It would be nice to have an easy to use alternative to their software. We couldn't get it to work a few years ago because it needed more than 150GB of RAM for a WT dataset. It was storing most of the read information in memory at some point. We ended up cobbling something together with STAR solo.

Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes - Nature Communications Topoisomerases resolve topological DNA stress via double-strand breaks and are established targets of cancer chemotherapies. Here, the authors link genomic binding of TOP2B with localized mutational p...

⚠️New study: we mapped DNA-binding of topoisomerase TOP2B in cancer, uncovering surprising hotspots of DNA damage. TOP2B, normally essential for DNA stress relief, can act as a double-edged sword. co-led by @LiisUuskula @ChristianLee, out now @natcomms.nature.com www.nature.com/articles/s41... [1/7]

Repost the work-week crowd ;)

minimap2 adds support for short read spliced RNA-seq alignment! lh3.github.io/2025/04/18/s...

UHN's newest documentary—The Future of Transplant—shines a light on the historic accomplishments of @transplant-uhn.bsky.social, setting the stage for innovative breakthroughs transforming #transplant today! ✨🫁

Learn more about the legacy and people behind the discoveries ⬇️

RNA xkcd.com/3056

I made a starter pack for algorithmic genomics. It's certainly incomplete, but already has a ton of awesome peeps. Let me know if you know people I should add (with a focus on algorithms and data structures in genomics)

go.bsky.app/TRWCnZs