Super excited to share our latest work on RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection!

www.biorxiv.org/content/10.1...

RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection www.biorxiv.org/content/10.1101/2025.07....

RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection www.biorxiv.org/content/10.1101/2025.07....

A huge thank you to the American Cancer Society @americancancersoc.bsky.social for funding this work in our lab through a Research Scholar award!

This work was spearheaded by two amazing grad students, co-first authors Vikas Peddu & Alex Hill, with significant contributions from Sreelakshmi Velandi Maroli & Connor Mattingly, as well as our wonderful collaborators Joshua Gardner, Karen Miga, and Rebecca Fitzgerald!

Our study highlights the utility of our long-read sequencing-based RNA liquid biopsy approach for discovering and targeting early stages of disease with molecular precision.

Through our LOCATE-seq RNA liquid biopsy platform technology, we also discovered potential therapeutic targets, including metabolic, signaling, and immune checkpoint pathways, that are highly upregulated in both precancer and cancer patients.

Using these novel, unannotated cell-free RNAs, we built a custom transcriptome reference for quantification, feature selection, and machine learning to accurately classify both precancerous Barrett's esophagus with high-grade dysplasia and early-stage esophageal adenocarcinoma.

We leveraged the power of single-molecule, long-read sequencing of cell-free RNA using Oxford Nanopore Technologies' PromethION platform @nanoporetech.com to discover over 270,000 novel, intergenic cell-free RNAs.

Super excited to share our latest work on RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection!

www.biorxiv.org/content/10.1...

Happy to share our new work with @haognguyen on targeting mRNA translation of oncogenes by RNA structure remodeling with a small molecule zotatifin. Congrats to ⁦@DuyguKuzuoglu⁩ an amazing postdoc and all the authors and collaborators!

cell.com/cancer-cell/fu…

Register today for RNA 2025 - the 30th Annual Meeting of the RNA Society! This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27 - June 1.
www2.rnasociety.org

We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open!
www2.rnasociety.org

This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.