Last Saturday we had a tasting of the real life "ss-NMR" protocol: "Sherry-Saturday: No More Research".
🍷🍷 Jerez de la Frontera (Spain)

The III Workshop of the MSCA-DN GlyCanDrug
started in Seville at cicCartuja @csic.es on 18.11.2025. Four days of glycoscience and cancer, as well as top soft skill courses for the 10 PhD students of the network.

Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime

www.youtube.com/watch?v=tdNn...

Fast and Reliable NMR-Based Fragment Scoring for Drug Discovery Fragment-Based Drug Discovery (FBDD) is a powerful strategy used in the development of new therapeutics. Molecular fragments are screened against a target protein, where interactions are typically cha...

Really excited about this work! We hope Fast NMR scoring can contribute to drug discovery. Thanks Dusan Uhrin @edinburghchem.bsky.social
and Ridvan Nepravishta @rnepravishta.bsky.social @crhorizons.bsky.social for getting us on board of this collaboration. @csic.es

pubs.acs.org/doi/10.1021/...

Insideful!!

Big congrats to Jona for his successful defence of his PhD Thesis. Thanks to the panel @albasilipo.bsky.social Paco Corzana, Pedro Nieto, Victoria Gómez and Miguel A. Rodríguez Carvajal.
Great NMR cake for the celebration!!!
@csic.es

A heads-up: Friday 5th 11am, first PhD defence in the
@angulo-lab.bsky.social since the lab move to Seville. It'll be at
cicCartuja @csic.es. Jona's presenting his work on some pretty cool new STD NMR approaches for low-affinity biomolecular interactions. Co-supervised with Juan C. Muñoz-García.

#bioGUNE_Talent | 👏 Óscar Millet #CICbioGUNE @brtaeus.bsky.social, appointed Vice President of @group-ampere.bsky.social, Europe’s top #NMR organization, the first Spanish scientist to hold this role

🎉 Congratulations, Óscar!

🔗 ow.ly/hxi450Wuwiw

Great week of science in Bilbao @ XL Meeting of the Spanish Royal Society of Chemistry @rseq-quimica.bsky.social. I really enjoyed presenting our developments in Epitope-Perturbation-by-Mutation STD NMR spectroscopy in my invited talk. It opened great discussions with fantastic colleagues. @csic.es

On our way to Jaca #NMRschool #ManuelRicoNMR #NMR2025

Starting our mid-term meeting @GlyCanDrug at @i3S_UPorto in Porto. Putting together the glycoscience we're developing in our European Doctoral Network

Registration to our "Structural Glycoscience" Summer School is open !! Come to Grenoble for #glycotime lectures, practicals, visit to @esrf.fr @cermav.bsky.social and IBS. Information and registration at glycoalps.univ-grenoble-alpes.fr/news/summer-...

Our famous "Structural Glycoscience" summer school is back in June 2025 in Grenoble !! with @angulo-lab.bsky.social @elisafadda.bsky.social @glycoexpasy.bsky.social @romain-vives.bsky.social and many others. Attendance is limited to 40 so register quickly !

STD NMR Epitope Perturbation by Mutation Unveils the Mechanism of YM155 as an Arginine-Glycosyltransferases Inhibitor Effective in Treating Enteropathogenic Diseases Enteropathogenic arginine-glycosyltransferases (Arg-GTs) alter higher eukaryotic proteins by attaching a GlcNAc residue to arginine acceptor sites, disrupting essential pathways such as NF-κB signalin...

Our first paper on STD NMR Epitope Perturbation by Mutation:

Unveiling Mechanism of YM155 as an Arginine-Glycosyltransferases Inhibitor Effective in Treating Enteropathogenic Diseases pubs.acs.org/doi/10.1021/...

Great collabor. Ramón Hurtado, Weston Struwe, Valeria Calvaresi, and Philip Hardwidge

Flucose...😅😅

A privilege to have my former boss Thomas Peters visit our research group in Seville @csic.es, as an invited speaker at the III @GlycoNoVi Workshop.

Excellent scientific discussions today!!
III workshop of the "GlycoNoVi" MSCA-DN European Network in Seville. We thank cicCartuja @csic.es for kindly hosting our meeting at the research centre. (#MSCA-DN)

Screening the human miRNA interactome reveals coordinated up-regulation in melanoma, adding bidirectional regulation to miRNA networks Analysis of ST3GAL1/2 and CD98hc regulation by miRNA reveals co–up-regulation, adding a bidirectional twist to miRNA networks.

Proud of @faezehjame.bsky.social and our latest paper on upregulation by #miRNA. miRNA upregulate protein expression of CD98hc, ST3GAL1 and ST3GAL2 in a coordinated manner. Regulation is bidirectional, changing the picture on how these #RNA work. #glycotime
www.science.org/doi/10.1126/... 🧪

Today, we officially welcome Pablo Valverde to the group, working on our @csic.es MOMENTUM project.
Starting gun fired for exciting computational+NMR times to characterise challenging weak protein-ligand interactions.

Two More Great Names Pass

RIP J. Fraser Stoddart and Martin Karplus.

Attention recent PhD's (thesis finished in 2023 or 2024): the ‘Juan de la Cierva’ call is opening. 2 year postdoc contract!
Interested in molecular recognition for development of new drugs (NMR spectroscopy, computation, AI, biophysical techniques)? Contact us!

www.aei.gob.es/convocatoria...

Xmas is coming to the lab...

one of the 3D structures of a tetrantennary, bisected N-glycan represented with sticks and a transparent surface to indicate its molecular volume. SNFG symbols are used to represent each monosacharide

Fancy glycan of the week 🍬: here ⬇️ is THE fanciest tetrantennary+SDa antigen bisected N-glycan I have ever seen! Found in bovine pregnancy-associated glycoproteins (PAGs) during midpregnancy, see doi.org/10.1093/glyc...

This (and its core-fucosylated companion) will be soon on glycoshape.org 😀👍

PhD position to develop synthetic carbohydrate materials

#PhDposition available in my group at the @mpici.bsky.social!
Join us to develop new #carbohydratematerials

#chemistryjobs #researchjobs #glycotime

jobs.mpikg.mpg.de/jobposting/a...

High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy Pseudomonas aeruginosa is a critical priority pathogen and causes life-threatening acute and biofilm-associated chronic infections. The choice of suitable treatment for complicated infections requires...

I am very proud to share a long story on lectins and biofilm imaging just published in JACS Au by Eva and Lisa in cooperation with many colleagues such as @anneimb.bsky.social 😍 #glycotime #chembio #AMR please have a look here: pubs.acs.org/doi/10.1021/...

This was an amazing collaboration with high affinity ligand for Pseudomonas aeruginosa lectins able to target the bacteria in mice !! #glycotime 🍾

Perspective: on the importance of extensive, high-quality and reliable deposition of biomolecular NMR data in the age of artificial intelligence - Journal of Biomolecular NMR Artificial intelligence (AI) models are revolutionising scientific data analysis but are reliant on large training data sets. While artificial training data can be used in the context of NMR processin...

Perspective by Higman et al: deposition of data for titrations, relaxation rates, PREs, etc in a standardized way, e.g. the NEF format could help develop AI models to accurately predict the dynamic behaviour of a protein from the primary sequence alone. #NMRchat

doi.org/10.1007/s108...

🎄 Exciting News for NMR Enthusiasts! 🎄

This December, join us for an NMR Advent Calendar! 🧪📅
New challenge unlocked on our website each day.

🔓 Starts Today - 1st of December
💻 Visit: nmr.chemistry.manchester.ac.uk/advent24
🎁 Test your knowledge, learn, and have fun!

#NMRchat #AdventCalendar

Sunday coffee time dilation... What a beautiful view!! 😍

Postdoctoral Position at the University of Gothenburg (Sweden) – Developing AI tools for Biomolecular NMR and Structural Biology, posted 11/26/2024 listes.services.cnrs.fr/wws/arc/nmr/... #NMRjobs #NMRchat #NMR 🧲