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Posts by Filipa Simões

Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

1 day ago 1504 426 16 42

I almost forgot: a big thank you to Development's @dev-journal.bsky.social editorial and production teams for being supportive, flexible and responsive re: editorial communication and deadlines, during a period when I faced a serious health problem. It means a lot to have this support.

1 day ago 20 3 0 0
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These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9

2 days ago 183 53 4 5
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Excited to share a new review by @kocherlab.bsky.social and me:

Nature-inspired neuroscience

We discuss diverse sensory systems and behaviors across the animal kingdom and argue for their integration into neuroscience. New tools in diverse systems are making this possible ✨

tinyurl.com/y5y9du27

2 days ago 193 70 1 8
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Crick Crash Course: Embryo development

I am giving a "Crash Course in Embryo Development" for the general public (no science background needed! pitched around GCSE-level) in London on 21st May www.crick.ac.uk/whats-on/cri... We'll dip into development, with a splash of embryo models, and a pinch of ethics. And it's free! Book online 👍

1 day ago 69 25 0 1
Redirecting

🎉 Excited to share that the Danioheart Atlas has now been published! 🎉
We’ve mapped zebrafish heart development across ten developmental stages.

Huge thanks to my incredible collaborators and @stainierlab.bsky.social for making this possible!

📖 Read the full paper here: doi.org/10.1016/j.ce...

1 day ago 9 1 0 1
I’ve had the same editor since 1967. Many times he has said to me over the years or asked me, Why would you use a semicolon instead of a colon? And many times over the years I have said to him things like: I will never speak to you again. Forever. Goodbye. That is it. Thank you very much. And I leave. Then I read the piece and I think of his suggestions. I send him a telegram that says, OK, so you’re right. So what? Don’t ever mention this to me again. If you do, I will never speak to you again

I’ve had the same editor since 1967. Many times he has said to me over the years or asked me, Why would you use a semicolon instead of a colon? And many times over the years I have said to him things like: I will never speak to you again. Forever. Goodbye. That is it. Thank you very much. And I leave. Then I read the piece and I think of his suggestions. I send him a telegram that says, OK, so you’re right. So what? Don’t ever mention this to me again. If you do, I will never speak to you again

Maya Angelou on the joys of being edited

2 days ago 6804 1357 27 80
Science | AAAS

Today we mourn the passing of our beloved central dogma. It served Crick well. But it is time to let go. www.science.org/doi/10.1126/...

4 days ago 66 18 0 4
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Fig. 1. Early expression of TgBAC(ankrd1a:EGFP) transgene in the border zone CMs. Hearts of TgBAC(ankrd1a:EGFP);Tg(−0.8myl7:nls-DsRedExpress) (n = 4) were cryoinjured and left to recover for 6 and 15 h. White dashed line outlines the ventricle. Scale bars, 200 μm.

Fig. 1. Early expression of TgBAC(ankrd1a:EGFP) transgene in the border zone CMs. Hearts of TgBAC(ankrd1a:EGFP);Tg(−0.8myl7:nls-DsRedExpress) (n = 4) were cryoinjured and left to recover for 6 and 15 h. White dashed line outlines the ventricle. Scale bars, 200 μm.

Fig. 6. Persistent TgBAC(ankrd1a:EGFP) expression in CMs adjacent to the residual scar. Hearts (n = 4) of TgBAC(ankrd1a:EGFP);Tg(−0.8myl7:nls-DsRedExpress) zebrafish were cryoinjured and analyzed at 30 dpci, showing different levels of scar resolution (least (A) to most (D) regenerated). The whole hearts after dissection were imaged by fluorescence microscopy (A-D). Serial sections were used for AFOG staining (bright-field images on panels А'-D′) and fluorescence imaging by confocal microscopy (А"-D″). In the indicated region of injury on panels A'-D′, collagen is stained blue, fibrin is stained orange, and CMs are stained brown. Scale bar, 100 μm.

Fig. 6. Persistent TgBAC(ankrd1a:EGFP) expression in CMs adjacent to the residual scar. Hearts (n = 4) of TgBAC(ankrd1a:EGFP);Tg(−0.8myl7:nls-DsRedExpress) zebrafish were cryoinjured and analyzed at 30 dpci, showing different levels of scar resolution (least (A) to most (D) regenerated). The whole hearts after dissection were imaged by fluorescence microscopy (A-D). Serial sections were used for AFOG staining (bright-field images on panels А'-D′) and fluorescence imaging by confocal microscopy (А"-D″). In the indicated region of injury on panels A'-D′, collagen is stained blue, fibrin is stained orange, and CMs are stained brown. Scale bar, 100 μm.

An interesting paper from the Kojic lab shows that ankrd1a - a stress responsive gene is consistently unregulated near damaged site in the ❤️ in zebrafish. Loss of ankrd1a leads to an increase in dedifferentiating cells. Check it out here:
doi.org/10.1016/j.cd...

4 days ago 13 9 1 1
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🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social
📅 1 May–15 June 2026
📩 search2026@igmm.cnrs.fr
📎Full information 👇
#LifeScience #MolecularBiology #Research #PI #CNRS

4 days ago 24 28 1 0

Reminder! Application deadline Friday 8th May

5 days ago 5 4 0 0
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Immune modulation promotes heart regeneration through macrophage and Granulin functions in medaka | PNAS Myocardial infarction results in irreversible cardiomyocyte loss and fibrotic remodeling in adult mammals, whereas some vertebrates retain the abil...

🚨 Turning on heart regeneration through immune modulation?
Led by @kcinc.bsky.social, we show that activating pro-regenerative macrophages induces Granulin, a key driver of cardiomyocyte proliferation and scar resolution in medaka, now published in @pnas.org 💔➡️❤️
www.pnas.org/doi/10.1073/...

6 days ago 19 4 4 1

Many congratulations Ben et al! #TeamMacs 😁

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Proud to share this work with @kevinchalut.bsky.social and Byron Mui. Why do some injuries scar while others regenerate? Using digit tip models, we show the ECM is a key driver. HA-rich ECM promotes regeneration, and boosting it can shift healing away from fibrosis. www.science.org/doi/10.1126/...

1 week ago 30 15 3 4

This is probably the most exciting Science issue as the regeneration field is concerned - massive congratulations Mekayla and team! Super to see it published ❤️‍🔥

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Such cool work, Can - great to see it published! Massive congratulations to the team, hope you are spending a solid week celebrating 😁🎉🍾

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Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo

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Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration Tissue regeneration is rare in mammals, but the digit tip can regrow after amputation, whereas injuries beyond the nail do not. How the microenvironment drives divergent outcomes remains unclear. In this study, we found that the extracellular matrix (ECM)...

With the scientific input and experimental brilliance of the @franzelab.bsky.social this work was made possible. www.science.org/doi/10.1126/...

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Wooohooo!! Amazing to see it out, Mekayla - massive congratulations to you and all the team!!

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So cool, Pedro! Many congratulations to you and all the team 🥳🥳

2 weeks ago 1 0 0 0
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IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We repor...

Very happy to share this study from our group and colleagues now out in Science!
We found that in zebrafish, before the immune system is mature, gut epithelial cells perform immune functions by producing the cytokine IL-22 to shape the microbiota to promote early life gut function
#Zebrafish #Gut

2 weeks ago 55 20 2 3

Super new tool just dropped!! Congratulations to the all team 👏🎊🥳

2 weeks ago 2 0 0 0
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New tool from the lab...check out Novabrowse: An interactive and customizable tool for interpreting BLAST results in genomic context!
www.biorxiv.org/content/10.6...

Does your favorite gene seems to be missing from your species of interest?

Are you sure?

🧵👇 1/n

2 weeks ago 19 8 4 2

"men continued to publish the same number of papers after becoming fathers, women experienced a significant drop in research output (mothers had 31% fewer publications than did fathers 8 years after the birth of their first child)"

3 weeks ago 110 79 3 5

On my CV and biosketch, I list motherhood (2000, 2002, 2004 - present). Then I wanted my reviewers/critics to know.

Now I want ECR women to know. Ask for help. Find your support network.

It is critical that us senior women in science support and advocate for ECR #womeninSTEM.

PAY IT FORWARD

3 weeks ago 62 17 1 1

Amazing news, Giulia!! Such a deserved award, massive congratulations to you and @bsdb.bsky.social!!

3 weeks ago 1 0 0 0

Incredibly deserved- many congratulations, James!

3 weeks ago 2 0 0 0
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@vizgen.bsky.social #MERFISH

4 weeks ago 4 1 0 0

Thank you, Arica! Hope to catch up soon!!

4 weeks ago 0 0 0 0

Fire Elmo seal of approval, oh man!! 😻

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