Why Is MS a More Frequent Complication of EBV Infection in Females? Multiple sclerosis (MS) is a T helper (Th) cell-mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the ...

Why Is MS a More Frequent Complication of EBV Infection in Females?

onlinelibrary.wiley.com/doi/10.1111/...

This is so, so well-articulated.

Preprint: B-cell depletion therapy in multiple sclerosis reduced EBV viral load and was coupled to a pronounced reduction in CD8+ T cell responses to all lytic EBV antigens
www.researchsquare.com/article/rs-9...

Memory T cell aging and rejuvenation Aging profoundly alters memory T cell immunity, reshaping diversity, differentiation, and function. Adamo et al. review how intrinsic aging programs, antigenic experience, and tissue context shape T cell responses and discuss emerging strategies to recalibrate memory T cell immunity in later life without compromising immune balance.

Online now: Memory T cell aging and rejuvenation

A one minute primer on how #AutoSpectral improves spectral flow cytometry unmixing by using per-cell calculation of autofluroscence spectra.

Use our R package and get higher quality spectral data, easy as that!

www.biorxiv.org/content/10.1...

Unique and interactive effects of race/ethnicity, genetics, herpesviruses, age, and gender on immunophenotypes @cp-cellrepmed.bsky.social @fredhutch.org @pgtimmune.bsky.social
www.cell.com/cell-reports...

Review @natrevimmunol.nature.com
Renaissance of antiviral CD8+ T cell immunity in vaccination and disease
www.nature.com/articles/s41...

This is one of the most interesting developments as it appears that authors are now submitting preprints earlier in the process.

A reminder that our data suggests that the best time to post is approx 1 month prior to journal submission (which ~30% now are).

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory @natimmunol.nature.com
www.nature.com/articles/s41...

What is the question? - Genome Biology Genome Biology -

A great read! link.springer.com/article/10.1...

Whenever I feel bad about being responsible for wasting money on failed wet lab experiments I think about the collective failure from Novo Nordisk to pay 250 Canadian dollars to protect a key patent. I hope there's more to the story than that, honestly.

Novo Nordisk's Canadian Mistake

💀wtf!?
""
.. the last time they paid the annual maintenance fee on it was 2018! You can even find a letter where their lawyers send a refund request for the 2017 maintenance fee ($250) because Novo apparently wanted some more time to see if they wanted to pay it...
""
www.science.org/content/blog...

It's a good question whether there is HLA dependence or not for this effect in the live vaccine. But if a similar effect exists for the recombinant vaccine using glycoprotein E only, doesn't that decrease the likelihood of seeing HLA dependence? Or maybe I'm too pessimistic 😅

.@slavov-n.bsky.social on cell size vs cell count in the human body.
Lots of white blood cells in number, lots of adipocytes (fat) in volume.

Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease Single-cell transcriptomics resolves mononuclear phagocyte diversity in the human intestine in health and inflammatory bowel disease.

Single-cell transcriptomics resolves mononuclear phagocyte diversity in the human intestine in health and inflammatory bowel disease @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Our fresh and still-steaming Journal of Clinical Investigation preprint is out! 🚀
We explore how T-cell acute lymphoblastic leukemia (T-ALL) exploits inflammatory CXCR3–CXCL10 signaling within the meninges to drive CNS infiltration.

www.jci.org/articles/vie...

I agree!

Oh, I absolutely share your opinion. It sometimes feels as though people know the answer before asking the question. Though it's constructed as multiple rounds of cost/risk analysis yielding the sentiment that "hey, if we find nothing, it's a resource to others".

😅 but I admit that I'm probably super biased here from studying for the PhD at an engineering department, where I was the applicationist (is that a word?). I'm traumatized by the responsibility of proving the applicability of a method haha.

Idk, maybe there's a young doctor that will use a method created by a physicist and go on to win the Nobel prize! This was the case for Jens Skou, if I get his speech. www.nobelprize.org/uploads/2018...

I don't see biologists or computational folks generating an abundance of tools as a bad thing.

But it could also be collective delusion for all I know 🙈

If every single field in academia is fundamentally a pyramid scheme with the most renowned individuals at the top. Proposing a method seems more likely to generate a new field, in my opinion, compared to proposing an interesting application using a method others are already experts on.

A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes - Nature Immunology The authors identify a Cys→Ser transformation (C19S) in insulin leading to neoepitope presentation and CD4⁺ T cell autoreactivity in type 1 diabetes. Inflammation and oxidative stress enhanced C19S tr...

A very interesting read. I wonder how one could replicate this in other autoimmune disorders. www.nature.com/articles/s41...

Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils Human T cell responses are often studied using blood, yet most T cells reside in tissues. By comparing T cell receptor repertoires from millions of T cells from autologous tonsils and blood, Sureshcha...

We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...

Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.

Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...

Super interesting how conflated the ABC and DN nomenclatures are in B cell biology. Wouldn't it make sense to pick a different acronym for age-associated B cells, and atypical B cells? And "atypical" seems risky to use as models in immunology can become outdated as paradigms shift, no?

A roadmap for defining “extrafollicular” B cell responses The term “extrafollicular” is now being used expansively to describe a variety of B cell processes beyond the original use of the term, potentially obscuring important distinct immunological processes...

Sunday reading. I aspire to write something like this for T cells one day. www.cell.com/immunity/ful...

Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social

Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?

Me as a PhD student:"I hate how useful this is".
Me as a Postdoc: "I LOVE HOW USEFUL THIS IS".