Excited to be part of this collaboration, thanks to all! Our theory of malaria parasite gliding also helps explain diatom motility. A neat twist: the systems are inverted—malaria uses fixed myosins moving short actin filaments, while diatoms use mobile myosins walking on a long actin bundle.
Diatom gliding motility is so amazing 🚀 Happy to be together with @lettermann.bsky.social part of this great collaboration 😀 Check out the website of this open access publication to learn how their movement can be fast and flexible at the same time. And to watch many more beautiful movies 😉
Just back from the annual meeting of the @dfg.de priority program #SPP2332 on "Physics of Parasitism", this time at the Robert Koch Institute at Berlin. So many great talks and discussions! Already looking forward to next year's meeting at Hamburg👍
Chirality shapes life & infection! 😍
Beautiful work by @freddyfrischknecht.bsky.social & @ulrichschwarz.bsky.social labs! Congrats 🍾🍾🍾
rdcu.be/e0rGu
(2/2) Many thanks to Georgios Pavlou and Isabelle Tardieux for providing such an insightful perspective on our work:
www.nature.com/articles/s41...
(1/2) Our work with @freddyfrischknecht.bsky.social on the chirality of malaria parasites has found its home in the January issue of @natphys.nature.com:
www.nature.com/articles/s41...
Moreover, we are very happy that it comes with a news and views article 👍❤️😀
Now out in @biophysj.bsky.social: our work on the rosettes that sometimes are formed by red blood cells infected by malaria parasites (iRBCs). Surprisingly, they do not marginate, as do white blood cells or "normal" iRBCs, and we explain why (because they are dynamic and effectively soft).
Join us (again) for another fantastic BioMalPar meeting @embl.org and also a great pre-meeting @ciid-heidelberg.bsky.social
I’m really enjoying working with parasitologists Mirko Singer and @freddyfrischknecht.bsky.social on this fascinating system! For a summary on the new story about the origin of chirality in malaria sporozoites, see also @ulrichschwarz.bsky.social ’s thread: bsky.app/profile/ulri...
Two videos on how malaria parasites move: helical motion can be "straighter than a straight line" in active particle models @physrevlett.bsky.social, and sporozoite generate chirality differently from Toxoplasma/ookinetes @natphys.nature.com.
DOIs:
doi.org/10.1103/4kxb...
doi.org/10.1038/s415...
Schematic of limb regeneration in axolotl, with growth controlled by two oppositely oriented morphogen gradients (SHH, FGF8).
Axolotl can regrow lost limbs, matching their body size. How? Our new theory-experiment paper in @pnas.org proposes how oppositely oriented morphogen gradients scaling with animal size promote proportional growth. Great collaboration with @tatianasg.bsky.social @cmcb-tud.bsky.social
Super happy to see this major part of my PhD work out in @natphys.nature.com! Three years of fantastic teamwork with Mirko Singer and @freddyfrischknecht.bsky.social and many others.
Paper: doi.org/10.1038/s415...
More on helical trajectories in @physrevlett.bsky.social:
doi.org/10.1103/4kxb...
Great session with flash talks at #25EngLife. Here @lettermann.bsky.social presenting his work on malaria parasite motility.
📣 Now out in @physreve.bsky.social as editors' suggestion: our theory on the role of different myosin II isoforms during cell migration. For standard parameters, A and B segregate to the front and the back, respectively. Yet for other parameter values, also oscillations are possible.
Now out in ACS Infectious Diseases @pubs.acs.org: joint work from the Lanzer, Tanaka, Schwarz and Cavalcanti-Adam labs within #SFB1129 on the adhesion footprint of malaria-infected infected red blood cells. Read the open access paper here: pubs.acs.org/doi/10.1021/...
Finally published: discovery of an unusual Arp2/3 complex with surprising new function in transmission of #malaria #parasites. Great work by Franzi Hentzschel, Yvonne Sokolowski + David Jewanski + fantastic collaboration with Matthias Marti: www.nature.com/articles/s41...
👉 New paper @physrevlett.bsky.social! Active nematics flow spontaneously, driven by their own constituents, e.g. molecular motors or cells. The transition to spontaneous flows was thought to be always continuous. We now discovered that it can also be discontinuous!
journals.aps.org/prl/abstract...
It was a real pleasure to explore the past and present of fever(s) together with my colleague Ulrich Schwarz from Biophysics yesterday! Thanks to the organisers from InterdisciPlenary Heidelberg for making this event happen!
📢 Preprint alert 📢
(1/6) Our work on 3D force inference for intestinal organoids is now on bioRxiv:
www.biorxiv.org/content/10.1...
Stunning collaboration between @omdrozdowski.bsky.social and @kimboonekamp.bsky.social from the lab of @michaelboutros.bsky.social and with Ulrike Engel. A short🧵...
Check our new paper: "Pair cross-correlation analysis for assessing protein co-localization." Here we provide a quantitative understanding of the image pair cross-correlation method used to analyze spatial co-localization from super-resolution images.
t.co/oXBkoo4YI3
New paper in @biophysj.bsky.social led by @pintupatra.bsky.social on the analysis of two-color superresolution microscopy data, with an application to malaria-infected red blood cells. Collaboration with Lanzer lab in #SFB1129
Finally: Plasmodium actin filaments visualized in all their glory. Congrats Josie and Vojtech: www.embopress.org/doi/full/10....
Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk
Made with #blender, very handy for shiny visualization of more complex (e.g. 3D) data, here the trajectories of malaria sporozoites moving through a hydrogel! Great experiments by Mirko Singer at @freddyfrischknecht.bsky.social lab, we tracked the sporozoites and rendered the resulting trajectories!
