Just flagging up this conference that I'm helping with.

There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.

Energy deficiency selects crowded live epithelial cells for extrusion - Nature Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.

Cells in crowded epithelia aren’t chosen at random for extrusion & death — energy levels decide who goes. Great work from Jody Rosenblatt and team shows cells with low energy stay depolarized, triggering K⁺ and Cl⁻ channels, lose water, shrink, and are extruded alive. www.nature.com/articles/s41...

I know right, why don’t you write Fiona’s group at King’s College, they must have it.

Not sure if this works for you, Jon

Normal Human Epidermal Keratinocytes (NHEK) Primary Human Keratinocytes isolated from the epidermis of juvenile foreskin or adult skin from single or pooled donors.

promocell.com/us_en/normal...

Thanks Jon, for sharing our study, which reports a major advance in prostate cancer. This iPROS model overcoming a long-standing barrier of lacking physiologically relevant cancer development models. Importantly, the system models oncogenic plasticity in the presence of BRCA2 genetic-risk variants.