The Yak-52 first flew in 1976.

These Ukrainian pilots and crew blasting drone out of the sky from open cockpits is one of the most bad-assed things I’ve ever seen.

I am just now catching up on the fact that the FDA was demanding Uniqure do sham brain surgeries (from what I can tell, comprising simulated burr holes and 10-12 hours of anesthesia) in their placebo arm for their Huntington's therapeutic, and I'm absolutely floored that this was a serious demand.

Are you finished with the proposal?

I had a hunch based on the bolding pattern that this was gpt-5-generated, and sure enough, AI wrote the announcement:

My quote of the day

Courage is the most important of all the virtues, because without courage you can't practice any other virtue consistently. You can practice any virtue erratically, but nothing consistently without courage.

Maya Angelou

The expression “making time” is strange. Time cannot be manufactured. It can only taken from one thing and given to other.

Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404

Ok. Didn’t know that was a thing. But I don’t judge.

A map of the US with the states the republican senators are from marked in red and states the democratic senators are from marked in blue: Senator Susan Collins (Republican - Maine) Senator Mitch McConnell(Republican - Kentucky) Senator Lisa Murkowski(Republican - Alaska) Senator Lindsey Graham(Republican - South Carolina) Senator Jerry Moran(Republican - Kansas) Senator John Hoeven(Republican - North Dakota) Senator John Boozman(Republican - Arkansas) Senator Shelley Moore Capito(Republican - West Virginia) Senator John Kennedy(Republican - Louisiana) Senator Cindy Hyde-Smith(Republican - Mississippi) Senator Bill Hagerty(Republican - Tennessee) Senator Katie Britt(Republican - Alabama) Senator Markwayne Mullin(Republican - Oklahoma) Senator Deb Fischer(Republican - Nebraska) Senator Mike Rounds(Republican - South Dakota) Patty Murray(Democrat - Washington) Richard Durbin(Democrat - Illinois) Jack Reed(Democrat - Rhode Island) Jeanne Shaheen(Democrat - New Hampshire) Jeff Merkley(Democrat - Oregon) Christopher Coons(Democrat - Delaware) Brian Schatz(Democrat - Hawaii) Tammy Baldwin(Democrat - Wisconsin) Chris Murphy(Democrat - Connecticut) Chris Van Hollen(Democrat - Maryland) Martin Heinrich(Democrat - New Mexico) Gary Peters(Democrat - Michigan) Kirsten Gillibrand(Democrat - New York) Jon Ossoff(Democrat - Georgia)

Are you from one of these states? Then we need your help to save American science!

The Senate Appropriations Committee will be marking up the President's Budget Request for science on Wednesday. People have been saying the proposed cuts "decimated" US science, but that's wrong: they are apocalyptic

Today is the last day to submit public comments on Schedule F, which is essentially designed to politicize the Civil Service. Here is the letter that I just submitted:

If universities do not unite on this, we will all fall. The entire country will suffer.

They will not stop at Harvard and Columbia. They are coming for ALL of higher education. Every single center of higher education will be targeted.

This is what authoritarians do. Again, and again, and again.

From hundreds of terminated grants in biomedicine to selective prosecutions to organizational overhauls at the nation's science funding agencies, today's news reports salvo after salvo from a Republican administration dead set on destroying higher education—and with it, US leadership in technology.

All 4 of my NIH research grants are terminated. These were grants on MDR-TB treatment & strategies for supporting adolescents living w/ HIV. This is a massive waste of resources. I am heartbroken for my Harvard team, my partners in Peru, the next generation of scientists & our country. Shame.

FROM @reuters.com: The Trump administration has said addressing autism is one of its top health priorities. Records show it has also halted about a quarter of NIH's research funding related to autism.

www.reuters.com/business/hea...

Antibiotic research at Harvard lab threatened by federal funding cuts Microbiologist Michael Baym studies antibiotic resistance at Harvard Medical School. He lost millions in federal funding this week.

"I'm still in shock. I know that there have been political issues around Harvard in recent weeks, but antibiotic resistance isn't one of them." My conversation with Harvard microbiologist @baym.lol, one of many researchers there who just lost millions in fed. grants. www.wbur.org/news/2025/05...

A Path Forward to Save American Bio-Medical Research Over the past four months, I’ve spoken to dozens of biomedical researchers...

"The future of biomedical research [amounts to] a race to see whether the biomedical research community can mobilize politically, access that vast but latent political power, before the White House can do enough sustained damage to make the whole question moot." talkingpointsmemo.com/edblog/a-pat...

What losing billions in federal grants means for universities, and the nation The Trump administration has so far frozen about $11 billion in research funding. University leaders say no other source can fill the void.

What cutting science and biomedical grants mean for the nation...

www.npr.org/2025/04/25/n...

A scientific Boston massacre.

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F

#ASGCT2025 #MedSky @asgct.bsky.social

At the end of this summer, the future of U.S. science and research will be decided.

From weather alerts to cancer breakthroughs, science shapes every part of our lives.
We need everyone in this fight.

The Summer Fight for Science starts now. Are you in?

The fight starts here: bit.ly/4ddiuqU

A screenshot of the termination notice showing "Outstanding Investigator Grants"

A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

I am thinking a lot today about how heavy things feel in my world of faculty doing scientific research. There's the immediate chaos and panic about our ability to pay people and continue our research. But there's also a deeper grief at watching everything get bulldozed for no reason

I never imagined I would see something like this happen to federally funded research in the US. I am heartbroken for all the researchers whose grants have been terminated and devastated for all the patients whose current (and future) treatments are being impacted 🧪 💔

Current situation at Harvard Medical School for NIH grants view.u.hms.harvard.edu?qs=3ed8c01b9...

A graph with clusters gray curves showing NIH grant making for fiscal years 2015-2024 with a red curve showing slower grant making in fiscal year 2025.

Slow grant making continues. Here is a graph through May 1st.

2/n

the word alert is in a purple circle ALT: the word alert is in a purple circle

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

Many hundreds (perhaps up to 1000) of additional NIH grants appear to be have been terminated on Friday.

I have updated the data from the HHS TAGGS site (and converted it from a pdf to an Excel file) on the dashboard but many hundreds are still missing.

jeremymberg.github.io/jeremyberg.g...

Today I lost an NIH grant training clinicians to do research about intimate partner violence with perinatal women.

More women are murdered in the perinatal period than die of obstetric complications.

I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.