Tumor-specific lncRNA IGF1R-AS1 trans-regulates chromatin interactions associated with oncogenic MYC signaling - Nature Communications The role of long non-coding RNAs (lncRNAs) in regulating cancer progression remains to be explored. Here, the authors identify an antisense lncRNA in the IGF1R locus (IGF1RAS1) which strongly interact...

Excited to share our latest work @natcomms.nature.com !
We uncover how tumor-specific lncRNA IGF1R-AS1 trans-regulates chromatin interactions to drive oncogenic MYC signaling.
A new layer of MYC regulation in prostate cancer. @pcf-science.bsky.social
www.nature.com/articles/s41...

Genomic language model mitigates chimera artifacts in nanopore direct RNA sequencing - Nature Communications Direct RNA sequencing suffers from chimera artifact contamination. Here, the authors develop DeepChopper, a genomic language model that detects artifacts with high accuracy, enabling more reliable tra...

Thrilled to share our new @natcomms.nature.com paper! We introduce a genomic language model that detects and corrects a key chimera artifact in Nanopore direct RNA sequencing—improving isoform and chimeric transcript discovery.
🔗 www.nature.com/articles/s41... @luriecancer.bsky.social #LLM #AI

Androgen receptor–regulated lncRNA PRCAT71 promotes AR signaling through the interaction with KHSRP in prostate cancer Long noncoding RNA PRCAT71 and RNA binding protein KHSRP stabilize androgen receptor mRNA to promote prostate cancer progression.

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@ScienceAdvances
Androgen receptor–regulated lncRNA PRCAT71 promotes AR signaling through the interaction with KHSRP in prostate cancer | Science Advances www.science.org/doi/10.1126/... @pcf-science.bsky.social #lncRNA #ARsignaling #CancerResearch