Brainstem GLP-1 neurons modulate physiological satiation and drive sustained weight loss in obese mice Glucagon-like peptide-1 receptor (GLP-1R) activation in the brain strongly reduces appetite, but most brain GLP-1Rs are not accessible for systemicall…

Our latest work published in Molecular Metabolism www.sciencedirect.com/science/arti...
a great team effort with @wanqingjiang.bsky.social, @ceciliaskoug.bsky.social, @drdanbrierley.bsky.social, @ccmnlondon.bsky.social, @uclnpp.bsky.social, @mkbholt.bsky.social and our collaborators at Cambridge.

Happy Holiday Season to all friends, colleagues, collaborators and competitors! May the GLP-1 field stay as exciting in 2026 as it was in 2025!

Brainstem GLP-1 neurons modulate physiological satiation and drive sustained weight loss in obese mice Glucagon-like peptide-1 receptor (GLP-1R) activation in the brain strongly reduces appetite, but most brain GLP-1Rs are not accessible for systemically administered GLP-1R agonists. Acute activation o...

We would like to share our findings of the physiological importance of brainstem GLP-1 neurons (also known as PPG or GCG neurons) and invite thoughts on this.
www.biorxiv.org/content/10.6...

Brain-Derived GLP-1—Understanding the Physiological Function and Anti-obesity Potential of Preproglucagon Neurons Abstract. Glucagon-like peptide-1 (GLP-1) is produced within the central nervous system (CNS) by preproglucagon (PPG) neurons. This brain-derived GLP-1, ra

Our latest thoughts on brain-derived GLP-1 are out in Endocrinology now.

academic.oup.com/endo/article...

Our brilliant PhD student Wanqing Jiang had her graduation ceremony last week! Big congratulations and all the best for a great future in Science!

Dr Cecilia Skoug presenting the latest mouse behaviour data from the Trapp lab at @theiups.bsky.social. Great presence from @ccmnlondon.bsky.social at a fantastic meeting!

Last conference for the year for me is IUPS 2025. Yesterday was the well-attended symposium ”GLP-1 Receptor Agonists - a Magic Bullet Beyond Diabetes and Obesity?” Chaired by Prof. Stefan Trapp @trapp-lab.bsky.social Maybe I’m
biased but a great symposium indeed! @ccmnlondon.bsky.social

Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain - Nature Metabolism A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors, and are used to image receptor binding activities in tissues and animals.

Interested in brain access for Tirzepatide-based drugs? Have a look at the fluorescent Tirzepatide analogue developed by Johannes Broichhagen and David Hodson @daveyboyhod.bsky.social‬ out now in Nature Metabolism www.nature.com/articles/s42.... Proud to contribute to this great multi-lab effort.

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

We are recruiting! If you are interested in working as a post-doctoral Research Fellow in the heart of London contributing to MRC-funded research into GLP-1 action within the brain, please look at this link and apply if interested: www.ucl.ac.uk/work-at-ucl/...

Great starter pack. Can I please be added?

The Trapp Lab has moved to BlueSky. No better way to start this than with a new paper.
We are excited to alert you to the latest study on the involvement of brain GLP-1 in stress responses led by our @CCMN_London and Trapp Lab
alumni @MKBHolt

Read the details at doi.org/10.1016/j.mo....