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Posts by Tim

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Cell Bio 2023-An ASCB|EMBO Meeting Network, learn, and collaborate with top cell biologists from around the globe.

🚨Hear, hear, fellow microbial cell biologists!🚨
🦠 Bacterial and Archaeal Cell Biology will be represented again at this year’s CELL BIO (ASCB-EMBO) meeting! The deadline to be considered for a talk in our Minisymposium is June 9. Help us spread the word!
www.ascb.org/cellbio2026/

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What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~
www.biorxiv.org/content/10.6...

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LSA Immunology Collection 2026 Life Science Alliance publishes novel findings of exceptional quality on immunology, immune-related diseases, immunotherapies, and cellular and structural biology related to immune cells. We are proud...

Coming to the annual @aai.org meeting in Boston?? Find me looking around for amazing new science.

Check out the excellent immunology we publish at @lsajournal.org in our Special Collection just out!!

www.life-science-alliance.org/content/lsa-...

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Another delightful visit to my alma mater @ucscscience.bsky.social

Thanks to @needhibhalla.bsky.social and many others for exciting + important convo.

Most of all thanks to students who came to my talk w SO MANY good questions about careers + publishing.

Until next time!

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TaoChongBao: a large-scale C. elegans missense variant database bridging worm and human genomes We generated and sequenced 12,069 viable Caenorhabditis elegans strains produced by ethyl methanesulfonate mutagenesis, identifying 20,315,536 variants, including 541,102 unique missense mutations acr...

Check out the largest collection of C elegans missense variants to date:
- 12k unique & viable strains sequenced
- 20 million variants
- 21k genes
- integrated database with ClinVar for translation to humans

Out now at @lsajournal.org

www.life-science-alliance.org/content/9/6/...

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When do PIs, especially with teaching commitments, ever find time to read papers to keep up with the field? Do you set aside specific times of the week, use the daily commute on bus/train, or have come up with some other approach?

Asking for a friend...

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I got to see a former trainee defend her thesis @rockefeller.edu!

Marwa Saad worked with me at MIT during my postdoc and gave me this fabulous mug (still have it!)

Then we both ended up at Rockefeller! She was a grad student w with @danmucida.bsky.social and I’m here at @rupress.org

Congrats!!

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EMBO Press co-evolves with molecular ecology and evolutionary biology - The EMBO Journal The EMBO Journal - Molecular ecology and evolution are central to understanding how biological systems function, interact, and diversify. A special issue of this journal reflects the growing...

Read their nice introduction to this shift at @embojournal.org
doi.org/10.1038/s443...

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Important pivot underway by my colleagues @embopress.org to embrace evolutionary biology, diverse species, and non-reductionist approaches to biological systems.

Bravo!

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Why did Nature expand? It is unacceptable that an author might find a non-Nature journal as a fit for their work:

"Awe noticed that there is growth in some fields that we don’t think we can support effectively within the range of journals that we currently have."
-Executive VP, Journals

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Negative Data LSA is proud to be a home for studies that report negative or inconclusive results, serving our mission of lowering barriers to publication for rigorous findings of immediate value to the field. The a...

Find my editorial here, along with a special collection of really solid papers at @lsajournal.org that showcase the importance of negative data:

www.life-science-alliance.org/content/nega...

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Gould's essay is exquisite and was taken up admirably by Bowerman (who corresponded with Gould, quoted in his piece).

Both provided me with fantastic examples outside cell biology and biomedicine that perfectly highlight the universality of this issue:

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A few years earlier, Gould wrote Cordelia's Dilemma to discuss why scientists decide that some data are not interesting.

While paleontologists scoured the fossil record for evidence of evolution, the non-change (stasis) they often observed was explicitly uninteresting according to Gould:

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Writing my recent editorial was secretly just an excuse to read a bunch of Stephen Jay Gould. I was led there by Howard Browman in his editorial.

Browman frames question of negative data as a deeply philosophical issue of what motivates scientists to communicate their findings.

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the most annoying shift in my academic career

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Thanks for sharing Richard! You can see why I wanted to quote you here.

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Really cool work here!! Congrats @emery-lab.bsky.social

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Negative Data LSA is proud to be a home for studies that report negative or inconclusive results, serving our mission of lowering barriers to publication for rigorous findings of immediate value to the field. The a...

Editorial here:
www.life-science-alliance.org/content/9/3/...

And peruse some fantastic studies reporting negative results, including important refutations, here:
www.life-science-alliance.org/content/nega...

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Editorial by me, in our March issue!

Negative results are a thorny issue in essentially all fields of scientific research, and deserve a renewed look by authors and editors 👇

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It’s finally out! Together with @embopress.org and
@reviewcommons.org, we conducted a structured side-by-side comparison of human peer review and our AI scientific review (see thread 👇👇👇🔥).

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Returning to this to emphasize that NIH action/inaction is preventing funds from getting to researchers. Important to note the difference between legislative budget actions and executive disbursement actions. graph via @deniswirtz.bsky.social

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Required reading, folks 👇

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🎉🎉🎉

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CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...

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Actin waves guide an outward movement of microclusters in the lymphocyte immunological synapse - EMBO Reports The lymphocyte immune response begins with antigen recognition on antigen-presenting cells, leading to the formation of the immunological synapse—a specialized interface for biochemical and biophysica...

doi.org/10.1038/s443...

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Congrats @sudha-kumari.bsky.social on this nice paper out in @emboreports.org 🥳

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This is also something that NIH Director Bhattacharya loves to trumpet (as if no other NIH officials before him recognized this problem...)

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Yes absolutely

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It seems republicans under Trump are continuing this trend? Overall increased NIH budget and very minor cuts to NSF and CDC.

But of course that does not account for grant awards delayed or prior grants cancelled by the current HHS/NIH...

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