts 😊here the list of speakers
Alan Lowe, CZI
Alex Schier, Biozentrum
Allon Klein, Harvard
Amy Shyer, The Rockefeller
Arthur Lander, UCI
Christina Theodoris, Gladstone
Dana Pe’er, MSKCC
Ewa Paluch, Cambridge
Giovanni D’Angelo, EPFL
James Briscoe, Crick
The deadline to apply for the Lake Conference on Modeling Life from Cells to Tissues is just few weeks away!
Apply to attend by December 12:
alleninstitute.org/events/aics-...
Modeling Life from Cells to Tissues
Emergence and Self-organisation across biological scales! I hope you are ready for next year conference! It will be an incredible event April 20-22 2026. The first of many #LakeConference organised by
@ehannezo.bsky.social @alleninstitute.org and James Sharpe @embl.org
The last day of lectures at #LISH25 starts with Gustavo Medeiros presenting applications of light sheet microscopy to #organoid research. @priscaliberali.bsky.social lab. Gustavo is a physicist and a creative artist and the walk-up song delivers that message. Video in thread.
🚨We're hiring! Join a global team at the @priscaliberali.bsky.social lab & the @alleninstitute.org to build cutting-edge image analysis workflows for complex biological datasets, including light-sheet microscopy images. Apply at: www.fmi.ch/education-ca...
We're seeking a Research Associate in stem cell biology to join a global, interdisciplinary team investigating organoids and tissue organization. This unique role is part of a collaboration between the @priscaliberali.bsky.social lab & the @alleninstitute.org. Apply at: www.fmi.ch/education-ca...
In @naturephysics.bsky.social, researchers from @priscaliberali.bsky.social's lab and @ehannezo.bsky.social's group reveal how intestinal organoids form crypts, key to gut regeneration and stability. Their work could impact tissue engineering and regenerative medicine. www.fmi.ch/news-events/...
Amazing work Irene and Tomo!
Super retreat! And don’t miss the paper on robustness in crypt morphogenesis 🤩
Fun group retreat in the Austrian alps with @priscaliberali.bsky.social! And perfect time to celebrate our new joint paper (from Shi-Lei Xue & Qiutan Yang) out on how mechanochemical bistability confers robustness to intestinal organoids! www.nature.com/articles/s41... - see 🧵! (1/n)
Don’t forget to apply! This is an amazing opportunity!
This shows that transient heterogeneity establishes a regulatory framework essential for proper intestinal regeneration and could be a general principle underlying a wide range of regenerative processes.
And validated in vivo!
We developed mathematical models showing how YAP1 and FOXA1 drive bistable states, allowing cells to "lock in" their fates. A feedback loop ensures long-term pattern stability and confers memory to the system.
And FOXA1 role is essential to exit a default state of differentiation.
YAP1 heterogeneity primes secretory progenitor cells, setting the stage for robust patterning. This involves chromatin remodelling, creating a favourable environment for FOXA1, a critical transcription factor.
When tissue density hits a critical level, YAP1 activity becomes heterogeneously inactivated. This cell-to-cell variability is essential for triggering the first cell fate decisions via chromatic remodelling and Delta-Notch signalling.
And the movie!
We also made a Yap activity fluorescent reporter organoid line to look into the dynamics at the tissue scales!
Using in vitro organoids and in vivo mouse models, we uncovered that mechanosensor YAP1 acts as a molecular "pre-patterner" cue during regeneration.
Amazing work @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social
Tissue regeneration is driven by cells transitioning from homogenous regenerative cells to a patterned crypt. But actually cell-to-cell variability plays a super important role for the return to homeostasis!
A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...
Join us at FMI as a Junior Group Leader! A unique opportunity to set up your lab in a vibrant international research institute with world-class research groups and facilities, generous core funding, a collegial and inclusive culture - and great colleagues 🤓!
We have a new opening! Amazing environment colleagues and facility! Join us!
Do you want to know how tissue is coordinated across space and time? Don’t miss Laura’s talk!
