Single Cells Can Resolve Graded Stimuli By quantifying the information transmitted from receptor to ERK, the study shows that individual cells can resolve graded stimuli, transmitting over 2 bits of information even with brief, sparse input...

What if cellular signaling pathways work better than we thought? Previous experiments were population-level measurements, but using optogenetics, we can determine the information capacity of the ERK pathway for single cells.
Paper with @mirnakramar.bsky.social is out now! doi.org/10.1103/pyf8...

More Informative Together Than Apart The concurrent analysis of two measurements of a biochemical signaling network can provide more information than two separate probes of the datasets.

Scientists could obtain more information from two measurements of a biochemical network if they analyze them collectively, rather than sequentially. Story by me. Written for @physicsmagazine.bsky.social. physics.aps.org/articles/v16...