Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – Swee Lay Thein

Dr. Swee Lay Thein of NHLBI shared the 2026 Breakthrough Prize for her work on sickle-cell disease and beta-thalassemia.

breakthroughprize.org/Laureates/2/...

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

Beautiful. What type of microscopy is this?

We are hiring POSTDOC now!🚨please repost! Fully-funded 5-year position 👩🏻‍🔬👨‍🔬🧬Looking forward to your application!✉️

Is this a neuron? Dense core granules?

Very cool

West Virginia

Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...

The most sensitive green and red #norepinephrine #sensors engineered to date are out in #naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @erc.europa.eu @snsf.ch doi.org/10.1038/s415...

Microscopy image of keratin (cyan) and desmosomes (magenta)

There are an extremely limited number of open slots for the Analytical and Quantitative Light Microscopy @aqlm.bsky.social course at @mblscience.bsky.social April 29-May 8 2026.

www.mbl.edu/education/ad...
Apply here for this amazing opportunity!

Breaking Fundamental Biological Law: Research by Takashi Akera Investigates Selfish DNA - Vilcek Foundation Winner of the Vilcek Prize for Creative Promise, Akera’s novel research findings have huge implications for infertility and chromosomal disorders.

vilcek.org/news/breakin...

Figure showing the comparison between spinning disk (SD) confocal, SIM and ExM when imaging Drosophila cemtrioles.

Emma Burns, Anastasia Amoiroglou, Gregory Rogers, Nasser Rusan and colleagues develop an expansion microscopy protocol for Drosophila cultured cells and tissues, which they use to dissect centriole biology.
journals.biologists.com/jcs/article/...

Prime numbers 2-4999, animated with ggplot2+gganimate.

#Rstats code: gist.github.com/stephenturne...

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Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028

🚨 Job Alert! 🚨

We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇

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#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social

DC, Winter 2025

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells - PubMed Conformational changes in endocytic proteins are regulators of clathrin-mediated endocytosis. Three clathrin heavy chains associated with clathrin light chains (CLC) assemble into triskelia that link into a geometric lattice that curves to drive endocytosis. Structural changes in CLC have been shown …

We have a number of fluorescent protein pairs here that are great for FLIM www.addgene.org/browse/artic...

Yes! Many of our plasmids are here www.addgene.org/Justin_Taras... and both NPY-GFP (exocytic vesicles) and clathrin light chain-GFP (endocytic sites) make excellent sub-diffraction biological targets.

MBL Announces Largest Ever Gift for Its Renowned Biological Education and Research Programs | Marine Biological Laboratory Cell Biology Researcher Mark Terasaki’s $25 Million Unrestricted Gift Will Support Operations and Infrastructure Contact: Samantha Cummis scummis@mbl.edu; 973.800.4119

We're thrilled to announce the largest private gift in our 137-year history: a $25 million unrestricted donation from MBL Whitman Scientist Mark Terasaki.

His extraordinary generosity will bolster our renowned research and education programs. 🔬

Learn more: bit.ly/452WL1m

Hoya bloom

Woods Hole, MA

Salt Lake from the air

Metro

Japanese Garden, Powell’s Bookstore downtown, Forest Park, SE Division or SE Hawthorne St, Coava coffee, OHSU gondola.

I am excited to share our first Pt replica EM images. It took us a little while, but now we have establish the unroofing, drying and Pt coating workflow 🎉 Great work by our postdoc Luis Wong Dilworth! The image below shows the cytosolic membrane leaflet of a fibroblast 👇

Super cool. Septin/actin rings maybe.

This is a scientific figure from the paper mentioned in the post. It shows fluorescence and electron microscopy images and associated schematics for using the ferritag to image clathrin coated pit proteins.

I'd like to draw your attention to this truly excellent paper from the Taraska lab on cryoET of plasma membrane associated proteins. Everyone who is thinking about probes in the cryoET space should also see what they could do with ferritag (fig 6) www.nature.com/articles/s41...